Roles of TRPM channels in glioma.

Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy.

Identifying influential nodes based on the disassortativity and community structure of complex network.

The complex networks exhibit significant heterogeneity in node connections, resulting in a few nodes playing critical roles in various scenarios, including decision-making, disease control, and population immunity. Therefore, accurately identifying these influential nodes that play crucial roles in networks is very important. Many methods have been proposed in different fields to solve this issue.

Super-enhancers complexes zoom in transcription in cancer.

Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by altering protein-coding gene expression and noncoding regulatory element function. Therefore, they play central roles in the treatment of cancer.

PIWI-interacting RNAs: Critical roles and therapeutic targets in cancer.

P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a novel class of small regulatory RNAs (approximately 24-31 nucleotides in length) that often bind to members of the PIWI protein family. piRNAs regulate transposons in animal germ cells; piRNAs are also specifically expressed in many human tissues and regulate pivotal signaling pathways. Additionally, the abnormal expression of piRNAs and PIWI proteins has been associated with various malignant tumours, and multiple mechanisms of piRNA-mediated target gene dysregulation are involved in tumourigenesis and progression, suggesting that they have the potential to serve as new biomarkers and therapeutic targets for tumours.

Structures and paramagnetism of five heterometallic pentanuclear metal strings containing as many as four different metals: NiPtCoPd(tpda)Cl.

Five heterometallic pentanuclear metal strings were prepared by stepwise synthesis from two to three and four kinds of metals aligned in one chain. In particular, NiPtCo2Pd(tpda)4Cl2 (5) possesses four different metals, and the SQUID measurement shows that Ni2+ is the only magnetically active center. Besides, the shortest Co(ii)-Co(ii) single bond (2.

[Surface-enhanced raman spectroscopic analysis of largehead Atractylodes rhizome decoction].

The normal Raman spectra and surface-enhanced Raman spectra (SERS) of largehead atractylodes rhizome decoction were tested and analyzed. The characteristic Raman bands of largehead atractylodes rhizome decoction were tentatively assigned. Six obvious Raman bands (396, 548, 617, 730, 955 and 1327 cm(-1)) were observed in the SERS of largehead atractylodes rhizome decoction.

Interpenetrating polymer networks as a route to tunable multi-responsive biomaterials: development of novel concepts.

Novel concepts are proposed for interpenetrating polymer networks (IPNs) that can be used in biomaterials responsive to multiple types of environmental stimuli. The IPNs can be a route to the tunable biomaterials whose chemical structure and/or morphology can be adjusted to the type of task to be performed. The significance of utilizing new types of processes in polymer chemistry such as the Suzuki polycondensation and living/controlled radical polymerizations to the possibility of extending/modifying component networks in the IPNs and fine-tuning their properties is emphasized.

Biocompatible poly(N-vinyllactam)-based materials with environmentally-responsive permeability.

Biocompatible polymer-based materials whose properties respond to environmental stimuli are of great value in biomedical and biotechnological applications (e.g., controlled release of drugs and sensitive reactants, bioseparations, spontaneous adjusting of flow of liquids including flow control in microfluidic devices).