Students' safety culture at tertiary level academic institutes in Bangladesh: A cross-sectional study.

This study aims to investigate the safety culture of tertiary-level students in Bangladesh and identify the factors that influence it. A cross-sectional survey was conducted among 1676 students from 16 universities and medical colleges in Bangladesh to gather data. The survey consisted of a paper-based structured questionnaire with three scales: a 17-item safety beliefs and values scale, a 10-item safety perception and awareness scale, and a 14-item safety attitudes scale.

MetaCompare 2.0: differential ranking of ecological and human health resistome risks.

While numerous environmental factors contribute to the spread of antibiotic resistance genes (ARGs), quantifying their relative contributions remains a fundamental challenge. Similarly, it is important to differentiate acute human health risks from environmental exposure, versus broader ecological risk of ARG evolution and spread across microbial taxa. Recent studies have proposed various methods for achieving such aims.

Chalcophosphate metasurfaces with multipolar resonances and electro-optic tuning.

We computationally analyze the electro-optic response of metasurfaces consisting of interconnected nanoantennas with multipolar resonances using a chalcophosphate, SnPS, as the active material. SnPS has large electro-optic coefficients and relatively low Curie temperature (<70 °C), allowing for strong changes in the refractive index of the material under moderate electric fields if the temperature can be finely controlled in proximity of the Curie point. Through numerical simulations, we show that metasurfaces designed with this nanostructured material demonstrate a significant shift of multipolar resonances upon biasing, despite moderate refractive-index values of the chalcophosphate and reduced mode localization due to this.

Towards women's digital health equity: A qualitative inquiry into attitude and adoption of reproductive mHealth services in Bangladesh.

Health equity in Bangladesh faces a large chasm over the economic conditions, socio-cultural factors and geographic location despite the push for digitalization of the health sector. While some research has been conducted assessing the viability of digital health solutions in Bangladesh, gender dynamics of digital healthcare have been absent. This study dived into healthcare equity for women with a focus on reproductive health services delivered through mobile devices.

Importance of Transcript Variants in Transcriptome Analyses.

RNA sequencing (RNA-Seq) has become a widely adopted technique for studying gene expression. However, conventional RNA-Seq analyses rely on gene expression (GE) values that aggregate all the transcripts produced under a single gene identifier, overlooking the complexity of transcript variants arising from different transcription start sites or alternative splicing. Transcript variants may encode proteins with diverse functional domains, or noncoding RNAs.

ERβ Regulation of Indian Hedgehog Expression in the First Wave of Ovarian Follicles.

Increased activation of ovarian primordial follicles in knockout () rats becomes evident as early as postnatal day 8.5. To identify the ERβ-regulated genes that may control ovarian primordial follicle activation, we analyzed the transcriptome profiles of rat ovaries collected on postnatal days 4.

Loss of ERβ Disrupts Gene Regulation in Primordial and Primary Follicles.

Loss of ERβ increases primordial follicle growth activation (PFGA), leading to premature ovarian follicle reserve depletion. We determined the expression and gene regulatory functions of ERβ in dormant primordial follicles (PdFs) and activated primary follicles (PrFs) using mouse models. PdFs and PrFs were isolated from 3-week-old knockout () mouse ovaries, and their transcriptomes were compared with those of control mice.

Thermoplasmonic Controlled Optical Absorber Based on a Liquid Crystal Metasurface.

Metasurfaces can be realized by organizing subwavelength elements (e.g., plasmonic nanoparticles) on a reflective surface covered with a dielectric layer.

The assessment of geriatric malnutrition, geriatric depression and associated co-morbidities among forcibly displaced Myanmar nationals in Bangladesh.

Objective: To assess the nutritional status and depression of the elderly forcibly displaced Myanmar nationals (FDMN) in Bangladesh and determine the associated factors of geriatric depression (GD).

Design: This was a community-based, cross-sectional study among elderly FDMN. The Mini Nutritional Assessment Short-Form (MNA@-SF) and Geriatric Depression Scale Short-Form (GDS-15 SF) were used to determine malnutrition and GD, respectively.

Approaches for Selective Vaccinations in Cirrhotic Patients.

Bacterial and viral infections are common in cirrhotic patients, and their occurrence is associated with the severity of liver disease. Bacterial infection may increase the probability of death by 3.75 times in patients with decompensated cirrhosis, with ranges of 30% at 1 month and 63% at 1 year after infection.

Hedgehog Signaling in Gonadal Development and Function.

Three distinct hedgehog (HH) molecules, (sonic, desert, and indian), two HH receptors (PTCH1 and PTCH2), a membrane bound activator (SMO), and downstream three transcription factors (GLI1, GLI2, and GLI3) are the major components of the HH signaling. These signaling molecules were initially identified in . Later, it has been found that the HH system is highly conserved across species and essential for organogenesis.

