Antimicrobial polyketides from an endophytic fungus HJ-7 from Hance.

Eleven polyketide derivatives, including two new compounds, xanthoradone D () and arisochromophilone (), were isolated from HJ-7, a Chinese medicinal plant Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated.

Lignans and phenols with potential anti-inflammatory effect from the stems of Mallotus paxii Pamp.

Phytochemical investigation of the stems of Mallotus paxii Pamp. led to the isolation and identification of four new compounds, including three neolignans (1-3) and one phenol (13), along with eight known neolignans (4-12) and one known phenol (14). Their structures were determined by spectroscopic methods, including NMR, MS and ECD analyses.

Two new polyketone derivatives from the mangrove endophytic fungus GXNU TH4b.

Two new polyketones, exserone B () and cytosporone F (), along with three known metabolites, were isolated from the mangrove endophytic fungus TH4b. The structures of and were determined by detailed NMR, and MS spectroscopic data. The absolute configurations of and were determined by single crystal X-ray diffraction analysis and the combination of experimental ECD and computational ECD, respectively.

Oleanane-type triterpenoids from Sabia limoniacea and their anti-inflammatory activities.

Eighteen new oleanane-type triterpenoids were isolated from the stems of Sabia limoniacea, including sabialimon A (1), a triterpenoid with an unprecedented 6/6/6/7/7 pentacyclic skeleton and seventeen undescribed triterpenoids, sabialimons B-R (2 - 18), along with six previously described analogs (19 - 24). Their structures were fully elucidated via extensive spectroscopic analysis including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), experimental electronic circular dichroism measurements and X-ray crystallographic studies. Compound 1 is the first triterpenoid that possesses a rare ring system (6/6/6/7/7) with an oxygen-bearing bridge between C-17 and C-18 and a hemiketal form at C-17, which is generated a larger ring by the degradation of C-28 and D/E-ring expansion.

Isolation and Characterization of Antimicrobial Metabolites from the -Associated Fungus sp. GDGJ-N37.

Chemical investigation of sp. GDGJ-N37, a -associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine () and 7-methoxyl--isoamylsclerotiorinamine (), and four known azaphilones (-), together with two new chromone derivatives, penithochromones X and Y ( and ). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis.

Diagnostic value of upper airway morphological data based on CT volume scanning combined with clinical indexes in children with obstructive sleep apnea syndrome.

Background And Purpose: Early diagnosis is important for treatment and prognosis of obstructive sleep apnea (OSA)in children. Polysomnography (PSG) is the gold standard for the diagnosis of OSA. However, due to various reasons, such as inconvenient implementation, less equipped in primary medical institutions, etc.

Triterpenoids from the Leaves of and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.

Four new dammarane triterpenoid saponins cypaliurusides - (-) and eight known analogs (-) were isolated from the leaves of . The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit.

Megastigmane glycosides from Streblus ilicifolius (S.Vidal) Corner and their anti-inflammatory activity.

Twelve undescribed megastigmane glycosides, streilicifolosides A-L (1-12), together with 8 known analogues (13-21) were isolated from the leaves of Streblus ilicifolius (S.Vidal) Corner. Their plannar structures were elucidated using extensive NMR spectroscopic methods (1D and 2D-NMR spectroscopy), and HRESIMS spectroscopic data analyses.

Two new cytochalasins from the endophytic fungus sp. GDGJ-77B.

Two new open-chain cytochalasins, xylarchalasins A and B ( and ), together with six known analogues (-), were isolated from the endophytic fungus sp. GDGJ-77B from the Chinese medicinal plant . Their structures were elucidated on the basis of comprehensive spectroscopic analysis.

Cycloaspeptide H, a cyclopentapeptide from the endophytic fungus .

One new cyclopentapeptide, cycloaspeptide H (), featuring a serine residue, along with seven known compounds (-), was isolated from the endophytic fungus GDGJ-227. The planar structure of was elucidated by a comprehensive analysis of NMR and MS spectroscopic spectra, and the absolute configuration was determined by single-crystal X-ray diffraction (Cu Kα) analysis. Compounds and displayed antibacterial activities against and with MIC values ranging from 12.

Cytotoxic cardiac glycosides from the root of Streblus asper.

