Digital image steganalysis network strengthening framework based on evolutionary algorithm.

To solve the problem of increasing network parameters and increasing fitting fluctuation during training due to the improvement or expansion of image steganalysis network, a framework for strengthening steganalysis network was considered. The principle of searching space optimization by evolutionary algorithm was used to guide the adjustment of parameter direction during network training. Firstly, the diversity of the steganalysis network is initialized based on the rules of the evolutionary algorithm, and the coding mapping is carried out according to the network structure to achieve the purpose of unifying the subsequent network strengthening objects.

Drug repositioning of COVID-19 based on mixed graph network and ion channel.

Research on the relationship between drugs and targets is the key to precision medicine. Ion channel is a kind of important drug targets. Aiming at the urgent needs of corona virus disease 2019 (COVID-19) treatment and drug development, this paper designed a mixed graph network model to predict the affinity between ion channel targets of COVID-19 and drugs.

Efficacy and safety of Abelmoschus manihot in treating chronic kidney diseases: A multicentre, open-label and single-arm clinical trial.

Rationale And Objective: The efficacy of Abelmoschus manihot (AM) in treating of chronic kidney disease (CKD) has been confirmed by prior trials. AM is also commonly combined to other medicines among CKD patients in clinic. This trial aimed at evaluating the safety of AM combination application, and further verifying the efficacy of AM in treating various types of CKD.

Role of solution chemistry in the attachment of graphene oxide nanoparticles onto iron oxide minerals with different characteristics.

Given the ubiquity and abundance of the iron oxide minerals and their important roles in affecting the environmental fate of graphene oxide (GO) nanoparticles, the attachment of GO onto three iron oxide minerals (i.e., hematite, goethite, and ferrihydrite) under different solution chemistry conditions was investigated in this study.

Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats.

Mitochondrial dysfunction is involved in the pathogenesis of chronic kidney disease (CKD). Resveratrol has been demonstrated to be beneficial for the recovery of kidney diseases. In this study, the 5/6 nephrectomized rat was used as a CKD model and the TGF-β1-exposed mouse mesangial cells were used as an in vitro model.

Probucol inhibits JAK2-STAT pathway activation and protects human glomerular mesangial cells from tert-butyl hydroperoxide induced premature senescence.

Human mesangial cells (HMCs) have a finite lifespan and eventually enter irreversible growth arrest known as cellular senescence, which is thought to contribute to kidney ageing and age-related kidney disorders such as chronic kidney disease. The JAK2-STAT pathway plays a pivotal role in transmitting cytokine signals, including cell proliferation, apoptosis, and differentiation, but whether it could regulate HMC senescence still remains to be explored. In our study, tert-butyl hydroperoxide (tBHP)-induced cells accelerated HMC senescence, as judged by increased senescence-associated β-galactosidase stained positive cells, morphological changes, and G0-G1 cell cycle arrest.