Publications by authors named "Ruiyan Xiong"
Article Synopsis
- * A discovered peptide, SjDX5-271, promotes M2 macrophage polarization and protects mice from liver IRI, but its effectiveness is lost when macrophages are removed.
- * SjDX5-271 works by inhibiting the TLR4/MyD88/NF-κB signaling pathway, reducing inflammation in IRI, and suggests potential new treatments for IRI and related immune diseases.
The membranes that accurately separate solutes with close molecular weights in harsh solvents are of crucial importance for the development of highly-precise organic solvent nanofiltration (OSN). The physicochemical structures of the membrane need to be rationally designed to achieve this goal, such as customized crosslinked networks, thickness, and pore size. Herein, we synthesize a type of covalent organic polymer (COP) nanofilms with tailor-made thickness and pore structure using a cyclic deposition strategy for precise molecular sieving.
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- Regulatory T cells (Tregs) are important in managing autoimmune and inflammatory diseases, and parasitic helminths can help induce Tregs, presenting a potential therapeutic strategy.
- In this study, a specific peptide (SjDX5-53) was identified from Schistosoma japonicum egg extracts, which enhances Treg production and function while suppressing dendritic cell activation.
- SjDX5-53 demonstrated promising results in mouse models by protecting against autoimmune colitis and psoriasis, underscoring its potential as a new treatment derived from helminth biology.
Background And Aims: Although oral berberine, a natural compound extracted from the Chinese herbal medicine curcumin, has low bioavailability, it is still effective in suppressing obesity; however, the underlying mechanism is unclear. Berberine can bind to bitter-taste receptors (TAS2Rs) in intestinal endocrine secretin tumor (STC-1) cells to promote glucagon-like peptide-1 (GLP-1) secretion. Notably, TAS2Rs also exist in the tuft cells of the gut.
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