Publications by authors named "Ruiying Liu"

In operational tasks involving cognitive processes and visual guided pointing activities, this paper investigated the effects of icon layout types, visual features and text labels on the performance of visual search through eye tracking technology, taking the layout types of the icon (single row, double row, matrix and circular), visual features (round icon, round inverse colour icon, chamfered square icon, chamfered square inverse colour icon and borderless icon) and text labels (with or without text labels) as experimental variables. The task completion time, the total duration of fixation in AOI (Area of Interest) and the number of fixations in AOI were statistically analysed. Experimental results revealed that the combination of without text label, matrix layout and chamfered square icons could help improve interaction efficiency.

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  • Vibrio cholerae is a major cause of cholera, which leads to significant global mortality, and understanding its virulence regulation could pave the way for new treatments.
  • The study identifies ChsR, a regulator involved in chitosan utilization, as a factor that enhances V. cholerae virulence by upregulating TcpP, which is crucial for producing cholera toxin.
  • Chitosan oligosaccharides were found to inhibit this virulence pathway, and their administration in mice reduced V. cholerae colonization and disease severity, indicating their potential as a therapeutic option for cholera.
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  • Epithelial-to-mesenchymal transition (EMT) facilitates cancer cell invasion and migration, with a key focus on the role of FBXO11 in regulating ZEB1, a critical factor in EMT.* -
  • FBXO11 promotes the degradation of ZEB1 through ubiquitination, and its depletion leads to ZEB1 accumulation, resulting in increased EMT and aggressiveness in non-small cell lung cancer (NSLC) cells.* -
  • High levels of FBXO11 correlate with better prognosis in NSLC, suggesting its potential as a therapeutic target by modulating EMT and ZEB1 stability.*
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  • - The study analyzed the effects of COVID-19 on adenovirus (AdV) infection rates in children in Hangzhou, China, from January 2019 to July 2024, involving over 771,000 samples and finding a 6.10% overall positive rate for AdV.
  • - AdV infection peaked in 2019, especially during summer, but showed fluctuating rates during the COVID-19 pandemic years (2020-2024) with changes in the age groups most affected, shifting from primarily 2-5 year-olds to 5-18 year-olds over time.
  • - The research highlights that COVID-19 has influenced AdV prevalence trends and emphasizes the importance of tailored public health strategies
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Doxorubicin (Dox), a chemotherapeutic agent frequently used to treat cancer, elicits cardiotoxicity, a condition referred to as Dox-induced cardiotoxicity (DIC), and ferroptosis plays a contributory role in its pathophysiology. Fucoidan, a polysaccharide with various biological activities and safety profile, has potential therapeutic and pharmaceutical applications. This study aimed to investigate the protective effects and underlying mechanisms of fucoidan in DIC.

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Adherent-invasive (AIEC) strain LF82, isolated from patients with Crohn's disease, invades gut epithelial cells, and replicates in macrophages contributing to chronic inflammation. In this study, we found that RstAB contributing to the colonization of LF82 in a mouse model of chronic colitis by promoting bacterial replication in macrophages. By comparing the transcriptomes of mutant- and wild-type when infected macrophages, 83 significant differentially expressed genes in LF82 were identified.

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Background: The global spread of COVID-19 has brought immense physiological and psychological distress to students, such as test anxiety and poor sleep quality. This study aims to explore the relationship between COVID-19 stress and test anxiety and the mediating roles of intolerance of uncertainty and sleep quality between them.

Methods: A study was conducted in China during the late stage of the pandemic.

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Uropathogenic Escherichia coli (UPEC) is the most common causative agent of urinary tract infection (UTI). UPEC invades bladder epithelial cells (BECs) via fusiform vesicles, escapes into the cytosol, and establishes biofilm-like intracellular bacterial communities (IBCs). Nucleoside-diphosphate kinase (NDK) is secreted by pathogenic bacteria to enhance virulence.

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Enterohemorrhagic (EHEC) O157:H7 is a common food-borne pathogen that can cause acute diseases. Lysine acetylation is a post-translational modification (PTM) that occurs in various prokaryotes and is regulated by CobB, the only deacetylase found in bacteria. Here, we demonstrated that CobB plays an important role in the virulence of EHEC O157:H7 and that deletion of significantly decreased the intestinal colonization ability of bacteria.

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Objective: Multiple observational studies have demonstrated an association between type 2 diabetes mellitus (T2DM) and chronic liver diseases (CLDs). However, the causality of T2DM on CLDs remained unknown in various ethnic groups.

Methods: We obtained instrumental variables for T2DM and conducted a two-sample mendelian randomization (MR) study to examine the causal effect on nonalcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), viral hepatitis, hepatitis B virus (HBV) infection, and hepatitis C virus (HCV) infection risk in Europeans and East Asians.

