Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes.

A series of eight bis(thiosemicarbazone) ligands and 16 of their respective copper(II) and zinc(II) complexes containing a combination of hydrogen, methyl, pyridyl, phenyl, and/or ethyl substituents at the diimine position of the ligand backbone were synthesized and characterized. The objective of this study was to identify the structure-activity relationships within a series of analogues with different substituents at the diimine position of the backbone and at the terminal N atom. The Cu(II) complexes Cu(GTSM), Cu(GTSCM), Cu(PyTSM), Cu(EMTSM) and Cu(PGTSM) demonstrated a distorted square planar geometry, while the Zn(II) complexes Zn(ATSM)(DMSO), Zn(PyTSM)(DMSO), and Zn(PGTSM)(HO) formed a distorted square pyramidal geometry.

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.

Over 44 million people live with Alzheimer's disease (AD) worldwide. Currently, only symptomatic treatments are available for AD and no cure exists. Considering the lack of effective treatments for AD due to its multi-factorial pathology, development of novel multi-target-directed drugs are desirable.

N,N'-[1,3-Phenyl-enebis(methyl-ene)]di-p-toluenesulfonamide.

In the title compound, C(22)H(24)N(2)O(4)S(2), the dihedral angles between the central benzene ring and the pendant rings are 66.96 (13) and 69.37 (13)°.