Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm.

Pasteurella multocida is an important zoonotic respiratory pathogen capable of infecting a diverse range of hosts, including humans, farm animals, and wild animals. However, the precise mechanisms by which P. multocida compromises the pulmonary integrity of mammals and subsequently induces systemic infection remain largely unexplored.

Secretome Analysis of High- and Low-Virulent Bovine Cultured in Different Media.

Bovine () serotype A is one of the major causes of bovine respiratory disease (BRD). We used data-independent acquisition (DIA) LC-MS/MS combined with bioinformatics analysis to identify proteins secreted by . A total of 154 proteins were obtained from the supernatants of two isolates of bovine serotype A (high virulent PmCQ2 and low virulent PmCQ6) cultured in Martin or BHI media, of which 50 were identified as putative secreted proteins.

Emergence and genomic analysis of a novel sublineage of bovine ephemeral fever virus in Southwest China.

Introduction: Bovine ephemeral fever virus (BEFV), belonging to the genus under the family , is the etiological cause for the bovine ephemeral fever (BEF) in cattle and water buffalo.

Methods: In this study, we report recent BEF outbreaks in Southwest China and sequence the complete genome sequence of one BEFV isolate BEFV/CQ1/2022.

Results And Discussion: Comparative genomic analyses between BEFV/CQ1/2022 and isolates available in GenBank revealed remarkable inter-isolate divergence.