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Mitochondrial dynamics are critical in cellular energy production, metabolism, apoptosis, and immune responses. Pathogenic bacteria have evolved sophisticated mechanisms to manipulate host cells' mitochondrial functions, facilitating their proliferation and dissemination. serovar Typhimurium (.

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Enterohemorrhagic (EHEC) is an important foodborne pathogen that infects humans by colonizing the large intestine. The genome of EHEC O157:H7 contains 177 unique O islands (OIs). Certain OIs significantly contribute to the heightened virulence and pathogenicity exhibited by EHEC O157:H7.

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Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver cirrhosis and cancer. Lonicerae flos polysaccharides (LPs) have been shown to be effective in treating metabolic diseases; however, the therapeutic effects and underlying molecular mechanisms of LPs in NAFLD remain unclear.

Purpose: The objective of this study was to investigate the morphological characterization of Lonicerae flos polysaccharides (LPs) and the mechanism of LPs in relieving NAFLD.

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Compact, lightweight, and on-chip spectrometers are required to develop portable and handheld sensing and analysis applications. However, the performance of these miniaturized systems is usually much lower than their benchtop laboratory counterparts due to oversimplified optical architectures. Here, we develop a compact plasmonic "rainbow" chip for rapid, accurate dual-functional spectroscopic sensing that can surpass conventional portable spectrometers under selected conditions.

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We identified and fine-mapped S58, a selfish genetic locus from Asian rice that confers hybrid male sterility in crosses between Asian and African cultivated rice, and found a natural neutral allele in Asian rice lines that will be useful for overcoming S58-mediated hybrid sterility. Hybrids between Asian cultivated rice (Oryza sativa L.) and African cultivated rice (Oryza glaberrima Steud) display severe hybrid sterility (HS), hindering the utilization of strong heterosis in hybrids between these species.

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Alkaline membrane water electrolysis is a promising production technology, and advanced electrocatalyst and membrane electrode design have always been the core technology. Herein, an ion-exchange method and an environmentally friendly in situ green phosphating strategy are successively employed to fabricate Ru-Ru P heterogeneous nanoparticles by using hydroxyapatite (HAP) as a phosphorus source, which is an exceptionally active electrocatalyst for hydrogen evolution reaction (HER). Density functional theory calculation results reveal that strong electronic redistribution occurs at the heterointerface of Ru-Ru P, which modulates the electronic structure to achieve an optimized hydrogen adsorption strength.

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Background: Hyperlipidemia is regarded as a public health matter, and its effective prevention and treatment are urgently required. However, the treatment of hyperlipidemia is still relatively scarce.

Results: Fermented Cerasus humilis fruit (FCHF) had higher total flavonoid, total phenolic, procyanidin, and organic and free amino acid content, and lower total sugar content, than non-fermented C.

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(), one of the most important bacterial pathogens in history, is a gram-negative motile bacterium that causes fatal pandemic disease in humans via oral ingestion of contaminated water or food. This process involves the coordinated actions of numerous regulatory factors. The MerR family regulators, which are widespread in prokaryotes, have been reported to be associated with pathogenicity.

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Purpose: To develop an ultrafast and robust MR parameter mapping network using deep learning.

Theory And Methods: We design a deep learning framework called SuperMAP that directly converts a series of undersampled (both in k-space and parameter-space) parameter-weighted images into several quantitative maps, bypassing the conventional exponential fitting procedure. We also present a novel technique to simultaneously reconstruct T1rho and T2 relaxation maps within a single scan.

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This study aimed to investigate the structure characteristics Lonicera flos polysaccharides (LP) and the protective effects of LP on cyclophosphamide-induced immunosuppression in mice. The results showed the yield and purity of LP was 1.41% and 94.

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The aim of the present study was to examine whether adiponectin could inhibit cardiomyocyte senescence induced by D‑galactose (D‑gal), and whether it functioned via the adiponectin receptor 1 (AdipoR1)/adaptor protein phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1) signaling pathway. For this purpose, the expression levels of adiponectin, AdipoR1 and APPL1 in mouse plasma and myocardial tissues were detected via reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting. An adiponectin‑overexpression plasmid was transfected into D‑gal‑treated H9c2 cells prior to the detection of AdipoR1 and APPL1 expression by RT‑qPCR.

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The bacterium Vibrio cholerae can colonize the human intestine and cause cholera, but spends much of its life cycle in seawater. The pathogen must adapt to substantial environmental changes when moving between seawater and the human intestine, including different availability of carbon sources such as fructose. Here, we use in vitro experiments as well as mouse intestinal colonization assays to study the mechanisms used by pandemic V.

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