Pigmented Skin Disorders in High-Altitude: Cross-Sectional Epidemiological Analysis in the General Population of Lhasa, China.

Background: Previous studies showed the prevalence of melasma, plateau facial telangiectasia, and vitiligo varied in different regions but were absent in high-altitude areas.

Aims: To investigate the prevalence of three common pigmented skin disorders (melasma, plateau facial telangiectasia, and vitiligo) among the general population in Lhasa, aiming to provide a scientific basis for their prevention and management in high-altitude areas.

Methods: From May 2021 to October 2021, multistage stratified cluster random sampling was conducted in Lhasa to carry out a questionnaire and a second on-site physical examination, and the results were statistically analyzed.

Morpho-phylogenetic analyses of two novel edible mushrooms from China and a mini review of (Agaricales, Lyophyllaceae) cultivation and bioactivities.

plays an important role in the natural ecosystem and has significant economic value. Some species of this genus have been cultivated in Asia, America, and Europe. This study describes four edible species of , two of which were newly discovered.

Lattice Anisotropy-Driven Reduction of Phonon Velocities in Black Phosphorus.

Phonon dynamics and transport determine how heat is utilized and dissipated in materials. In 2D systems for optoelectronics and thermoelectrics, the impact of nanoscale material structure on phonon propagation is central to controlling thermal conduction. Here, we directly observe in-plane coherent acoustic phonon propagation in black phosphorus (BP) using ultrafast electron microscopy.

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions.

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications of coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models are presently widely used in neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful and promising alternative model species. Mounting evidence supports the importance of RNA modifications in zebrafish CNS function, providing additional insights into epitranscriptomic mechanisms underlying a wide range of brain disorders.

Mo(CO)-catalyzed reductive coupling reaction to synthesize benzimidazoquinazolinones and dihydroquinazolinoquinazolinones.

A series of benzimidazoquinazolinone and dihydroquinazolinoquinazolinone derivatives were synthesized by deploying a method in which Mo(CO) was used as both reductant and cyclization accelerator. The preliminary anti-cancer activities of the obtained products were measured and several compounds were revealed to exhibit anti-cancer activities.

Optimizing Lasing Performance of CsPbBr Microplates by Regulating Exciton Recombination Dynamics with Pressure.

This study aims to achieve an ultralow lasing threshold in CsPbBr microplates (MPs), a crucial step toward developing electrically driven micro/nanolasers for optics integrated chips. We investigate the lasing behavior of CsPbBr MPs under varying pressures by using static-state photoluminescence (PL), time-resolved PL (TRPL), and first-principles theory calculations based on density functional theory (DFT). Our results reveal that the lasing threshold initially decreases and then increases, with a critical turning point at 0.

Insights into relationship of oxidative potential of particles in the atmosphere and entering the human respiratory system with particle size, composition and source: A case study in a coastal area in Northern China.

Oxidative potential (OP) of particulate matter (PM) is an important indicator of its health effects. However, the relationship between OP and its key influencing factors remains unclear. In this study, size-segregated PM samples were collected in Qingdao, China, with major components and OP of PM thoroughly examined.

Improved ZnWO@NiCoO core-shell nanosheet arrays with regulatory interfaces and electronic redistribution.

ZnWO@NiCoO core-shell nanosheet array composites are synthesized on nickel foam a two-step hydrothermal method. The optimal conditions, including a Ni(NO)·6HO to Co(NO)·6HO molar ratio of 2 : 1, 12 hours reaction time, and 120 °C temperature, yield a specific capacitance of 875 C g at 1 A g. The electrode also maintains 81.

Climate risk analysis of low-altitude tea gardens in central Taiwan using a Bayesian network.

Tea is a vital agricultural product in Taiwan. Due to global warming, the increasing extreme weather events have disrupted tea garden conditions and caused economic losses in agriculture. To address these challenges, a comprehensive tea garden risk assessment model, a Bayesian network (BN), was developed by considering various factors, including meteorological data, disaster events, tea garden environment (location, altitude, tea tree age, and soil characteristics), farming practices, and farmer interviews, and constructed risk assessment indicators for tea gardens based on the climate change risk analysis concept from the Intergovernmental Panel on Climate Change Fifth Assessment Report (IPCC AR5).

Chlamydia trachomatis L2 434/Bu readily activates glycolysis under hypoxia for efficient metabolism.

To understand why Chlamydia trachomatis (Ct) (L2/434/Bu) favors hypoxia, we examined the dynamics of infected cells using a glycolysis-related PCR array and metabolomic analysis, along with the perturbation of nucleotide synthesis. Our findings revealed that, compared to normoxia, hypoxia with infection significantly and selectively upregulates the expression of genes related to glycolysis, glycogen degradation, and the pentose phosphate pathway. Furthermore, hypoxia induced a significant decrease in metabolite levels, particularly methionine-related metabolites, independent of infection, indicating efficient metabolism under hypoxia.

OsO as the Contrast-Generating Chemical Species of Osmium-Stained Biological Tissues in Electron Microscopy.

