[Analysis of age-related incidence (by circulation) of age-associated pathology in 2018-2023 on the example of the municipal polyclinic of Saint-Petersburg.].

From the age of 25-30, the likelihood of developing pathological processes associated with aging begins to increase. Age-associated diseases (AAD) are a heterogeneous group of pathologies that are more likely to develop as they age. Clinically, the early development of AAD is identical to premature aging with all the ensuing consequences.

[Accelerated population aging as a consequence of the COVID-19 pandemic (review).].

The COVID-19 pandemic has had an impact on many aspects of human life. One of the consequences of the coronavirus period was the accelerated aging of the population. This fact is confirmed in the works of many scientists.

[Prognostic potential of inflammatory factors in older patients diagnosed with COVID-19.].

The COVID-19 pandemic requires a quick and accurate diagnosis and assessment of the condition of patients, correctly chosen by the tactics of treatment and prediction of the course of the disease, especially in older patients. The most promising direction is the study of the potential of inflammatory factors among people over 60 years of age. This paper analyzed serum level characteristics of analytes such as C-reactive protein, procalcitonin, IL-6, troponin, ferritin and brain natriuretic peptide.

[The influence of pseudoexfoliation syndrome on central retina in elderly patients.].

to evaluate the effect of pseudoexfoliation syndrome (PXF) on the stage of age-related macular degeneration (AMD) and central retinal thickness, measured by optical coherence tomography (OCT) in elderly patients living in Saint-Petersburg. 25 elderly patients (30 eyes) with PXF and 25 age-matched patients (29 eyes) without PXF (control group) were included in the study. Retinal thickness in fovea and parafovea as well as AMD stage were compared in the groups.

[Age-related changes in hematological parameters in patients with acute coronary syndrome.].

Over the past decade, there has been a great interest in hematological indicators as markers for assessing the severity of coronary artery disease and stratifying the risk of cardiovascular events in patients with acute coronary syndrome. To understand the possibility of using hematological indicators as predictors of adverse outcomes in this category of patients, the question of clarifying their age-related changes became a question. This study discusses age-related changes in hematological parameters in patients with acute coronary syndrome.

[Features of the coefficient of variation of hematological indicators in persons of middle, elderly and senile age with pneumonia.].

Pneumonia is the leading mortality rate among all infectious diseases. It has been established that the reliable risk group for morbidity and mortality from this nosology includes persons over 60 years of age, and with age the severity of the disease only increases. According to literary data, one of the reasons for the decline in adaptation capabilities of older persons is the phenomenon of «age desinhronosis», which manifests itself in significant fluctuations in the parameters of the internal environment of the body.

Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19.

The paper presents the results of a standard and complex treatment method using the peptide drug thymus thymalin in patients with COVID-19. One of the mechanisms of the immunomodulatory effect of thymalin is considered to be the ability of this peptide drug to influence the differentiation of human hematopoietic stem cells (HSCs). It was found that, as a result of standard treatment, patients in the control group showed a decrease in the concentration of the pro-inflammatory cytokine IL-6, C-reactive protein, D-dimer.

Influence of exogenous and endogenous factors on the quality of the preanalytical stage of laboratory tests (review of literature).

A literature review in the article presents an analysis of the influence of endogenous and exogenous factors on quality of preanalytical phase of laboratory testing. The review shows significance of external and internal factors influencing blood samples at preanalytical phase of laboratory testing. Among the exogenous factors considered: phlebotomy, test tubes for samples, transportation and storage.

[Age and nosological structure of ophthalmological diseases of patients of the ophthalmological center of Saint-Petersburg in 2015-2019.].

About 1,3 billion people live on our planet with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in the elderlypopulation. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease to blindness and the lack of pathogenetic therapy methods. A retrospective analysis of the long-term dynamics and structure of cases of ophthalmological diseases of patients treated in a large multidisciplinary hospital was carried out.

[Features of the picture of blood cells in elderly persons with primary open-angle glaucoma.].

Around 1,3 billion people live worldwide with visual analyzer disorders such as glaucoma and cataract. These diseases are particularly common among the elderly. From glaucoma every year 10 million people completely lose vision, one of the factors of which is untimely diagnosis.

[Laboratory predictors of glaucoma in patients with middle and old age - a tool to improve the quality of life (literature review).].

There are about 1,3 billion people worldwide with visual disorders such as cataract and glaucoma, the prevalence of which is significantly higher in elder persons. Eye diseases remain a global medical, social and economic problem, associated with both the progression of the disease up to blindness and the lack of pathogenetic therapy methods. Timely detection of pathology is secondary prevention of glaucoma.

[Algorithm to stratify the risk of myocardial infarction in patients with acute coronary syndrome at primary examination.].

The episode of acute coronary syndrome is most often preceded by the development of systemic and local inflammation, which plays a significant role in the pathogenesis of the disease. General clinical blood analysis, directly or indirectly reflecting systemic pathological processes in the patient's body based on quantitative and morphological assessment of blood composition, is one of the most affordable methods of laboratory diagnostics in modern public health. Taking into account the growing number of digital data obtained by diagnosticians from analytical systems, there is a growing potential for the use of machine learning methods to increase the effectiveness of provided diagnostic information in the interests of the patient.

