Favorable effects of glibenclamide in a patient exhibiting idiosyncratic hepatotoxic reactions to both chlorpropamide and tolbutamide.

A middle-aged diabetic woman after four weeks of chlorpropamide treatment developed cholestatic hepatitis with systemic manifestations of idiosyncratic reaction. After recovery, unintended rechallenge with the same drug induced a brisk exacerbation of the symptoms and signs that reversed completely following chlorpropamide withdrawal. Tolbutamide medication was subsequently well tolerated for several weeks, followed by another flare of cholestatic liver lesion and cutaneous eruption with eosinophilia (after each reaction the patient was treated with insulin).

Indapamide versus beta-blocker therapy: a double-blind, crossover study in essential hypertension.

A controlled, double-blind, double-placebo, crossover clinical trial was carried out in 24 mild to moderate hypertensives of either sex to compare the anti-hypertensive and other effects of indapamide (2.5 mg) and pindolol (15 mg). After a 2-week run-in placebo period the patients were randomly assigned to one of the drugs in the study for 6 weeks.

Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension.

In a randomized cross-over study the acute effects of intravenous labetalol (1-2 mg/kg; mean dose 86.5 mg) were compared with those of diazoxide (3-5 mg/kg; mean dose 253.8 mg) in 13 severely hypertensive patients with diastolic blood pressure above 110 mm Hg (36.