Molecular dynamics of neutral polymer bonding agent (NPBA) as revealed by solid-state NMR spectroscopy.

Neutral polymer bonding agent (NPBA) is one of the most promising polymeric materials, widely used in nitrate ester plasticized polyether (NEPE) propellant as bonding agent. The structure and dynamics of NPBA under different conditions of temperatures and sample processing are comprehensively investigated by solid state NMR (SSNMR). The results indicate that both the main chain and side chain of NPBA are quite rigid below its glass transition temperature (Tg).

The morphology and fabrication of nanostructured micelle by a novel block copolymer with linear-dendritic structure.

We report here a novel approach to fabricate a nanostructured micelle as potential drug carriers and the relationship between the morphological structure and the preparation condition. The polymeric micelle aggregates constructed by self-assembly compose of the poly(ε-caprolactone)/monomethoxy poly(ethylene glycol) linear-dendritic block copolymers. The corresponding copolymers were synthesized by using ring opening polymerization of ε-caprolactone (CL) and a dendritic poly(ether-amide) (DPEA-OH) as an initiator, then coupling with the isocyanate end-capped linear monomethoxy polyethylene glycol.

Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China.

Aim: To explore the mode of inheritance of hepatocellular carcinoma (HCC) in a moderately high-incidence area of East China.

Methods: A pedigree survey was conducted in 210 families (3315 individuals) ascertained through 210 HCC probands in Haimen, Jiangsu Province. Simple segregation analysis was conducted using SEGRANB software.

[A study on the relationship of birth order hepatocellular carcinoma].

Objective: To explore the association of hepatocellular carcinoma (HCC) with environmental factors through analyzing birth order data from pedigree sibships.

Methods: A birth order study was conducted based on the methods of Greenwood and Haldane for 100 probands and 22 affected siblings from 100 pedigrees in a cohort which was followed up for 8 years in Haimen, Jiangsu, China.

Results: The findings from the Greenwood method suggested that there was a tendency for cases of HCC to concentrate at lower birth orders of 1 to 3.

[A study on the genetic epidemiology of hepatocellular carcinoma].

Objective: To explore the interaction between inheritance and environment with the aid of research on the genetic modes of hepatocellular carcinoma (HCC).

Methods: A genetic epidemiological study of HCC was conducted based on the methods of Penrose, simple segregation and Falconer for 100 proband pedigrees from HBsAg positive cohort. The proband samples came from a cohort of 90,00 people who were followed for 8 years.