Respiratory patterns and physical fitness in healthy adults: a cross-sectional study.

Background: The altered respiratory patterns have a significant impact on our health. However, the links between respiration patterns during spontaneous breathing and physical fitness remain unknown. Therefore, we sought to examine how the respiratory pattern during spontaneous breathing interacts with physical fitness.

Respiratory Movements at Different Ages.

The current study aimed to better understand the changes in respiration that occur with aging in men and women to provide accurate recommendations for breathing exercises to improve health. A total of 610 healthy subjects, aged 20 to 59, participated in the study. They performed quiet breathing while wearing two respiration belts (Vernier, Beaverton, OR, USA) at the height of the navel and at the xiphoid process to record abdominal motion (AM) and thoracic motion (TM), respectively.

Remotely Programmable Deep Brain Stimulator Combined with an Invasive Blood Pressure Monitoring System for a Non-Tethered Rat Model in Hypertension Research.

The control circuits of blood pressure have a strong neural regulatory element important in the pathogenesis of essential drug-resistant hypertension. Targeting lower medullary neural control mechanisms of blood pressure by electrical stimulation could be beneficial, and therefore, a novel device is needed. This paper presents a remotely programmable deep brain stimulator with an invasive continuous blood pressure monitoring system in a non-tethered rat model.

Sex differences in serotonergic control of rat social behaviour.

Rationale: There is increasing evidence that enhancement of the salience of social stimuli can have a beneficial effect in managing many psychiatric conditions. There are, however, clear sex-related differences in social behaviour, including the neural mechanisms responsible for different aspects of social functions.

Objectives: We explored the role of the serotonergic system on rat social behaviour under baseline and under stressful conditions in female and male rats.

Women's Respiratory Movements during Spontaneous Breathing and Physical Fitness: A Cross-Sectional, Correlational Study.

Background: Abdominal/diaphragmatic breathing exercises are popular worldwide and have been proven to be beneficial for physical performance. Is abdominal motion (AM) during spontaneous breathing correlated with physical fitness? The present study aimed to answer this question.

Methods: 434 women (aged 20-59) were enrolled and participated in respiration tests using two respiration belts (one was tied at the height of the xiphoid and another at the navel) to detect AM and thoracic motion (TM).

What is there to know about the effects of progestins on the human brain and cognition?

Progestins are an important component of hormonal contraceptives (HCs) and hormone replacement therapies (HRTs). Despite an increasing number of studies elucidating the effects of HCs and HRTs, little is known about the effects of different types of progestins included in these medications on the brain. Animal studies suggest that various progestins interact differently with sex steroid, mineralocorticoid and glucocorticoid receptors and have specific modulatory effects on neurotransmitter systems and on the expression of neuropeptides, suggesting differential impacts on cognition and behavior.

Evaluating suitability of saliva to measure steroid concentrations in grey seal pups.

Measurement of steroids in wild pinnipeds can facilitate assessment of breeding, nutritional and stress status, and is useful in understanding behavioral responses. Even in young animals, sex steroids may be important in behavioral interactions and immune modulation. Use of saliva can avoid the large fluctuations seen in some steroids in plasma, and can negate the need for venipuncture, making it a potentially useful matrix in the wildlife.

Plexiform neurofibroma of the cauda equina with follow-up of 10 years: A case report.

Background: Plexiform neurofibromas are extremely rarely found in the region of cauda equina and can pose a significant challenge in the diagnostic and management sense. To our knowledge, only 7 cases of cauda equina neurofibromatosis (CENF) have been reported up-to-date.

Case Summary: We describe a case of a 55-year-old man with a 10 years history of progressive lower extremities weakness and bladder dysfunction.

Melatonin Reduces Alcohol Drinking in Rats with Disrupted Function of the Serotonergic System.

The reason for the limited treatment success of substance-use-related problems may be a causal heterogeneity of this disorder that, at least partly, is manifested as differences in substance-use motives between individuals. The aim of the present study was to assess if rats with pharmacologically induced differences in the function of the serotonergic system would respond differently to melatonin treatment compared to control rats with respect to voluntary alcohol consumption. To achieve this goal, we treated rats neonatally with the selective serotonin transporter (SERT) inhibitor escitalopram.

The Anticonvulsant Lamotrigine Reduces Bout-Like Alcohol Drinking in Rats.

We used an optical lickometer system to study drinking microstructure and effect of lamotrigine in voluntary alcohol-drinking rats. We showed that, similar to humans, animals differ by their drinking microstructure where some consume alcohol exclusively in a bout-like patterns. The study suggests that anticonvulsants, such as lamotrigine, may be one treatment strategy specifically affecting this type of drinking.

Glutamate and NMDA affect cell excitability and action potential dynamics of single cell of macrophyte Nitellopsis obtusa.

The effect of glutamate and N-methyl-d-aspartate (NMDA) on electrical signalling - action potentials (AP) and excitation current transients - was studied in intact macrophyte Nitellopsis obtusa (Characeaen) internodal cell. Intracellular glass electrode recordings of single cell in current clamp and two-electrode voltage clamp modes indicate that glutamate (Glu, 0.1-1.

Modulation of responses to visual stimulus onset and offset by chronic alcohol consumption and withdrawal in the rat visual cortex and lateral geniculate nucleus.

