Outcomes of Long Bones Treated With Carbon-Fiber Nails for Oncologic Indications: International Multi-institutional Study.

Background: Intramedullary nail fixation is commonly used for prophylactic stabilization of impending and fixation of complete pathological fractures of the long bones. However, metallic artifacts complicate imaging evaluation for bone healing or tumor progression and postoperative radiation planning. Carbon-fiber implants have gained popularity as an alternative, given their radiolucency and superior axial bending.

Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma.

Background: Survival in patients who have Ewing sarcoma is correlated with postchemotherapy response (tumor necrosis). This treatment response has been categorized as the response rate, similar to what has been used in osteosarcoma. There is controversy regarding whether this is appropriate or whether it should be a dichotomy of complete versus incomplete response, given how important a complete response is for in overall survival of patients with Ewing sarcoma.

Impact of Steroid Only Induction on Rejection in Simultaneous Liver-Kidney Transplantation.

The occurrence of simultaneous liver kidney transplantation has greatly increased; however, the ideal induction and maintenance immunosuppression remains unknown. This evaluation aimed to determine if corticosteroid only induction in simultaneous liver kidney transplant recipients provided adequate prophylaxis against rejection when compared to basiliximab. This was a single center, retrospective, cohort study of adult simultaneous liver kidney transplant recipients from June 2010 to June 2019 receiving corticosteroid only (N = 41) or basiliximab (N = 42) induction.

Trends in glycemic control, cardiovascular risk factors and chronic complications of type 2 diabetes, 2012-2016, in a healthcare area of Barcelona.

Aims: This study aimed to analyse the evolution of the metabolic control, cardiovascular risk factors and chronic complications in a Type 2 Diabetes (T2D) population in a healthcare area of Barcelona.

Methods: We carried out a comparative study of T2D patients (20.457) between 2012 and 2016 (data recorded in the "Electronic Clinical-Station in Primary Care") concerning: age, gender, body mass index (BMI), arterial blood pressure (BP), HbA1c, LDL-Cholesterol, smoking, heart failure (HF), micro and macrovascular complications.

The coastal waters of the south-east Bay of Biscay a dead-end for neustonic plastics.

Numerical models point to the south-east Bay of Biscay as a convergence area for floating particles, including plastics. The few existing studies on plastic abundance in the area mainly focus on open waters and yet information on the coastal area is limited. To fill this gap, neustonic samples were taken along the coastal waters of the south-east Bay of Biscay (2017-2020) to define the spatial distribution of plastic abundances and composition.

Baseline Total Metabolic Tumor Volume is Prognostic for Refractoriness to Immunochemotherapy in DLBCL: Results From GOYA.

Introduction: A good response to initial therapy is key to maximizing survival in patients with diffuse large B-cell lymphoma (DLBCL), but patients with chemorefractory disease and early progression have poor outcomes.

Patients And Methods: Data from the GOYA study in patients with DLBCL who received first-line rituximab or obinutuzumab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) were analyzed. Positron emission tomography/computed tomography (PET/CT)-derived characteristics associated with total metabolic tumor volume (TMTV) and clinical risk factors for primary chemorefractory disease and disease progression within 12 months (POD12) were explored.

LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer.

Ligand-dependent corepressor (LCOR) mediates normal and malignant breast stem cell differentiation. Cancer stem cells (CSCs) generate phenotypic heterogeneity and drive therapy resistance, yet their role in immunotherapy is poorly understood. Here we show that immune-checkpoint blockade (ICB) therapy selects for LCOR CSCs with reduced antigen processing/presentation machinery (APM) driving immune escape and ICB resistance in triple-negative breast cancer (TNBC).

First assessment of floating marine litter abundance and distribution in the Bay of Biscay from an integrated ecosystem survey.

In the Bay of Biscay, regional monitoring programmes and data on abundance and distribution of floating marine litter are scarce, contrary to many other European marine regions. Here, a joint analysis of multiyear observations (2017-2019) of floating micro and macrolitter and oceanographic conditions was conducted for the Bay of Biscay by combining microlitter samplings with neuston nets and vessel-based macrolitter observations. Results show spatiotemporal abundance and distribution patterns.

Modelling the distribution of fishing-related floating marine litter within the Bay of Biscay and its marine protected areas.

Sea-based sources account for 32-50 % of total marine litter found at the European basins with the fisheries sector comprising almost 65 % of litter releases. In the south-east coastal waters of the Bay of Biscay this figure approaches the contribution of just the floating marine litter fraction. This study seeks to enhance knowledge on the distribution patterns of floating marine litter generated by the fisheries sector within the Bay of Biscay and in particular on target priority Marine Protected Areas (MPAs) to reinforce marine litter prevention and mitigation policies.

HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02).

Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label, single-arm, phase I clinical trial, enrolling 15 early-treated HIV-1-infected individuals, testing the combination of the histone deacetylase inhibitor romidepsin as a latency-reversing agent and the MVA.HIVconsv vaccine.