Electron imaging of biological samples stained with heavy metals has enabled visualization of subcellular structures critical in chemical-, structural-, and neuro-biology. In particular, osmium tetroxide (OsO) has been widely adopted for selective lipid imaging. Despite the ubiquity of its use, the osmium speciation in lipid membranes and the process for contrast generation in electron microscopy (EM) have continued to be open questions, limiting efforts to improve staining protocols and therefore high-resolution nanoscale imaging of biological samples.

A multimodal MRI study of XNKQ acupuncture for limb dysfunction after ischemic stroke: a randomized controlled study protocol.

Introduction: Limb motor dysfunction is one of the challenges in rehabilitation after cerebral ischemic stroke (CIS) and greatly affects the quality of life of patients. This study aims to investigate the central mechanisms of the curative effect with multimodal magnetic resonance imaging (MRI), which will provide additional evidence to support the application of Xingnao Kaiqiao (XNKQ) acupuncture.

Methods And Analysis: This trial is a randomized controlled trial.

New insights into the influences of firework combustion on molecular composition and formation of sulfur- and halogen-containing organic compounds.

Firework (FW) events occur during various festivals worldwide and substantially negatively influence both air quality and human health. However, the effects of FWs on the chemical properties and formation of organic aerosols are far from clear. In this study, fine particulate matter (PM) samples were collected in a suburban area in Qingdao, China during the Chinese Spring Festival.

Study on the Tip Leakage Loss Mechanism of a Compressor Cascade Using the Enhanced Delay Detached Eddy Simulation Method.

The leakage flow has a significant impact on the aerodynamic losses and efficiency of the compressor. This paper investigates the loss mechanism in the tip region based on a high-load cantilevered stator cascade. Firstly, a high-fidelity flow field structure was obtained based on the Enhanced Delay Detached Eddy Simulation (EDDES) method.

Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.

Galectin-3 (Gal-3) is a multifunctional protein that has been linked to fibrosis and inflammation in the cardiovascular system. In this study, we examined the impact of Gal-3 on inflammation and fibrosis in patients with arteriogenic erectile dysfunction (A-ED) and the underlying mechanisms involved. To induce arterial injury, we utilized cuffs on the periaqueductal common iliac arteries of Sprague‒Dawley (SD) rats and administered a high-fat diet to co-induce local atherosclerosis.

The extraction, purification, structural features, bioactivities, and applications of Schisandra chinensis polysaccharides: A review.

Schisandra chinensis, as a famous medicinal and food homologous plant, has a long history of medicinal and dietary therapy. It has the functions of nourishing the kidney, calming the heart, tranquilising the mind, tonifying Qi and producing fluid to relieve mental stress, based on the theory of traditional Chinese medicine. Accumulating evidence has shown that S.

A comprehensive method for quality evaluation of Tibetan medicine Synotis solidaginea by integrating UHPLC-Q-Orbitrap MS chemical profiling and UHPLC-DAD multi-components quantification.

Synotis solidaginea Hand.-Mazz. (SSD) is a commonly used Tibetan medicinal herb with a long history of therapeutic use and has good medicinal value and development and utilization prospects.

Key toxic components and sources affecting oxidative potential of atmospheric particulate matter using interpretable machine learning: Insights from fog episodes.

Fog significantly affects the air quality and human health. To investigate the health effects and mechanisms of atmospheric fine particulate matter (PM) during fog episodes, PM samples were collected from the coastal suburb of Qingdao during different seasons from 2021 to 2022, with the major chemical composition in PM analyzed. The oxidative potential (OP) of PM was determined using the dithiothreitol (DTT) method.

Serum Pharmacochemistry Combined with Network Pharmacology-Based Mechanism Prediction and Pharmacological Validation of Zhenwu Decoction on Alleviating Isoprenaline-Induced Heart Failure Injury in Rats.

Zhenwu decoction (ZWD) is a famous classical formula in the treatment of heart failure (HF) with significant clinical effects. Owing to the complex material basis of ZWD, it is challenging to elucidate the pharmacodynamic substances and pharmacological mechanisms of ZWD against HF. Therefore, an ultrahigh-performance liquid chromatography system coupled with a high-resolution orbitrap mass spectrometry method was used to profile the chemical components and the absorbed prototype constituents in ISO-induced HF rat serum after oral administration of ZWD, and 33 out of 115 compounds were identified.

Therapeutic potential of mesenchymal stem cell-derived exosomal miR-296-5p and miR-337-3p in age-related erectile dysfunction via regulating PTEN/PI3K/AKT pathway.

Mesenchymal stem cells (MSCs) are viewed as an increasingly promising treatment for age-related erectile dysfunction (AED). Owing to the limitations of injecting living cells, the injection of exosomes appears to be a more plausible option. However, whether MSC-derived exosomes (MSC-Exos) improve AED and their potential mechanism remains unknown.

Investigation on Pb adsorption characteristics by AAEMs-rich biochar in aqueous solution: Performance and mechanism.

Biochar derived from soybean straw with AAEMs (alkali and alkaline earth metals) enrichment could efficiently remove heavy metals from contaminated water. In this study, the influences of pyrolysis temperature on the physicochemical property and adsorption performance of soybean straw biochar were investigated. The contributions of different adsorption mechanisms were analyzed quantitatively.