[Preliminary Study of the Role of INPP4B in Promoting Colorectal Cancer Metastasis and the Mechanisms Involved].

Objective: To investigate the expression of inositol polyphosphate 4-phosphatase type Ⅱ B (INPP4B) in colorectal cancer (CRC) and the relevant clinical significance, to determine the relationship between INPP4B and matrix metallopeptidase 7 (MMP7) in CRC cells, and to make preliminary exploration of the effects of INPP4B on the proliferation and migration of CRC cells and mechanisms involved.

Methods: The TIMER2.0 and GEPIA2 databases were used to analyze the differences in expression between cancer and para-cancerous tissues and the effects of such differences on the prognosis of CRC.

SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3.

Research demonstrated that folate deficiency in either the mother or father could impact the biological functions of the offspring's of neural cells. Folate deficiency can also impair the methionine cycle, thus contributing to the conversion of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH), which could potentially cause damage to the central nervous system. The study focused on the effect of parental folate deficiency on neural cell apoptosis in offspring neonatal rats and whether it is mediated by the levels of SAM and SAH in brains.

Screening Heteroatom Configurations for Reversible Sloping Capacity Promises High-Power Na-Ion Batteries.

Heteroatom doping has been proved to effectively enhance the sloping capacity, nevertheless, the high sloping capacity almost encounters a conflict with the disappointing initial Coulombic efficiency (ICE). Herein, we propose a heteroatom configuration screening strategy by introducing a secondary carbonization process for the phosphate-treated carbons to remove the irreversible heteroatom configurations but with the reversible ones and free radicals remaining, achieving a simultaneity between the high sloping capacity and ICE (≈250 mAh g and 80 %). The Na storage mechanism was also studied based on this "slope-dominated" carbon to reveal the reason for the absence of the plateau.

Synergistic oxygen reduction of dual redox catalysts boosting the power of lithium-air battery.

The development of rechargeable Li-air batteries has been confronted by the critical challenges of large overpotential loss, low achievable capacity, and prohibitively poor cycling and power performance. Surface passivation and pore clogging of the cathode due to the formation of Li2O2 during discharge result in sluggish interfacial charge transfer and have an impact on the mass transport of Li+ ions and O2 in the electrode, consequently giving rise to large voltage hysteresis and premature termination of discharge with low power performance. Here we report a redox flow lithium-oxygen cell with a modified redox electrolyte to tackle these issues.

Redox-Targeting-Based Flow Batteries for Large-Scale Energy Storage.

Redox-targeting reactions of battery materials by redox molecules are extensively studied for energy storage since the first report in 2006. Implementation of the "redox-targeting" concept in redox flow batteries presents not only an innovative idea of battery design that considerably boosts the energy density of flow-battery system, but also an intriguing research platform applied to a wide variety of chemistries for different applications. Here, a critical overview of the recent progress in redox-targeting-based flow batteries is presented and the development of the technology in the various aspects from mechanistic understanding of the reaction kinetics to system optimization is highlighted.

Determining Li-Coupled Redox Targeting Reaction Kinetics of Battery Materials with Scanning Electrochemical Microscopy.

The redox targeting reaction of Li-storage materials with redox mediators is the key process in redox flow lithium batteries, a promising technology for next-generation large-scale energy storage. The kinetics of the Li-coupled heterogeneous charge transfer between the energy storage material and redox mediator dictates the performance of the device, while as a new type of charge transfer process it has been rarely studied. Here, scanning electrochemical microscopy (SECM) was employed for the first time to determine the interfacial charge transfer kinetics of LiFePO/FePO upon delithiation and lithiation by a pair of redox shuttle molecules FcBr and Fc.