Prototype Selection Method Based on the Rivality and Reliability Indexes for the Improvement of the Classification Models and External Predictions.

Prototype or instance selection techniques is an important field of research in knowledge discovery, data mining, and machine learning. In QSAR, the use of prototype selection techniques in the preprocessing stage of the construction of the QSAR models favors the data set curation, improving the interpretability and accuracy of the models as well as the performance of the algorithms. In this paper, we propose an efficient method for prototype selection to be used in the preprocessing stage of the construction of QSAR classification models.

Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80.

[This corrects the article DOI: 10.1016/j.eclinm.

Building Highly Reliable Quantitative Structure-Activity Relationship Classification Models Using the Rivality Index Neighborhood Algorithm with Feature Selection.

Dimensionality reduction of the data set representation for the construction of the quantitative structure-activity relationship classification models is an important research subject for the interpretability of the models and the computational cost efficiency of the classification algorithms. Feature selection techniques are appropriate as only a short number of relevant features should be used in the classification process because irrelevant and redundant features should be discarded, the same as the noninterpretable ones. In this paper, we propose an embedded feature selection technique for the construction of classification models using the rivality index neighborhood (RINH) algorithm.

Asthma prevalence and risk factors in school children: The RESPIR longitudinal study.

Objectives: To analyze the incidence of wheezing in the first six years of life; the prevalence of asthma at six years of age; and the associated risk factors, in a population from Valencia, Spain.

Methods: A prospective longitudinal study was made of a cohort of 636 newborn infants, with follow-up of the clinical records and the completion of questionnaires up to the age of six years.

Results: The prevalence of asthma at six years of age was 12.

Medication adherence to rivaroxaban and dabigatran in patients with non-valvular atrial fibrillation: a meta-analysis.

Several real-world studies have evaluated adherence to direct acting oral anticoagulants in patients with non-valvular atrial fibrillation (NVAF); however, these studies have not been systematically summarized. We performed a meta-analysis to compare adherence to rivaroxaban versus dabigatran therapy in United States (US) patients with NVAF in a real-world setting. Medline and Scopus were searched from January 2010 to August 2018 using keywords and MeSH terms related to adherence and oral anticoagulants.

Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study).

Background: Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy.

Methods: BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63.HIVconsv prime and MVA.

Saddle pulmonary embolism and in-hospital mortality in patients with cancer.

Purpose: Saddle pulmonary embolism (PE) has been associated with an increased risk of 1 year mortality when compared to non-saddle PE among patients with cancer. We sought to evaluate the association between saddle PE and in-hospital outcomes among patients with comorbid cancer.

Methods: The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute PE.

Study of the Applicability Domain of the QSAR Classification Models by Means of the Rivality and Modelability Indexes.

The reliability of a QSAR classification model depends on its capacity to achieve confident predictions of new compounds not considered in the building of the model. The results of this external validation process show the applicability domain (AD) of the QSAR model and, therefore, the robustness of the model to predict the property/activity of new molecules. In this paper we propose the use of the rivality and modelability indexes for the study of the characteristics of the datasets to be correctly modeled by a QSAR algorithm and to predict the reliability of the built model to prognosticate the property/activity of new molecules.

Advantages of Relative versus Absolute Data for the Development of Quantitative Structure-Activity Relationship Classification Models.

The appropriate selection of a chemical space represented by the data set, the selection of its chemical data representation, the development of a correct modeling process using a robust and reproducible algorithm, and the performance of an exhaustive training and external validation determine the usability and reproducibility of a quantitative structure-activity relationship (QSAR) classification model. In this paper, we show that the use of relative versus absolute data in the representation of the data sets produces better classification models when the other processes are not modified. Relative data considers a reference frame to measure the chemical characteristics involved in the classification model, refining the data set representation and smoothing the lack of chemical information.

[Lithogenic risk index in urinary lithiasis patients and their evolution after treatment.].

Objective: To determine the lithogenic risk index and its evolution after treatment of paraguayan lithiasic patients.

Methods: This experimental study of temporal series included 28 lithiasic patients of both sexes that attended to the Instituto de Prevision Social in 2012. Basal evaluation included metabolic study and urinary saturation indexes determined by EQUIL software.

Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.

Introduction And Objectives: Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin).

Methods: Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase).

[Lithogenic risk in patients from Paraguay with urolithiasis].

Unlabelled: The lithogenic risk profile is a graphical representation of metabolic factors and urinary saturation involved in the stone formation with their respective critical values.

Aim: To determine the lithogenic risk profile in patients with urolithiasis.

Material And Methods: Personal data such as anthropometric, history of diseases and family history of urolithiasis were recorded.

[Enteric parasitic disease in children under 5 years of age, indigenous and non-indigenous, from rural communities in Paraguay].

Background: Official figures of mortality in children under five years of age in the Americas, report that infectious and parasitic diseases caused most of the deaths.

Objective: To evaluate the frequency of intestinal parasites in vulnerable children, indigenous and non-indigenous, and their socio-environmental characteristics.

Patients And Methods: We evaluated 247 children under five years of age, of both sexes.