Morules and β-catenin predict POLE mutation status in endometrial cancer: A pathway to more cost-effective diagnostic procedures.

Objectives: The characterization of DNA polymerase epsilon (POLE) mutations has transformed the classification of endometrial endometrioid carcinomas (EECs), highlighting the need for efficient identification methods. This study aims to examine the relationship between distinct morphologic features-namely, squamous morules and squamous differentiation (SD), as well as β-catenin expression-and the POLE mutation status in endometrial cancer (EC).

Methods: Our study included 35 POLE-mutated (POLEmut) EC cases and 395 non-POLEmut EEC cases.

Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study.

Objectives: To explore the differences in clinical characteristics, prognosis, and risk factors between type I and type II endometrial cancer (EC).

Materials And Methods: We retrospectively collected EC patients diagnosed with type I or type II EC from 2009 to 2021 in the First Affiliated Hospital of Zhengzhou University.

Results: In total, 606 eligible EC patients (396 type I, and 210 type II) were included.

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway.

Progestin is commonly used for young patients suffering from endometrial hyperplasia or cancer. However, there is approximately 30% failure rate with unclear mechanism. We investigated if Nrf2-survivin pathway contributes the progestin resistance (PR) in this setting.