Bioassay-guided separation of the root of Streblus asper led to the identification of six undescribed cardiac glycosides, including a rare cardiac glycoside dimer, along with twelve previously reported analogues. Their structures were determined on the basis of analyses of spectroscopic methods (1D and 2D-NMR spectroscopy), high-resolution electrospray ionization mass spectrometry (HRESIMS), circular dichroism (CD), and comparison of their spectroscopic data with previously reported data. Regarding their cytotoxic activities, microculture tetrazolium assays showed that all isolated cardiac glycosides strongly inhibited MCC-803, T24, SKOV-3, HepG2, Wi-38, and A549 cancer cell lines, with IC values ranging from 0.

Polyketide Derivatives, Guhypoxylonols A-D from a Mangrove Endophytic Fungus sp. GXNU-Y45 That Inhibit Nitric Oxide Production.

Four undescribed compounds, guhypoxylonols A (), B (), C (), and D (), were isolated from the mangrove endophytic fungus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of - were elucidated based on analysis of HRESIMS and NMR spectroscopic data.

A new lactone from mangrove endophytic fungus sp. GXNU-A9.

A new lactone, asperlactone A (), and four known lactone derivatives - were isolated from the mangrove endophytic fungus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data.

Three new andrastin derivatives from the endophytic fungus .

Three new andrastin derivatives, 10-formyl andrastone A (), 10-demethylated andrastone A () and andrastin G (), together with four known andrastin analogues (-) were isolated from an endophytic fungus . Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound exhibited significant antibacterial activity against B with an MIC value of 6.

Bioactivity-guided isolation of anti-inflammatory constituents from the bark of Streblus zeylanicus.

Based on anti-inflammatory activity to evaluate the effects to the release of NO, bio-assay guided separation of the bark of Streblus zeylanicus led to identify fifteen compounds, including four new terpenes (1, 2, 9, and 10), one new pentanoid glycoside (12), one new rumenic ester (13), together with nine known compounds (3-8, 11, 14, and 15). Their structures were elucidated using extensive NMR and HRESIMS spectroscopic data analyses. The stereochemistry of compound 10 was established by comparing the calculated and experimental ECD spectroscopic data.

A new sesquiterpene from mangrove endophytic fungus sp. GXNU-MA1.

A new sesquiterpene, gxsespene A (1), and four known sesquiterpene derivatives were isolated from the mangrove endophytic fungus sp. GXNU-MA1. Their structures were elucidated based on high-resolution electrospray ionization mass spectroscopy (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data.

A new depsidone derivative from mangrove endophytic fungus sp. GXNU-A9.

A new tetracyclic depsidone derivative, guanxidone A (), together with three known metabolites -, was isolated from the mangrove endophytic fungus sp. GXNU-A9. The structure of compound was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data.

3,4--Dammarane Triterpenoid Saponins with Anti-Inflammatory Activity Isolated from the Leaves of .

is commonly used for the prevention and treatment of hypertension, diabetes, and inflammation in South China. Although research on the anti-inflammatory effects of leaves has been reported, no active anti-inflammatory compounds have been identified. In the present study, RAW 264.

Cytochalasins from endophytic sp. GDG-118.

The plant , possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus sp. GDG-118 was fermented and extracted with methanol.

Two new phthalide derivatives from the endophytic fungus isolated from .

Two new phthalide derivatives, (-)-3-carboxypropyl-7-hydroxyphthalide () and (-)-3-carboxypropyl-7-hydroxyphthalide methyl ester (), were isolated from the endophytic fungus isolated from the Chinese medicinal plant . Their structures were elucidated using spectroscopic methods, mainly on 1D and 2D NMR. Compound exhibited medium antibacterial activities against and with MIC values of 12.

Anti- Indole-Diterpenoids and C-25 Epimeric Steroids From the Marine-Derived Fungus .

A systematic chemical exploration of the marine-derived fungus led to the isolation of four indole-diterpenoid derivatives (-), including new penijanthines C and D ( and ), and a pair of new steroidal epimers, penijanthoids A and B ( and ). The calculated ECD spectra and Snatzke's method for the new compound were carried out to determine its absolute configuration. The absolute configuration of was established by X-ray diffraction and calculated ECD methods for the first time.

Cytotoxic Activity and Related Mechanisms of Prenylflavonoids Isolated from Mallotus conspurcatus Croizat.

Five prenylflavonoids, 6-prenylnaringenin (1), 8-prenylnaringenin (2), 7-O-methyl-8-prenylnaringenin (3), 7-O-methyl-6-prenylnaringenin (4), and 4'-O-methyl-6-prenylnaringenin (5), were isolated from the traditional herb Mallotus conspurcatus Croizat (Euphorbiaceae). Compounds 1-5 revealed cytotoxic activity against cervical cancer (HeLa) cells with IC values ranging from 10.08 to 60.