Gd-DOTA-PSMA as theranostic bio-gadolinium agent for prostate cancer targeted gadolinium neutron capture therapy.

Purpose: Gadolinium-neutron capture therapy (Gd-NCT) employs isotopically enriched Gadolinium (Gd) and thermal neutrons to selectively target cancer cells. This study investigated the targeting efficacy of Gd-DOTA-PSMA (Prostate-Specific Membrane Antigen) in prostate cancer and explored its potential applications in Gd-NCT.

Methods And Results: We developed Gd-DOTA-PSMA, a novel theranostic bio-gadolinium agent specifically designed for magnetic resonance imaging (MRI)-guided Gd-NCT.

Precision Synthesis and Antiliver Fibrosis Activity of a Highly Branched Acidic 63-Mer Pectin Polysaccharide.

Natural polysaccharides possess various biological functions and have become increasingly important as drug candidates for biomedical development. However, the accessibility to multiple-branched and large-sized acidic polysaccharides with well-defined structures and the identification of related active glycan domains remain challenging. Here, we report the precision synthesis of a highly branched acidic pectin polysaccharide up to a 63-mer containing 10 different glycosidic linkages from .

ACSM3 Suppresses Ovarian Cancer Progression by Inactivating the IFN-γ/JAK/STAT3 Signaling Pathway.

This study aimed to investigate the role of Acyl-CoA medium-chain synthetase 3 (ACSM3) in ovarian cancer (OC) progression. ACSM3 expression in OC tissues and cells is detected by real-time quantitative polymerase chain reaction, immunohistochemistry, or western blot. The influences of ACSM3 on OC progression are assessed in vitro and in vivo experiments.

Pathogenic characterization and drug resistance of neonatal sepsis in China: a systematic review and meta-analysis.

Objectives: Neonatal sepsis is one of the causes of neonatal mortality and bacterial resistance to antibiotics is one of the challenges facing NICU. The aim of this study was to provide a basis for empirical antibiotic selection by comprehensively searching Chinese and non-Chinese databases for studies related to neonatal sepsis pathogenesis conducted in China and synthesizing all the results of the studies conducted in hospitals in China during the period under study METHODS: In this study, we conducted extensive searches of Pubmed, Web of Science, Cochrane, China Biology Medicine disc (SinoMed), China National Knowledge Infrastructure (CNKI) and Wanfang Data. We screened studies published from 2014 to 2023 that were conducted in hospitals in mainland China and involved bacterial blood cultures and susceptibility tests in neonates with neonatal sepsis and extracted the data, which were summarized using Stata 18.

Reduction-Induced Topological Phase Transition to Construct KMn[Fe(CN)] Superstructures for High-Performance Sodium-Ion Batteries.

Potassium manganese-based Prussian blue analogs (KMn-HCF) hold great potential as cathodes for sodium-ion batteries (SIBs). However, the rapid synthesis process often results in excessively small particle sizes, increasing surface area and thereby intensifying side reactions with the electrolyte, which can damage the cathode electrolyte interface (CEI) and diminish cycling stability. Herein, we designed a topological phase transition strategy to assemble small KMn-HCF particles into a 600 nm cubic superstructure.

Enhanced Antitumor Immunity of a Globo H-Based Vaccine Enabled by the Combination Adjuvants of 3D-MPL and QS-21.

Globo H, a specific carbohydrate antigen overexpressed on various human malignancies, has attracted considerable interest as an antigenic target for anticancer vaccine development. Despite several Globo H-based carbohydrate vaccines that have been designed, efficient access to Globo H hexasaccharide antigen and development of powerful adjuvants for enhancing antitumor immunity remain challenging. Herein, we reported a streamlined chemoenzymatic approach to prepare this hexasaccharide antigen, relying on chemical synthesis of Gb5 pentasaccharide by a stereoconvergent [2+3] strategy and subsequent enzymatic α-fucosylation to easily install α1,2-fucose residue.

Building Robust Manganese Hexacyanoferrate Cathode for Long-Cycle-Life Sodium-Ion Batteries.

Manganese Hexacyanoferrate (Mn─HCF) is a preferred cathode material for sodium-ion batteries used in large-scale energy storage. However, the inherent vacancies and the presence of HO within the imperfect crystal structure of Mn─HCF lead to material failure and interface failure when used as a cathode. Addressing the challenge of constructing a stable cathode is an urgent scientific problem that needs to be solved to enhance the performance and lifespan of these batteries.

An ultrasensitive sandwich-type electrochemical immunosensor based on rGO-TEPA/ZIF67@ZIF8/Au and AuPdRu for the detection of tumor markers CA72-4.

