Publications by authors named "Ruixia Ju"
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an epigenetic regulator that plays critical roles in tumours. However, the DNA methylation alteration patterns driven by UHRF1 and the related differentially expressed tumour-related genes remain unclear. In this study, a UHRF1-shRNA MCF-7 cell line was constructed, and whole-genome bisulfite sequencing and RNA sequencing were performed.
View Article and Find Full Text PDFArticle Synopsis
- FOXM1 is a transcription factor linked to cell growth and tumor development, and its high levels are associated with poor cancer prognosis; however, the reasons behind its overexpression are not well understood.
- The study reveals that ABL1, a nonreceptor tyrosine kinase, enhances FOXM1 expression by binding to it and phosphorylating specific tyrosine residues, particularly pY575, which is crucial for stabilizing FOXM1 and preventing its degradation.
- The research demonstrates that FOXM1 with the pY575 mutation is less stable and leads to slower cell division and reduced tumor growth, suggesting that targeting ABL1 may be a potential treatment strategy for cancers