Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling.

Background: Postmenopausal osteoporosis and osteoporosis-related fractures are world-wide serious public health problem. Recent studies demonstrated that inhibiting caveolin-1 leads to osteoclastogenesis suppression and protection against OVX-induced osteoporosis. This study aimed to explore the mechanism of caveolin-1 mediating bone loss and the potential therapeutic target.

Apolipoprotein E deficiency potentiates macrophage against in mice with osteomyelitis via regulating cholesterol metabolism.

Introduction: () osteomyelitis causes a variety of metabolism disorders in microenvironment and cells. Defining the changes in cholesterol metabolism and identifying key factors involved in cholesterol metabolism disorders during osteomyelitis is crucial to understanding the mechanisms of osteomyelitis and is important in designing host-directed therapeutic strategies.

Methods: In this study, we conducted and experiments to define the effects of osteomyelitis on cholesterol metabolism, as well as the role of Apolipoprotein E (ApoE) in regulating cholesterol metabolism by macrophages during osteomyelitis.