[The value of in vitro diagnostic testing in the provision of medical care to patients with cardiovascular diseases.].

In vitro diagnostics are used at all stages of patient care. The aim of this study was to assess the impact of laboratory examination on clinical decision-making in providing medical care to patients with a cardiovascular profile. We also took into account the level of financing for the laboratory industry in the Russian Federation.

[Evaluation of hyperglycemia impact on outcomes of acute coronary syndrome in elderly and senile patients.].

Acute coronary syndrome (ACS) in elderly and senile patients has a number of features and requires special attention to providing medical care. These patients is associated with significant comorbidity and atypical symptoms in the course of the disease. Diabetes mellitus is a common background disease in patients with ACS.

[Comparative evaluation of scales for the assessment of senile asthenia syndrome in patients with acute coronary syndrome.].

The syndrome of senile asthenia (frailty) in patients with acute coronary syndrome is recognized as one of the risk factors for the development of adverse outcomes after undergoing cardiosurgical interventions, and the search for an optimal method for assessing this syndrome could be a screening to identify patients at increased risk. This study compares two methods for assessing senile asthenia syndrome in patients with acute coronary syndrome, its prevalence in this category of patients, its relationship with clinical characteristics and 1-year mortality after hospitalization. According to the results of the study, senile asthenia syndrome was observed more often in the group of patients older than 75 years.

[Results of troponin I testing by high sensitive method in three age groups of healthy population].

Article is about troponin I testing by high sensitive method in healthy population group. 165 people (employees of hospital) were examined, 71 % - women and 29 % - men. Inclusion criteria were as follows: absence of active complaints at the time of health examination and during the previous 30 days.

[Digoxin in elderly patients: therapeutic drug monitoring to increase the efficiency of therapy (a review)].

The focus of this review is on cardiac and non-cardiac effects of digoxin, a drug used for treating the heart failure, and on link between these effects and the serum digoxin concentration (SDC) in different dosing regimens. Elderly patients are at the spotlight, as they are both at high risk and high potential benefit from digoxin therapy, explaining potential usefulness from SDC monitoring in this cohort of patients. The laboratory and clinical approaches used to prevent digitalis intoxication are reviewed, with regard to their fidelity, clinical value, and practical usefulness.

[THE EXPERIENCE OF DETECTION OF SERUM CARDIO MARKERS IN PATIENTS AFTER PLANNED CORONARY ARTERY GRAFTING].

The article exposes the results of experience of laboratory diagnostic of myocardium infarction in patients subjected to operation of coronary artery bypass grafting. The study included patients hospitalized in a planned order and with further coronary artery bypass grafting carried out.

[The lipids peroxidation and atherogenesis level in aged patients].

The data presented have described the diagnostic possibilities of chemioluminescence' intensity research in patients with atherosclerosis. The investigation has been conducted on 48 aged patients with ischemic heart disease. Statistically significant correlation between chemoluminescence' intensity and atherogenesis factor as an atherosclerosis indicator was revealed.

[The definition of chemiluminescence intensity in experimental model of premature senescence].

The diagnostic possibilities of chemiluminescence's intensity research for premature senescence prognosis are described in this article. The definition of chemiluminescence's intensity enables to reveal the individuals stable to processes of premature senescence in the model of acute radiation.

[Brain natriuretic peptide detection in patients with chronic heart failure of elderly and senile age].

This article describes the diagnostic possibilities of research of NT-BNP level in blood of the patients of elderly and senile age with congestive heart failure. Statistically significant correlation between BNP concentration and a functional class of heart insufficiency is revealed. Definition of BNP level enables to diagnose differentially the difficult forms of congestive heart failure.

[Modern approaches to correction and prophylaxis of premature aging using adaptogenes of plant origin].

Last years, the big attention is given studying of the methods promoting increase of the immune status of an organism, got under influence of extreme factors, in particular, ionas radiations. In this connection perspectivity of application of laboratory diagnostics for testing a degree of defeat of immune system and application phytoadaptogenes is proved, namely: tinctures of a Panacis ginseng, Schizandrae chinensis, an extract Elaetherococcus for correction of such conditions.

[Predictive value of variability of the laboratory indices in the development of premature aging].

Diagnostics of those or other pathological processes is connected with an estimation of deviations of corresponding laboratory indexes from their reference values. Results of the research enable to use the indexes of individual variability of laboratory tests as a criterion of individual resistance, which has a prognosis value in studying of age pathology. It also essentially expands ideas about activation of the peroxide oxidation of the lipids as the basic trigger factor of the accelerated aging.

[Biosynthesis of nucleic acids and proteins in different time periods of development in experimental myocarditis].

Biosynthesis of DNA, RNA and protein was studied in rat myocardium within 1, 3, 5, 7, 14, 21 and 28 days after administration of adrenaline toxic doses (300 mg/100 g of body mass). Synthesis of DNA was activated within 1-7 days, of total proteins--within 1-14 days, of RNA--within 1-"1 days, of action and myosin in myocardium--within 3-21 days. All the patterns studied were normalized within the subsequent periods (21-28 days) although they exceeded the control values.