Cancer antigen 72-4 (CA72-4) is an important marker of cancer detection, and accurate detection of CA72-4 is urgently required. Herein, a sandwich-type immunosensor was constructed for detection CA72-4 based on composite nanomaterial as the substrate material and trimetal nanoparticles as the nanoprobe. The composite nanomaterial rGO-TEPA/ZIF67@ZIF8/Au used as a selective bio-recognition element were modified on the glassy carbon electrode (GCE) surface.

Robust High-performance Bifunctional Porous Cobalt MOF-Based Catalysts for Overall Water Splitting.

MOF-based materials, as bifunctional catalysts for electrocatalytic water splitting, play an important role in the application and development of clean fuel hydrogen energy. This study presents a series of novel 3D Co-based MOFs with layered networks, including [Co(4,4'-bipy)(aip)(CHOH)·HO] (), [Co(1,3'-bit)(aip)(CHOH)·HO] (), [Co(4,4'-bipb)(aip)] (), and [Co(4,4'-bipe)(aip)·1.5HO] ().

Regulatory roles of miRNA-530 in the post-transcriptional regulation of NF-κB signaling pathway through targeted modulation of IκBα in Sebastesschlegelii.

MicroRNAs (miRNAs) are a crucial type of non-coding RNAs involved in post-transcriptional regulation. The playing essential regulatory roles in the NF-κB signaling pathway and modulate the host immune response to diverse pathogens by targeting IκBα. However, the regulatory mechanism of miRNAs in relation with IκBα in Sebastes schlegelii remains unclear.

Detection of tumor marker CA72-4 with an electrochemical immunosensor based on MnO nanosheets and HNM-AuPtPd nanocomposites.

To accurately detect tumor marker carbohydrate antigen 72-4 (CA72-4) of serum samples is of great significance for the early diagnosis of malignant tumors. In the present study, MnO/hollow nanobox metal-organic framework (HNM)-AuPtPd nanocomposites were prepared via multi-step synthesis and superposition method and a series of characterizations were carried out. A highly sensitive immunosensor Ab/MnO/HNM-AuPtPd/GCE based on the composite nanomaterial was further prepared and used to detect the tumor marker CA72-4.

FF-STGCN: A usage pattern similarity based dual-network for bike-sharing demand prediction.

Accurate bike-sharing demand prediction is crucial for bike allocation rebalancing and station planning. In bike-sharing systems, the bike borrowing and returning behavior exhibit strong spatio-temporal characteristics. Meanwhile, the bike-sharing demand is affected by the arbitrariness of user behavior, which makes the distribution of bikes unbalanced.

Assessing the determinants of corporate environmental investment: a machine learning approach.

In recent years, experts and academics in the environmental management field have developed an interest in the factors and evaluation techniques that influence corporate environmental investment decisions. However, there are substantial differences between studies employing the most recent evaluation methodologies and those that use indicator systems. To explore the mechanisms that influence corporate environmental investment, this study investigated the determinants of environmental investment through the perspectives of firm, board, chair, and chief executive officer (CEO) characteristics using a machine learning approach.

Pillar-Layered Porous Metal-Organic Frameworks with CoNO Clusters and Tetragonal Ligands for CO Conversion.

Converting CO to valuable chemicals and fuels is a viable method to establish a carbon-neutral energy cycle in the environment. Metal-organic frameworks (MOFs), characterized by dispersed active sites, high porosity, etc., have displayed a great application prospect in the electrochemical/chemical CO reduction reaction (CORR) process.

Stable Co(II)-based coordination polymer as fluorescence sensor for the discriminative sensing of biomarker methylmalonic acid.

Three novel Co-based coordination polymers including {[Co(L)(μ-O)]} (1), {[Co(L)(bimb)]} (2) and {[Co(L)(bimmb)]} (3) (HL = 2,6-di(4-carboxylphenyl)-4-(4-(triazol-1-ylphenyl))pyridine), bimb = 1,4-bis(lmidazol) butane, bimmb = 1,4-bis(imidazole-1-ylmethyl)benzene) were successfully prepared under solvothermal conditions and characterized. Single-crystal X-ray diffraction analyses revealed that 1 possesses a 3D architecture composed of a trinuclear cluster [CoN(CO)(μ-O)], 2 exhibits a 2D new topological framework with the point symbol (8·12)(8), whereas 3 shows a unique six-fold interpenetrated 3D framework with a (6·8·10)(6)(8) topology. Impressively, all of them can function as a highly selective and sensitive fluorescent sensor for the biomarker methylmalonic acid (MMA) via fluorescence quenching.

