Rational Regulation of High-Entropy Perovskite Oxides through Hole Doping for Efficient Oxygen Electrocatalysis.

Due to the high configuration entropy, unique atomic arrangement, and electronic structures, high-entropy materials are being actively pursued as bifunctional catalysts for both the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in rechargeable zinc-air batteries (ZABs). However, a relevant strategy to enhance the catalytic activity of high-entropy materials is still lacking. Herein, a hole doping strategy has been employed to enable the high-entropy perovskite La(CrMnFeCoNi)O to effectively catalyze the ORR and OER.

Tuning the high-entropy perovskite as efficient and reliable electrocatalysts for oxygen evolution reaction.

Due to their unique electronic structure, atomic arrangement and synergistic effect, high-entropy materials are being actively pursued as electrocatalysts for oxygen evolution reaction (OER) in water splitting. However, a relevant strategy to improve high-entropy materials is still lacking. Herein, substitutional doping on the La-site in high-entropy perovskite La Sr (CrMnFeCoNi)O is reported as an efficient OER catalyst.

Application Analysis of Low-Pressure Perfusion Combined with Occluder in Holmium Laser Lithotripsy for Patients with Middle and Upper Ureteral Calculi.

Background: Ureteroscopic holmium laser lithotripsy has become one of the main methods of treating ureteral calculi. However, in the treatment of middle and upper ureteral calculi, ureteroscopy is difficult to operate owing to the high location of calculi. Thus, how to improve the treatment effect and reduce the stone migration has become the focus in clinical settings.

Engineering Iron-Based Nanomaterials for Breast Cancer Therapy Associated with Ferroptosis.

Ferroptosis has received increasing attention as a novel nonapoptotic programmed death. Recently, iron-based nanomaterials have been extensively exploited for efficient tumor ferroptosis therapy, as they directly release high concentrations of iron and increase intracellular reactive oxygen species levels. Breast cancer is one of the commonest malignant tumors in women; inhibiting breast cancer cell proliferation through activating the ferroptosis pathway could be a potential new target for patient treatment.

P-Incorporation Induced Enhancement of Lattice Oxygen Participation in Double Perovskite Oxides to Boost Water Oxidation.

Activating the lattice oxygen in the catalysts to participate in the oxygen evolution reaction (OER), which can break the scaling relation-induced overpotential limitation (> 0.37 V) of the adsorbate evolution mechanism, has emerged as a new and highly effective guide to accelerate the OER. However, how to increase the lattice oxygen participation of catalysts during OER remains a major challenge.

A valuable subarachnoid space named the occipito-atlantal cistern.

The cisterna magna has been defined as the space between the inferior margin of the cerebellar vermis to the level of the foramen magnum, while an enlarged dorsal subarachnoid space at the occipito-cervical junction extending from the foramen magnum to the upper border of the axis (C2) is still ignored. Recently, the myodural bridge complex is proved to drive the cerebral spinal fluid flowing via this region, we therefore introduce the "occipito-atlantal cistern (OAC)" to better describe the subarachnoid space and provide a detailed rationale. The present study utilized several methods, including MRI, gross anatomical dissection, P45 sheet plastination, and three-dimensional visualization.

Neuromuscular electrical stimulation effect on mRNA expression of skeletal muscle in elderly.

Considering the increasing number of elderly in the world, this research aimed to investigate the effect of neuromuscular electrical stimulation (NMES) on changes in muscle mRNA abundance of a number of gene targets for improving the balance of the elderly. Twenty-six elderly undertook 30 minutes of quadriceps NMES (50 Hz, current at the limit of tolerance). Vastus lateralis muscle biopsies were obtained at rest immediately before and 24 hours after the intervention.

Application of nanomaterials in the treatment of intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by the rupture of blood vessels in the brain parenchyma, with an acute mortality rate of 30%‒40%. Currently, available treatment options that include surgery are not promising, and new approaches are urgently needed. Nanotechnology offers new prospects in ICH because of its unique benefits.

The Important Role of Zinc in Neurological Diseases.

Zinc is one of the most abundant metal ions in the central nervous system (CNS), where it plays a crucial role in both physiological and pathological brain functions. Zinc promotes antioxidant effects, neurogenesis, and immune system responses. From neonatal brain development to the preservation and control of adult brain function, zinc is a vital homeostatic component of the CNS.

Acid-triggered aggregation of Janus nanoparticles for enhanced imaging-guided photothermal therapy.

Poor tumor delivery efficiency remains a significant challenge for the integrated nanoplatform for diagnosis and treatment. Nanotherapeutics capable of aggregation in response to the tumor microenvironment has received considerable attention because of its ability to enhance tumor delivery efficiency and accumulation. We prepared smart Au-FeO Janus nanoparticles (GIJ NPs) modified with mixed-charged ligands (3,4-dihydroxyhydrocinnamic acid [DHCA] and trimethylammonium dopamine [TMAD]).

Therapeutic strategies for intracerebral hemorrhage.

