Publications by authors named "Rulu Fang"
Article Synopsis
- This study evaluates the effectiveness and safety of Qingpeng ointment (QPO), a Tibetan remedy, for treating symptoms of acute gouty arthritis (AGA) in patients experiencing significant joint pain.
- Conducted as a randomized, double-blind, placebo-controlled trial, 203 participants with AGA received either QPO or a placebo for seven days, with joint pain and swelling being the primary outcomes measured.
- The results indicated that the QPO group had reduced joint pain and swelling compared to the placebo group, along with improved joint mobility, while some mild adverse events were reported among participants, mainly skin irritations.
Polygonum cuspidatum (Huzhang, HZ) is one of the commonly used traditional Chinese medicines for treating gouty arthritis (GA), but the specific mechanism is not clear. This study employed network pharmacology and molecular docking techniques to examine the molecular mechanisms underlying the therapeutic effects of HZ on GA. The network pharmacology approach, including active ingredient and target screening, drug-compound-target-disease network construction, protein-protein interaction (PPI) networks, enrichment analysis, and molecular docking, was used to explore the mechanism of HZ against GA.
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