Publications by authors named "Ruiyun Chen"

Objective: This study aims to investigate the feasibility of employing artificial intelligence models for the detection and localization of cervical lesions by leveraging deep semantic features extracted from colposcopic images.

Methods: The study employed a segmentation-based deep learning architecture, utilizing a deep decoding network to integrate prior features and establish a semantic segmentation model capable of distinguishing normal and pathological changes. A two-stage decision model is proposed for deep semantic feature mining, which combines image segmentation and classification to categorize pathological changes present in the dataset.

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  • * The study explores multidimensional photon detection to boost the efficiency of generating random numbers from individual photon events, which is key to increasing overall generation rates.
  • * Using advanced technology, they successfully extract up to 20 bits per photon detection and achieve a random number generation rate of 2.067 Gbps, representing a significant technical advancement.
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  • Gene duplication is common in evolution, but the reasons some genes are lost or retained remain unclear; the study focuses on the trigger factor (TF), a ribosome-associated chaperone typically found as a single copy in most bacteria.
  • The research shows that bacteria with multiple TF homologs usually have one complete TF copy, while others are missing the important N-terminal domain, which binds to ribosomes and is crucial for its function.
  • Overproducing TF leads to negative effects on cell function and protein production, suggesting that the gene's dosage must be carefully regulated; this finding helps explain why bacteria maintain mainly a single copy of TF despite gene duplication events.
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  • * Experimental analyses using methods like qRT-PCR and Western blotting show that higher ABL2 levels in GC cells contribute to greater proliferation, migration, and invasion abilities, linked to proteins such as MMP2 and MMP9.
  • * The study suggests that ABL2 may activate specific signaling pathways (TGF-β/SMAD2/3 and YAP), which enhance processes like epithelial-mesenchymal transition (EMT) in GC cells, suggesting its potential role as a therapeutic target.
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The achievement of size uniformity and monodispersity in perovskite quantum dots (QDs) requires the implementation of precise temperature control and the establishment of optimal reaction conditions. Nevertheless, the accurate control of a range of reaction variables represents a considerable challenge. This study addresses the aforementioned challenge by employing manganese (Mn) doping to achieve size uniformity in CsPbBr perovskite QDs without the necessity for the precise control of the reaction conditions.

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This study explored how germination influences the starch digestion and intestinal fermentation characteristics of brown rice noodle. The study began with starch digestion tests to assess how germination affects starch digestibility in brown rice noodles, revealing an increase in rapidly digestible starch content and a decrease in resistant starch content. Subsequently, an human fecal fermentation model was used to simulate the human intestinal environment, showing that germination altered pH levels and the production of short-chain fatty acids, particularly by increasing propionate while decreasing acetate and butyrate.

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Brown rice noodles are increasingly favored by consumers for their health benefits; however, their development is hindered by their poor edible qualities. The effect of germination on the cooking, textural, organoleptic and nutritional qualities of brown rice pasta was investigated. In comparison to ungerminated brown rice noodles, germination resulted in a shorter cooking time, reduced cooking losses, and decreased hardness and adhesion of noodles as well as reduced bitter taste.

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Determining the correlation between the size of a single quantum dot (QD) and its photoluminescence (PL) properties is a challenging task. In the study, we determine the size of each QD by measuring its absorption cross section, which allows for accurate investigation of size-dependent PL blinking mechanisms and volume scaling of the biexciton Auger recombination at the single-particle level. A significant correlation between the blinking mechanism and QD size is observed under low excitation conditions.

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  • - Research highlights the unique nonlinear optical properties of two-dimensional materials like twisted spiral MoTe nanopyramids and supertwisted WS, which show strong second- and third-harmonic generation.
  • - The study investigates photoluminescence (PL) spectra of supertwisted spiral WS, revealing unusual behavior where PL intensity increases almost linearly with the number of layers, suggesting changes in material interactions.
  • - Findings also indicate that power-dependent PL spectra exhibit smaller power exponents in supertwisted WS compared to conventional multilayer WS, pointing to differences in interlayer spacing and interactions, which could impact future optoelectronic device development.
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The chaperone 70 kDa heat shock protein (Hsp70) is important for cells from bacteria to humans to maintain proteostasis, and all eukaryotes and several prokaryotes encode Hsp70 paralogs. Although the mechanisms of Hsp70 function have been clearly illuminated, the function and evolution of Hsp70 paralogs is not well studied. DnaK is a highly conserved bacterial Hsp70 family.

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  • * This paper introduces a new quantum imaging technique that utilizes quantum compressed sensing to take advantage of the correlations between entangled photons and their random generation, allowing for more effective imaging.
  • * The proposed method successfully captures images of a target rotating at 10 kHz while achieving a significant data compression rate of 10, marking a significant step toward practical quantum imaging applications.
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Background: Exercise is crucial for pulmonary rehabilitation and improving the prognosis of lung transplantation (LTx) patients. However, many LTx patients in China have low exercise tolerance and compliance, and the reasons behind these challenges have not been fully elucidated. Therefore, this qualitative research aims to identify the barriers to and facilitators of exercise rehabilitation in LTx patients.