In the visual system, chronic alcohol consumption and subsequent abstinence strongly modulate processing of sensory information, which could interfere with the actions in our daily lives. Although previous studies showed histological and electrophysiological changes in the retina and visual cortex during chronic alcohol consumption and abstinence, there is still a lack of information related to the effect of alcohol on: 1) different stages of visual information processing; and 2) responses of stimulus onset (ON) and offset (OFF). In order to answer these questions, we recorded visual evoked potentials (VEPs), elicited by onset and offset of a 500-ms stimulus, following long-term alcohol consumption (8 weeks) and abstinence (3 weeks) in freely moving Wistar rats.

Mental rotation of sequentially presented 3D figures: sex and sex hormones related differences in behavioural and ERP measures.

Mental rotation of 3D objects demonstrates one of the largest sex differences. We investigated sex and sex hormones-related differences in behaviour and event related potentials (ERP) using a modified Shepard and Metzler task composed of sequentially presented 3D figures in 29 men and 32 women. We demonstrated a significant increase in response time and decrease in both accuracy and positivity of the parietal ERP with increasing angular disparity between the figures.

Do oral contraceptives modulate an ERP response to affective pictures?

Indications exist that use of oral contraceptives affects women's socio-emotional behaviour, brain function and, cognitive abilities, but the information is still scarce and ambiguous. We aimed to examine affective processing of visual stimuli between oral contraceptive users (OC, n = 33) and naturally cycling women (NC, n = 37) using the event-related potential (ERP) method. The main findings are: (i) emotionally arousing stimuli elicited significantly enlarged late positive potential (LPP) amplitudes compared to neutral stimuli, (ii) anti-androgenic OC users demonstrated diminished brain reactivity to visual stimuli, and (iii) significantly blunted reaction to highly unpleasant images.

DNA-Damaging Effect of Different Wavelength (206 and 257 nm) Femtosecond Laser Pulses.

The purpose of this study was to investigate the possible cytotoxic and genotoxic impact of new-generation 206 nm femtosecond solid-state laser irradiation on murine skin cells in vitro, and to compare the cell and DNA damage caused by different wavelength (206 vs. 257 nm) femtosecond laser pulses. The first attempts to evaluate the possible genotoxic impact of ultrashort laser pulses on the murine bone marrow cells in vitro revealed the unlooked-for DNA-damaging effect.

Hemodynamic effects of sex and handedness on the Wisconsin Card Sorting Test: the contradiction between neuroimaging and behavioural results.

This study investigated the potential role of sex and handedness on the performance of a computerised Wisconsin Card Sorting Test (WCST) in healthy participants by applying functional near-infrared spectroscopy (fNIRS). We demonstrated significant ( < 0.05) sex-related differences of hemodynamic response in the prefrontal cortex of 70 healthy participants (female, = 35 and male, = 35; right-handed, = 40 and left-handed, = 30).

Asparagine alters action potential parameters in single plant cell.

Effect of amino acid L-asparagine on electrical signalling of single Nitellopsis obtusa (Characeaen) cell was investigated using glass-microelectrode technique in current-clamp and voltage-clamp modes. Cell exposure for 30 min to 0.1 mM and 1 mM of asparagine resulted in changes of electrically stimulated action potential (AP) parameters in comparison to standard conditions.

Does the use of hormonal contraceptives affect the mental rotation performance?

Oral contraceptive pill (OC) is one of the most popular form of contraception. Despite both behavioral and neuroimaging evidence of its significant impact on female brain and cognitive functions, much remains to be discovered regarding OCs targets in the brain and mechanisms of action. In the present study mental rotation performance was compared between women using anti-androgenic oral contraceptives (n = 35), naturally cycling (NC) women (n = 33) and men (n = 29).

Effect of ethanol on the visual-evoked potential in rat: dynamics of ON and OFF responses.

The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administration of ethanol.

Sex differences in equiprobable auditory Go/NoGo task: effects on N2 and P3.

The Go/NoGo variants of the auditory event-related potentials were shown promising for clinical researches; however, prior to the wider application, it is important to evaluate potential modulating factors. We aimed to evaluate gender effect on the behavioral and electrophysiological responses in an auditory equiprobable Go/NoGo task. The auditory equal probability Go/NoGo paradigm with two types of stimuli was presented to 79 healthy subjects (40 females and 39 males, age 18-30 years) during EEG recording.

Association Between Resting-State Microstates and Ratings on the Amsterdam Resting-State Questionnaire.

There is a gap in understanding on how physiologically observed activity is related to the subjective, internally oriented experience during resting state. Microstate analysis is a frequent approach to evaluate resting-state EEG. But the relationship of commonly observed resting-state microstates to psychological domains of resting is not clear.

Effect of attention on 40Hz auditory steady-state response depends on the stimulation type: Flutter amplitude modulated tones versus clicks.

Auditory steady-state responses (ASSRs) are used to test the ability of local cortical networks to generate gamma frequency activity in patients with psychiatric disorders. For the effective use of ASSRs in research and clinical applications, it is necessary to find a comfortable stimulation type and to know how ASSRs are modulated by the tasks given to the subjects during the recording session. We aimed to evaluate the suitability of flutter amplitude modulated tone (FAM) stimulation for generation of ASSRs: subjective pleasantness of FAMs and attentional effects on FAM-elicited 40Hz ASSRs were assessed.

Go and NoGo: modulation of electrophysiological correlates by female sex steroid hormones.

Rationale: The behavioral and electrophysiological responses in a Go/NoGo task are objective measures of executive functioning that may be impaired in clinical conditions. Prior to the wider application of Go/NoGo tasks in clinics, it is tempting to evaluate factors causing modulation of the responses.

Objective: We aimed to evaluate the effect of different levels of female sex steroids on Go/NoGo task-related ERPs in healthy females.