Publications by authors named "Ruixian Tian"
Article Synopsis
- Hypoxia, or low oxygen levels, can affect the muscles in the uterus during pregnancy and delivery.
- This study looked at how a process called autophagy, which helps cells recycle and manage their resources, changes when there's low oxygen in special uterine cells from pregnant mice.
- The researchers found that low oxygen increases autophagy but makes these muscle cells grow less, and using certain chemical tools can either boost or block this effect.
Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
Am J Physiol Cell Physiol
April 2024
Intrauterine infection during pregnancy can enhance uterine contractions. A two-pore K channel TREK1 is crucial for maintaining uterine quiescence and reducing contractility, with its properties regulated by pH changes in cell microenvironment. Meanwhile, the sodium hydrogen exchanger 1 (NHE1) plays a pivotal role in modulating cellular pH homeostasis, and its activation increases smooth muscle tension.
View Article and Find Full Text PDFGestational diabetes mellitus (GDM) is a common pregnancy complication strongly associated with poor maternal-fetal outcomes. Its incidence and prevalence have been increasing in recent years. Women with GDM typically give birth through either vaginal delivery or cesarean section, and the maternal-fetal outcomes are related to several factors such as cervical level, fetal lung maturity, the level of glycemic control still present, and the mode of treatment for the condition.
View Article and Find Full Text PDF