Publications by authors named "Ruixing Hu"
The formin protein Diaph3 is an actin nucleator that regulates numerous cytoskeleton-dependent cellular processes through the activation of actin polymerization. Expression and activity of Diaph3 is tightly regulated: lack of Diaph3 results in developmental defects and embryonic lethality in mice, while overexpression of Diaph3 causes auditory neuropathy. It is known that Diaph3 homophilic interactions include the intramolecular interaction of its Dia-inhibitory domain (DID)-diaphanous autoregulatory domain (DAD) domains and the intermolecular interactions of DD-DD domains or FH2-FH2 domains.
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- The study focuses on the genomic structure of crab-eating and rhesus macaques, addressing the need for better understanding of their genetic differences and similarities.
- Researchers provide a complete genome assembly for the crab-eating macaque and 20 haplotype-resolved assemblies to explore significant genomic variations between the two species and their implications.
- Findings include that macaques have lower segmental duplication and longer centromeres than humans, as well as differences in genetic variants and alternative splicing, which may relate to metabolic and evolutionary traits, enhancing their use in biomedical research.
TRAF7 serves as a crucial intracellular adaptor and E3 ubiquitin ligase involved in signal transduction pathways, contributing to immune responses, tumor progression, and embryonic development. Somatic mutations within the coiled-coil (CC) domain and WD40 repeat domain of TRAF7 could cause brain tumors, while germline pathogenic mutations contribute to severe developmental abnormalities. However, the precise molecular mechanism underlying TRAF7 involvement in embryonic development remains unclear.
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