Gender Congruency Effects in Spanish: Behavioral Evidence from Noun Phrase Production.

Grammatical gender as a lexico-syntactic feature has been well explored, and the gender congruency effect has been observed in many languages (e.g., Dutch, German, Croatian, Czech, etc.

Designed Construction of 2D Honeycomb Cationic MOF Materials for Selective Removal of Sulfonic Anionic Dyes.

Various carcinogenic dyes in water bodies are difficult to degrade due to their stability to light and oxidants, causing extended pollution. In this study, MOF ({[Co(tib)]·(HO)·SO}) and MOF ({[Cu(tib)]·(HO)·SO}) (tib = 1,3,5-tirs(1-imidazolyl)benzene) were synthesized by the solvothermal method. MOFs and were successfully characterized by single-crystal X-ray diffraction (XRD) and powder X-ray diffraction (PXRD).

Three-Dimensional Cadmium-Organic Framework with Dual Functions of Oxygen Evolution in Water Splitting and Fenton-like Photocatalytic Removal of Organic Pollutants.

Metal-organic frameworks (MOFs) have exhibited appreciable potential as catalytic agents in the field of material science. The research of new MOFs with dual functions in electrocatalysis and photocatalysis under ultraviolet (UV) irradiation is extremely pivotal for renewable energy applications. Hence, we synthesized a series of three-dimensional MOFs, namely, [Cd(bimb)(HITA)] (-), {[Cd(bimb)](NO)} (-), and [Cd(bimb)(ONO)] (-) (bimb = 1,4-bis(imidazol-1-ylmethyl)benzene; HITA = 5-hydroxyisophthalic acid), with applicability in the oxygen evolution reaction process and Fenton-like photocatalysis.

Exploration of the Main Antibiofilm Substance of ATCC 14917 and Its Effect against .

Dental plaque, a complex biofilm system established by cariogenic bacteria such as (), is the initiator of dental caries. Studies have found that the cell-free supernatant (CFS) of could inhibit biofilm formation. However, the main antibiofilm substance of the CFS that acts against is unclear.

Streptococcus mutans membrane vesicles inhibit the biofilm formation of Streptococcus gordonii and Streptococcus sanguinis.

Streptococcus mutans, whose main virulence factor is glucosyltransferase (Gtf), has a substantial impact on the development of dental caries. S. mutans membrane vesicles (MVs), which are rich in Gtfs, have been shown to affect biofilm formation of other microorganisms.

Membrane Vesicles Enhance Pathogenicity and Carbohydrate Metabolism.

and , as the most common bacterium and fungus in the oral cavity respectively, are considered microbiological risk markers of early childhood caries. membrane vesicles (MVs) contain virulence proteins, which play roles in biofilm formation and disease progression. Our previous research found that MVs harboring glucosyltransferases augment biofilm formation by increasing exopolysaccharide production, but the specific impact of MVs on virulence and pathogenicity is still unknown.

Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp C-H Functionalization.

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl ()-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine.

Cascade Wolff Rearrangement/Acylation: A Metal-Free and Eco-Friendly Approach for 4-Hydroxy-pyrazolo[3,4-]pyridin-6-ones and -Pyrazole Amides Synthesis from 5-Aminopyrazoles and α-Diazoketones.

A highly chemoselective cascade Wolff rearrangement/acylation reaction between 5-aminopyrazoles and diazo compounds has been developed. The protocol can facilitate the switchable synthesis of 4-hydroxy-pyrazolo[3,4-]pyridin-6-ones and -pyrazole amides with the merits of a broad substrate scope, high functional group compatibility, and green and sustainable performance manner. All reactions proceeded efficiently without any catalyst and additives (acid and base) and resulted in the release of benign N, wherein diethyl carbonate served as a green benign solvent.

One-Pot Synthesis of Chromone-Fused Pyrrolo[2,1-]isoquinolines and Indolizino[8,7-]indoles: Iodine-Promoted Oxidative [2 + 2 + 1] Annulation of -Acetylphenoxyacrylates with Tetrahydroisoquinolines and Noreleagnines.

An iodine-promoted one-pot cascade oxidative annulation reaction has been developed for the synthesis of chromone-fused-pyrrolo[2,1-]isoquinolines and indolizino[8,7-]indoles from -acetylphenoxyacrylates, tetrahydroisoquinolines, and noreleagnines. This process underwent a logical approach to both chromone-fused-pyrrolo[2,1-]isoquinolines and chromone-fused-indolizino[8,7-]indoles isolamellarin derivatives. Manipulations of l-menthol and dl-α-tocopherol demonstrate the applications of this strategy.