Transcriptional regulation of in mouse trophoblast stem cells.

SATB homeobox proteins are important regulators of developmental gene expression. Among the stem cell lineages that emerge during early embryonic development, trophoblast stem (TS) cells exhibit robust SATB expression. Both SATB1 and SATB2 act to maintain the trophoblast stem-state.

Antimicrobial resistance studies in staphylococci and streptococci isolated from cows with mastitis in Argentina.

Background: and are the main cause of clinical mastitis in dairy cattle in Argentina, whereas coagulase-negative staphylococci (CNS) and environmental streptococci are the main cause of subclinical mastitis. Bacteria isolated from infected animals show increasing antimicrobial resistance.

Objectives: This study aims to determine the antimicrobial resistance of staphylococci and streptococci isolated from milk with mastitis, and to genotypically characterize the methicillin-resistant (MR) staphylococci.

Accuracy of FIB-4 to Detect Elevated Liver Stiffness Measurements in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Referral Centers.

The identification of advanced fibrosis by applying noninvasive tests is still a key component of the diagnostic algorithm of NAFLD. The aim of this study is to assess the concordance between the FIB-4 and liver stiffness measurement (LSM) in patients referred to two liver centers for the ultrasound-based diagnosis of NAFLD. Fibrosis 4 Index for Liver Fibrosis (FIB-4) and LSM were assessed in 1338 patients.

A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations.

Background And Objectives: Genotyping is an important tool for studying gene functions in animals or detecting genetic variants in humans. Various methods using low to high concentrations of agarose or polyacrylamide gel electrophoresis have been developed for genotyping. These methods rely on the detection of large-size differences (20-2,000 bp) of targeted PCR products between a wild-type gene and a mutant gene.

Dengue Fever Responses in Dhaka City, Bangladesh: A Cross-Sectional Survey.

This study intends to evaluate the Dhaka city residents' individual views toward DF. A cross-sectional survey used google forms for collecting data. Python and RStudio were used for data management and analysis.

The role of Kisspeptin signaling in Oocyte maturation.

Kisspeptins (KPs) secreted from the hypothalamic KP neurons act on KP receptors (KPRs) in gonadotropin (GPN) releasing hormone (GnRH) neurons to produce GnRH. GnRH acts on pituitary gonadotrophs to induce secretion of GPNs, namely follicle stimulating hormone (FSH) and luteinizing hormone (LH), which are essential for ovarian follicle development, oocyte maturation and ovulation. Thus, hypothalamic KPs regulate oocyte maturation indirectly through GPNs.

DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin.

Erythropoietin (EPO) signaling plays a vital role in erythropoiesis by regulating proliferation and lineage-specific differentiation of murine hematopoietic progenitor cells (HPCs). An important downstream response of EPO signaling is calcium (Ca) influx, which is regulated by transient receptor potential channel (TRPC) proteins, particularly TRPC2 and TRPC6. While EPO induces Ca influx through TRPC2, TRPC6 inhibits the function of TRPC2.

Left ventricular strain predicts subclinical atherosclerosis in nonadvanced nonalcoholic fatty liver disease patients.

Objectives: The association between nonalcoholic fatty liver disease (NAFLD) and carotid atherosclerosis is still controversial. The present study was designed to assess the relationship between left ventricular systolic mechanics, noninvasively assessed by two-dimensional (2D) speckle-tracking echocardiography (STE) and common carotid artery (CCA) intima-media thickness (IMT), in patients with nonadvanced NAFLD.

Methods: All consecutive NAFLD patients diagnosed with liver stiffness measurement (LSM) <12.

Knowledge, Attitude, and Practices towards Dengue Fever among University Students of Dhaka City, Bangladesh.

Dhaka has become the worst affected city in Bangladesh regarding dengue fever (DF). A large number of university students are residing in this city with a high DF risk. This cross-sectional study was conducted to assess the DF status and responses among these students through their Knowledge, Attitude, and Practices (KAP) survey.

Sexual Dimorphism in Kisspeptin Signaling.

Kisspeptin (KP) and kisspeptin receptor (KPR) are essential for the onset of puberty, development of gonads, and maintenance of gonadal function in both males and females. Hypothalamic KPs and KPR display a high degree of sexual dimorphism in expression and function. KPs act on KPR in gonadotropin releasing hormone (GnRH) neurons and induce distinct patterns of GnRH secretion in males and females.

DOT1L Mediated Gene Repression in Extensively Self-Renewing Erythroblasts.

DOT1L is essential for embryonic hematopoiesis but the precise mechanisms of its action remain unclear. The only recognized function of DOT1L is histone H3 lysine 79 (H3K79) methylation, which has been implicated in both transcriptional activation and repression. We observed that deletion of the mouse gene (KO) or selective mutation of its methyltransferase domain (MM) can differentially affect early embryonic erythropoiesis.