Publications by authors named "Ruliang Sun"
Objective: This study aimed to explore the specific pathways by which HOX transcript antisense intergenic RNA contributes to the pathogenesis of unexplained recurrent spontaneous abortion.
Methods: Real-time quantitative PCR was employed to assess the differential expression levels of HOX transcript antisense intergenic RNA in chorionic villi tissues from unexplained recurrent spontaneous abortion patients and women with voluntarily terminated pregnancies. HTR-8/SVneo served as a cellular model.
High prevalence of thalassemia with a novel α-thalassemia mutationin in Baoan populations in Guangdong province, China.
Eur J Obstet Gynecol Reprod Biol
December 2020
Meiotic entry and progression require dynamic regulation of germline gene expression. mA on mRNAs and recognition by YTHDC2 has been known as post-transcriptional regulatory complex, but the roles of this regulator remain unclear for meiotic initiation and progression in female germ cells (FGCs). This study showed that mA modification occurred mainly in FGCs rather than ovarian somatic cells (SOMAs), and mA levels in FGCs increased significantly with meiotic initiation.
View Article and Find Full Text PDFArticle Synopsis
- - Meckel syndrome (MKS) is a severe genetic disorder characterized by multiple birth defects, particularly affecting the brain, kidneys, and other organs, and is inherited in an autosomal recessive manner; it involves variants in the CEP290 gene.
- - A case study focused on a 35-year-old pregnant Chinese woman whose fetus exhibited severe malformations, including meningoencephalocele and cystic kidney abnormalities, led to the termination of the pregnancy and subsequent genetic analysis.
- - Genetic testing revealed a novel homozygous variant in the CEP290 gene in the fetus, linked to the loss of function of the protein, distinguishing it as a new MKS4 variant unique to the Chinese population.
Inflammation and immunity are thought as risk factors for uterine leiomyoma; however, detailed reports on this topic are scarce. The present study aimed to analyze the characteristics of immune function and clinical significance of circulating CD4/CD8 T, NK, and T cells in reproductive females with uterine leiomyoma. We analyzed the above-mentioned cells in 30 reproductive females with uterine leiomyoma and 68 healthy females using flow cytometry.
View Article and Find Full Text PDFgene contributes to DNA repair defects and genomic instability, which may lead to the initiation of uterine leiomyoma. We hypothesized that genetic variants of gene may alter the carriers' susceptibility to leiomyoma. The association between five potential functional single nucleotide polymorphisms (SNPs), i.
View Article and Find Full Text PDF