Stroke is the second highest cause of death globally, with an increasing incidence in developing countries. Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes. ICH is associated with poor neurological outcomes and high mortality due to the combination of primary and secondary injury.

RNA-seq reveals transcriptional differences in anthocyanin and vitamin biosynthetic pathways between black and white rice.

Anthocyanins and vitamins in black rice are the micronutrients vital to human health, both of which predominantly accumulate in the bran fraction. Some studies have demonstrated that black rice contains more vitamins compared with common white rice, indicating potential association between anthocyanin and vitamin accumulation. In this study, transcriptomes of pericarps collected from 27 black rice accessions and 49 white rice accessions at 10 days after flowering (DAF) were sequenced and analyzed.

Multiple organelle-targeted near-infrared fluorescent probes toward pH and viscosity.

Organelles, including mitochondria (mito), lysosomes (lyso), endoplasmic reticulum (ER), Golgi apparatus (Golgi), and ribosome et al., play a vital role in maintaining the regular work of the cell. Viscosity is an essential parameter in the cellular microenvironment.

Effect of Electrical Stimulation Followed by Exercises in Postnatal Diastasis Recti Abdominis via MMP2 Gene Expression.

Since abdominal muscle training is one of the most important ways to treat rectal diastasis, it is necessary to design and provide appropriate exercises to treat this problem. One of the complementary methods to achieve higher intensity training is the use of electrical muscle stimulation along with voluntary activity, which causes maximum recall in muscle units. Therefore, in the current study, the effect of electrical stimulation followed by exercises was evaluated in postnatal diastasis recti abdominis via MMP2 gene expression.

Neuroprotection by Ozanimod Following Intracerebral Hemorrhage in Mice.

The destruction of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) is associated with poor prognosis. Modulation of sphingosine 1-phosphate receptor (S1PR) may improve outcomes from ICH. Ozanimod (RPC-1063) is a newly developed S1PR regulator which can selectively modulate type 1/5 sphingosine receptors.

Iron Neurotoxicity and Protection by Deferoxamine in Intracerebral Hemorrhage.

Intracerebral hemorrhage (ICH) is a subtype of stroke that is characterized by high morbidity and mortality, for which clinical outcome remains poor. An extensive literature indicates that the release of ferrous iron from ruptured erythrocytes in the hematoma is a key pathogenic factor in ICH-induced brain injury. Deferoxamine is an FDA-approved iron chelator that has the capacity to penetrate the blood-brain barrier after systemic administration and binds to iron.

Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging.

Iron oxide nanoparticle (IONP) with unique magnetic property and high biocompatibility have been widely used as magnetic resonance imaging (MRI) contrast agent (CA) for long time. However, a review which comprehensively summarizes the recent development of IONP as traditional CA and its new application for different modality of MRI, such as imaging, simultaneous / or MRI/other imaging modality, and as environment responsive CA is rare. This review starts with an investigation of direction on the development of high-performance MRI CA in both and modal based on quantum mechanical outer sphere and Solomon-Bloembergen-Morgan (SBM) theory.

Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive -Weighted Contrast-Enhanced Brain Imaging.

Manganese oxide nanoparticles (NPs) have attracted increasing attention recently as contrast agents (CAs) for magnetic resonance imaging (MRI). However, the clinical translation and popularization of conventional MnO NPs are hampered by their relatively poor imaging performance. Herein, we report the construction of ultrasmall MnO NPs (USMnO) a one-pot synthetic approach that show a much better capability of -weighted contrast enhancement for MRI ( = 15.

Arsenite-loaded albumin nanoparticles for targeted synergistic chemo-photothermal therapy of HCC.

Arsenic trioxide (ATO, AsO), an active ingredient of traditional Chinese medicine, has been approved by the U.S. Food and Drug Administration as an effective therapeutic agent for acute promyelocytic leukemia (APL).

Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice.

Intracerebral hemorrhage (ICH) is a severe neurological dysfunction and a medical emergency with a high mortality rate. Minocycline ameliorates deficits in rodent models of acute and chronic neurological diseases. However, the role of minocycline in ICH remains unclear.

The combination of deferoxamine and minocycline strengthens neuroprotective effect on acute intracerebral hemorrhage in rats.

: Intracerebral hemorrhage (ICH) is a devastating type of strokes that carries high mortality rates, but effective therapeutic options are still lacking. Here, the adult rat model of ICH was used to investigate the efficacy of a combinational therapy of deferoxamine (DFX) and minocycline.: The ICH was induced by stereotaxic infusion of collagenase into striatum of adult rats.

Hollow iron oxide nanomaterials: synthesis, functionalization, and biomedical applications.

Hollow iron oxide nanoparticles (NPs) are an attractive class of hollow nanostructures that have received significant attention in the biomedical field due to their low toxicity, good biocompatibility, and intrinsic magnetic nature. We review the recent advances in the preparation, surface functionalization, and biomedical applications of hollow iron oxide NPs. Hollow iron oxide NPs are generally synthesized by the following five strategies, including the Kirkendall effect, galvanic replacement, chemical etching, nano template-mediated, and hydrothermal/solvothermal routes.