Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers.

Background: Carbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that is increased in heart failure (HF) and associated with inflammation, fluid overload, and worse adverse events. Our main objective was to study the expression of CA125 on epicardium and its association with inflammation, adipogenesis, and fibrosis.

Methods: Epicardial fat biopsies and blood were obtained from 151 non-selected patients undergoing open heart surgery.

The genomic analysis of endometrial mitochondrial DNA copy number variation on recurrent implantation failure.

Objective: Aim of this study was to define the relationship between RIF (Recurrent Implantation Failure) and endometrial mtDNA copy number.

Study Design: A total of 50 women of reproductive age including twenty-five patients clinically diagnosed with RIF and twenty-five fertile women as healthy controls were recruited into the study. Endometrial biopsy samples were obtained with a pipelle at the 20-24 days of the menstrual cycle of each participant.