Autoimmune diseases (AID) have emerged as prominent contributors to disability and mortality worldwide, characterized by intricate pathogenic mechanisms involving genetic, environmental, and autoimmune factors. In response to this challenge, a growing body of research in recent years has delved into genetic modifications, yielding valuable insights into AID prevention and treatment. Sirtuins (SIRTs) constitute a class of NAD-dependent histone deacetylases that orchestrate deacetylation processes, wielding significant regulatory influence over cellular metabolism, oxidative stress, immune response, apoptosis, and aging through epigenetic modifications.
View Article and Find Full Text PDFBackground: Epididymal leiomyosarcoma is an extremely rare tumor. In this study, we describe the sonographic features of this uncommon tumor.
Methods: A case of epididymal leiomyosarcoma diagnosed at our institute was retrospectively analyzed.
The distal radial artery (DRA) approach has emerged as a new approach in cardiovascular intervention. In recent years, ultrasound has been widely used in cardiovascular intervention the DRA approach. This article systematically discusses the progress of ultrasound in the preoperative vascular assessment, intraoperative guided puncture and postoperative observation of complications the DRA approach.
View Article and Find Full Text PDFBackground: This study investigated the safety and efficacy of coronary angiography (CAG) and percutaneous coronary intervention (PCI) via distal transradial artery access (d-TRA).
Methods: For this single-centre prospective cohort study, a total of 1066 patients who underwent CAG or PCI procedures from September 2019 to November 2020 were included. Patients were divided into two groups: the d-TRA group (346) and the conventional transradial artery access (c-TRA) group (720) based on access site.
Our purpose of this study was to present simulation and experimental studies on magnetic hyperthermia (MH) with use of an alternating magnetic field (AMF) and superparamagnetic iron oxide nanoparticles (Resovist®). In the simulation studies, the energy dissipation (P) and temperature rise rate (∆T/∆t) were computed under various conditions by use of the probability density function of the particle size distribution based on a log-normal distribution. P and ∆T/∆t and their dependence on the frequency of the AMF (f) largely depended on the particle size of Resovist®.
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