Publications by authors named "Rulan Liu"
LL37-DNA Complex Drives Vitiligo Progression Through TLR9-MyD88 Signaling Pathways.
Pigment Cell Melanoma Res
January 2025
Article Synopsis
- Vitiligo is an autoimmune condition that leads to white patches on the skin due to the destruction of melanocytes by CD8 T cells, influenced by various immune-related factors.
- The study found increased levels of LL37, a molecule linked to autoimmune diseases, in the blood and skin lesions of vitiligo patients.
- LL37 may contribute to melanocyte loss by enhancing certain inflammatory signals and helping CD8 T cells migrate, particularly under conditions of oxidative stress.
Objectives: The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.
Methods: Published papers on vitiligo, oxidative stress and DAMPs were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc.
A CASE REPORT of Lichen Nitidus on the Penis: Tiny but Annoying Eruptions.
Clin Cosmet Investig Dermatol
June 2022
Article Synopsis
- A study focuses on a case of lichen nitidus, a skin condition that causes small skin-colored papules on the penis, affecting a 40-year-old male patient.
- The patient received treatment with tacrolimus cream and humectant, which helped alleviate his symptoms.
- The study aims to improve understanding of lichen nitidus in order to reduce misdiagnosis and avoid unnecessary treatments for patients with similar skin lesions.
Background: Experimental autoimmune encephalomyelitis (EAE) models are important vehicles for studying the effect of infectious elements such as Pertussis toxin (PTx) on disease processes related to acute demyelinating encephalomyelitis (ADEM) or multiple sclerosis (MS). PTx has pleotropic effects on the immune system. This study was designed to investigate the effects of PTx administered intracerebroventricularly (icv) in preventing downstream immune cell infiltration and demyelination of the spinal cord.
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