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Surface-enhanced Raman scattering (SERS) has garnered substantial attention due to its ability to achieve single-molecule sensitivity by utilizing metallic nanostructures to amplify the exceedingly weak Raman scattering process. However, the introduction of metal nanostructures can induce a background continuum which can reduce the ultimate sensitivity of SERS in ways that are not yet well understood. Here, we investigate the impact of laser irradiation on both Raman scattering and backgrounds from self-assembled monolayers within nanoparticle-on-mirror plasmonic nanocavities with variable geometry.

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Long non-coding RNAs (lncRNAs) have a vital potential in premature delivery. This research was intended to explore PSMA3-AS1's role in premature delivery as well as its possible molecular mechanism. We enrolled 100 premature delivery patients and 100 term patients.

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Almost all colloidal quantum dots (QDs) exhibit undesired photoluminescence (PL) blinking, which poses a significant obstacle to their use in numerous luminescence applications. An in-depth study of the blinking behavior, along with the associated mechanisms, can provide critical opportunities for fabricating high-quality QDs for diverse applications. Here the blinking of a large series of colloidal QDs is investigated with different surface ligands, particle sizes, shell thicknesses, and compositions.

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Being characterized by the self-adaption and high accuracy, the deep learning-based models have been widely applied in the 1D spectroscopy-related field. However, the "black-box" operation and "end-to-end" working style of the deep learning normally bring the low interpretability, where a reliable visualization is highly demanded. Although there are some well-developed visualization methods, such as Class Activation Mapping (CAM) and Gradient-weighted Class Activation Mapping (Grad-CAM), for the 2D image data, they cannot correctly reflect the weights of the model when being applied to the 1D spectral data, where the importance of position information is not considered.

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Background: More lung cancer cases are becoming diagnosed earlier in recent years. The diagnosis is often accompanied by fear of progression (FoP). There is a clear research gap in the existing literature on FoP and the most frequent concerns in newly diagnosed lung cancer patients.

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Infrared up-conversion single-photon imaging has potential applications in remote sensing, biological imaging, and night vision imaging. However, the used photon counting technology has the problem of long integration time and sensitivity to background photons, which limit its application in real-world scenarios. In this paper, a novel passive up-conversion single-photon imaging method is proposed, in which the high frequency scintillation information of a near infrared target is captured by using the quantum compressed sensing.

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Organic-inorganic metal halide perovskites have been emerging as potential candidates for lightweight photovoltaic applications in space. However, fundamental physics concerning the effect of atmosphere on the radiative and nonradiative recombination in perovskites remains far from well understood. Here, we investigate the creation and annihilation of nonradiative recombination centers in individual CHNHPbI perovskite crystals by controlling the atmospheric conditions.

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The optical interference effect originating from the multiple reflections between the two-dimensional (2D) materials and the substrates has been used to dramatically enhance their Raman signal. However, this effect in the hybrid structures of colloidal quantum dots (QD) coupled to 2D materials is always overlooked. Here we theoretically prove that the photoluminescence (PL) intensities of the QD films in the QD-2D hybrid structures can be strongly enhanced and modulated by the optical interference effect between QD and 2D interfaces, breaking the inherent standpoint that PL intensities of the QD films are always prominently quenched in these hybrid structures.

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Photoblinking and photobleaching are commonly encountered problems for single-photon sources. Numerous methods have been devised to suppress these two impediments; however, either the preparation procedures or the operating conditions are relatively harsh, making them difficult to apply to practical applications. Here, we reported giant suppression of both photoblinking and photobleaching of a single fluorescent molecule, terrylene, via the utilization of hexagonal boron nitride (h-BN) flakes as substrates.

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Au nanoparticles are attractive contrast agents for noninvasive living tissue imaging with deep penetration because of their strong two-photon photoluminescence (TPPL) intensity and excellent biocompatibility. However, the inevitable phototoxicity and huge auto-fluorescence are consistently associated with laser excitation. Therefore, enhancement of TPPL intensity and suppression of backgrounds are always highly desired under the demand of reducing excitation powers.

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The interaction between light and metal nanoparticles enables investigations of microscopic phenomena on nanometer length and ultrashort timescales, benefiting from strong confinement and enhancement of the optical field. However, the ultrafast dynamics of these nanoparticles are primarily investigated by multiphoton photoluminescence on picoseconds or photoemission on femtoseconds independently. Here, we presented two-photon photoluminescence (TPPL) measurements on individual Au nanobipyramids (AuNP) to reveal their ultrafast dynamics by double-pulse excitation on a global timescale ranging from subfemtosecond to tens of picoseconds.

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van der Waals (vdW) heterostructures of transition metal dichalcogenides (TMDCs) provide an excellent paradigm for next-generation electronic and optoelectronic applications. However, the reproducible fabrications of vdW heterostructure devices and the boosting of practical applications are severely hindered by their unstable performance, due to the lack of criteria to assess the interlayer coupling in heterostructures. Here we propose a physical model involving ultrafast electron transfer in the heterostructures and provide two criteria, η (the ratio of the transferred electrons to the total excited electrons) and ζ (the relative photoluminescence variation), to evaluate the interlayer coupling by considering the electron transfer in TMDC heterostructures and numerically simulating the corresponding rate equations.

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