Publications by authors named "Rumi Yoshihama"
Article Synopsis
- The study focuses on how certain stem cell-related transcription factors (SOX2, Oct4, KLF4, c-Myc, and brachyury) impact the metastasis and survival of patients with oral squamous cell carcinoma (OSCC).
- Researchers performed immunohistochemistry on biopsy samples from 108 OSCC patients, finding significant associations between the expression levels of SOX2, KLF4, and brachyury with lymph node and distant metastasis.
- The findings suggest that high expression of SOX2 and KLF4 could serve as predictive factors for metastasis, while lower co-expression of these factors correlates with worse survival rates, highlighting their potential as prognostic markers for OSCC.
CD82/KAI1, a member of the tetraspanin superfamily, is a suppressor of metastasis and CD82 inhibits canonical Wnt signaling via downregulation of several Frizzled (FZD) isoforms, resulting in accumulation of β-catenin at the cell membrane. In this study, we investigated the mechanism through which CD82 inhibited FZD expression by examining the effects of microRNAs (miRNAs). The miRanda algorithm predicted 11 miRNAs from FZD sequences.
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