Publications by authors named "Rukang Zheng"
Article Synopsis
- Osteoarthritis (OA) is a leading cause of disability in older adults, marked by cartilage damage and extra bone growth; phillyrin, an extract from forsythia known for its antibacterial and anti-inflammatory properties, is being studied for its potential to combat OA.
- The research aims to explore the anti-inflammatory and anti-aging effects of phillyrin on mouse chondrocytes influenced by IL-1β, while also examining its impact on a mouse model of osteoarthritis.
- Key targets identified for phillyrin's therapeutic effects include NFE2L2 (NRF2), NFKB1, TLR4, and SERPING1; in vitro experiments showed that phillyrin reduces pro-inflammatory factors and protects against
Article Synopsis
- Osteoarthritis (OA) is a degenerative disease marked by inflammation and degradation of the extracellular matrix, leading to personal disability and societal issues; Lycopodium japonicum Thunb. (LJT), a plant known for its anti-inflammatory and analgesic properties, is used in traditional medicine for treating OA and related conditions.
- The study aims to investigate the properties of LJT in mouse chondrocytes and an OA mouse model, focusing on its anti-apoptotic, anti-inflammatory, and anti-senescence effects to determine its mechanisms as an anti-osteoarthritis agent.
- Results identified key targets for LJT's action against OA, including AKT1, PTGS2, and ESR1; molecular docking suggested a
Intervertebral disc degeneration (IVDD), a common degenerative disc disease, is a major etiological factor for back pain, affecting a significant number of middle-aged and elderly individuals worldwide. Thus, IVDD is a major socio-economic burden. The factors contributing to the complex IVDD etiology, which has not been elucidated, include inflammation, oxidative stress, and natural aging.
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