Publications by authors named "Rumiantseva I"

Previous research showed that clinical manifestations of cataract in OXYS rats closely match those of senile cataract in humans, which led to using this rat strain in studies on the pathogenesis of this disease and on efficacy of new therapeutic methods. The aim of the present work was to analyze morphological changes in the lens of OXYS rats at different stages of cataractogenesis by means of light microscopy and to assess mRNA levels of αA- and αB-crystallin genes in the lens. We studied the animals at age 20 days (no clinical signs of cataract), age 3 months (cataract prevalence is 100%), and at age 12 months (when in the majority of OXYS rats, aberrations in the lens correspond to pronounced stages of this disease).

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Aim: Optimization of conditions of quantitative evaluation of Argentine hemorrhagic fever causative agent.

Materials And Methods: Junin virus (XJ P37 strain) was obtained from National collection of viral hemorrhagic fever causative agents of the 1st pathogenicity group of the 33rd Central Research Testing Institute. Junin virus (XJ P37 strain) culture with biological activity of 5.

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The duration of the persistence and dynamics of accumulation of insertion bvg- Bordetella pertussis mutants were studied in lungs of laboratory mice after intranasal and intravenous challenge by virulent bacteria of the causative agent of whooping cough. The capability of the virulent B. pertussis bacteria to long-term persistence in the body of mice was tested.

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Aim: To analyze the specific features of recurrences of acute promyelocytic leukemia (APL) in children after standard therapy with daunorubicin, cytosine arabinoside (Ara-C), all-trans retinoic acid (ATRA) and to develop further programmed treatment policy.

Subjects And Methods: The study included 9 patients with recurrent APL. The recurrences developed significantly more frequently in a very high-risk group (patients with minimal residual disease being preserved after the intensive therapy phase).

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Aim: To evaluate the efficiency of the original ALL-MB-2002 protocol within the multicenter study of treatment of acute lymphoblastic leukemia (ALL) in children.

Subjects And Methods: A total of 1873 primary patients with ALL aged 1 to 18 years, of whom 1544 patients were enrolled in this study, were notified at 36 clinics of Russia and Belarus from April 15, 2002, to January 1, 2008.

Results: With the median observation of 4.

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Aim: A comparative analysis of efficacy and toxicity of two chemotherapy regimens: standard German protocol ALL-BFM 90m and less intensive original test protocol ALL-MB 91 in a multicenter trial of acute lymphoblastic leukemia (ALL) in children.

Material And Methods: In 1995-2002 a total of 834 patients with newly diagnosed ALL aged 0-18 years were admitted to 10 clinics of Russia. Of them, 713 were randomized in two groups: treatment program ALL-BFM 90m (n = 355) and ALL-MB 91 program (n = 358).

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The incidence of malignant tumors of the buccal mucosa and stages of carcinoma were analyzed in 565 primary patients for a period of 10 years. The study showed social and organization problems in the disease diagnosis: refusal of patients from medical consultation, unjustified omitting of examination of the oral cavity aimed at cancer detection during preventive examinations of the population and treatment of odontogenic diseases, erroneous interpretation of pathological changes in the buccal mucosa, unjustified long observation and treatment by non-oncological specialists, incompetence of physicians, etc. Approaches to optimization of diagnosis are outlined: improvement of the efficiency of preventive examinations by non-oncological specialists, specialized upgrading of dentists and increase of their professional responsibility, and early use of morphological methods of examination of pathological processes in the buccal mucosa.

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It was shown that gamma-irradiation of water-ethanol and water-n-propanol solutions of DNA with doses of 10-30 Gy leads to a fall of the specific volume of the macromolecule upon the cooperative transition at a critical concentration of alcohol in solution at which the destroying of water structure by a nonelectrolyte occurs.

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Methylated Digoxin preparation--beta-Methyldigoxin (Lanitop) was used in 50 patients with congestive heart failure of different etiology (tablets of 0.3--0.6 mG per day).

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