Combination therapy using Cel-CSO/Taxol NPs for reversing drug resistance in breast cancer through inhibiting PI3K/AKT/NF-κB/HIF-1α pathway.

The resistance of malignant tumors to multiple drugs is a significant obstacle in cancer treatment and prognosis. Accordingly, we synthesized a celastrol (Cel) prodrug (Cel-CSO) by conjugating chitosan oligosaccharides (CSO) to Cel for reversing Taxol resistance in chemotherapy, followed by self-assembly with Taxol into a novel nanoplatform of Cel-CSO/Taxol nanoparticles (termed NPs). NPs showed a suitable size (about 153 nm), excellent stability and prolonged release of Cel and Taxol in a manner that depended on both pH and time.

Dynamic Modeling and Performance Analysis of a Hip Rehabilitation Robot.

The dynamic performance of a 2-DOF hip joint rehabilitation robot configuration for patients with hip joint dyskinesia was analyzed. There were eight revolute pairs on one side of the hip joint rehabilitation robot configuration. The dynamics of the robot configuration were analyzed with the Newton-Euler method, and a dynamic model was developed.

Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery.

The security and efficiency of gene delivery vectors are inseparable for the successful construction of a gene delivery vector. This work provides a practical method to construct a charge-regulated, hydrophobic-modified, and functionally modified polyethylenimine (PEI) with effective gene delivery and perfect transfection performance through a condensation reaction, named BA-PEI. The carrier was shown to possess a favorable compaction of miRNAs into positively charged nanoparticles with a hydrodynamic size of approximately 100 nm.

Age and gender differences in static and dynamic balance of Chinese preschool children.

Balance is a crucial ability of early age, but there is conflicting evidence with regard to age and gender differences in preschool children's balance ability. Additionally, there are several tools available to measure balance, yet, wide variation in their use has restricted the capacity to synthesize the reference values. Therefore, the primary purpose of this study was to investigate the balance ability of preschool-aged children and determine how it is moderated by age and gender.

Sc/C codoping effect on the electronic and optical properties of the TiO (101) surface: a first-principles study.

Extension of the light absorption range and a reduction of the possibility of the photo-generated electron-hole pair recombination are the main tasks to break the bottleneck of the photocatalytic application of TiO. In this paper, we systematically investigate the electronic and optical properties of Sc-doped, C-doped, and Sc/C-codoped TiO (101) surfaces using spin-polarized DFT+U calculations. The absorption coefficient of the Sc/C-codoped TiO (101) surfaces were enhanced the most compared with the other two doped systems in the high energy region of visible light, which can be attributed to the shallow impurity states.

Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer.

Celastrol is a promising antitumor drug candidate, but the poor water solubility and cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan oligosaccharide (CSO) conjugate (Cel-CSO) for drug delivery. Celastrol was conjugated to a CSO backbone via amide bond formation, which was verified by infrared spectrum (IR) analyses.

Significantly Enhanced Thermal Decomposition of Mechanically Activated Ammonium Perchlorate Coupling with Nano Copper Chromite.

In this article, nano-CuCrO (copper chromite)/ultrafine ammonium perchlorate (AP) composites were prepared by a ultrasonic dispersion method and a mechanical grinding method. A series of nano-CuCrO/ultrafine AP composites with different dispersions were prepared by controlling the compounding time to study the best catalytic effect of nano-CuCrO on the ultrafine AP. The microstructures, surface elements, and morphologies of samples were analyzed by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and energy dispersion X-ray spectroscopy.

Simulation study on the mining conditions of dissolution of low grade solid potash ore in Qarhan Salt Lake.

The output and grade of liquid potash minerals in Qarhan Salt Lake are decreasing year by year, which has become the main problem restricting the sustainable production of potassium fertilizer. The exploitation and utilization of low-grade solid potash ore, which is in the strata of the Qarhan Salt Lake, represents the fundamental framework for the sustainable development of Qarhan Salt Lake's potash fertilizer. PHREEQC is a simulation software for hydrogeochemistry.

antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration.

The purpose of this study is to evaluate antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC). The CCTP conjugate contained 4∼ wt % TP and displayed excellent aqueous solubility (5 mg/mL) as compared to the native TP (17 μg/mL). cytotoxicity of CCTP conjugate was evaluated by CCK8 assay against human pancreatic cancer (PC) cell lines, showing comparable the half maximal inhibitory concentration (IC) values to the parent TP.

Pyruvate kinase M2 is a marker of poor prognosis in lung adenocarcinoma but not lung squamous cell carcinoma.

Background: To explore the pyruvate kinase M2 (PKM2) expression profile as a prognostic marker of lung adenocarcinoma (LUAD) as well as lung squamous cell carcinoma (LUSC).

Methods: Retrospective bioinformatics analysis of data from the Cancer Genome Atlas-Lung Cancer dataset and the Human Protein Atlas was performed. PKM2 mRNA expression was monitored using the Kaplan-Meier Plotter online database.

Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs.

Purpose: High myopia can lead to blindness. Genipin is a collagen cross-linking agent that may be used to treat myopia. However, the mechanism of action of genipin for the treatment of myopia is unclear.

Effects of the long wavelength-filtered continuous spectrum on natural refractive development in juvenile guinea pigs.

Aim: To investigate the effects of spectral composition and light intensity on natural refractive development in guinea pigs.

Methods: A total of 124 pigmented guinea pigs (2-week-old) were randomly assigned to three groups at high (Hi; 4000 lx), medium (Me; 400 lx) and low (Lo; 50 lx) light intensities under a 12:12 light/dark cycle for 6wk. Each group was subdivided into subgroups with the following spectra: broad spectrum Solux halogen light (BS), 600 nm above-filtered continuous spectrum (600F), 530 nm above-filtered continuous spectrum (530F), and 480 nm above-filtered continuous spectrum (480F; HiBS: =10, Hi600F: =10, Hi530F: =10, Hi480F: =10, MeBS: =10, Me600F: =10, Me530F: =10, Me480F: =10, LoBS: =11, Lo600F: =12, Lo530F: =10, Lo480F: =11).

Theoretical studies on the electronic structures and optical properties of (Cu, C)-codoped rutile TiO from GGA+U calculations.

The electronic structures, formation energy and optical properties of Cu-doped, C-doped, and (Cu, C)-codoped TiO were investigated by the projector augmented wave (PAW) method within GGA + U approximation. The results show that the lattice distortion of the Cu@i1&C@i2 system is the largest in all doping systems. The optical absorption edges of the C@i system and the Cu@i1&C@i2 system appear a blue-shift, which is attributed to the band gap expansion and some deep states generation.

[Kinematics and workspace analysis of a spherical exoskeleton parallel mechanism].

Based on the biomechanical simulation curve of OpenSim, an open source software of biomechanical model, a spherical exoskeleton parallel mechanism with two degrees of freedom for hip joint is proposed in this paper for the rehabilitation therapy of patients with impaired leg motor function or elderly people with walking dysfunction. Firstly, the parallel mechanism is modeled and the position inverse solution of the parallel mechanism is obtained using inverse kinematics analysis. The velocity analysis expression of the mechanism is derived by deriving the inverse kinematics solution.

The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis.

Aim: The capability of reducing fibrotic and inflammatory responses in lung tissues represents a gold standard for evaluating the efficacy of therapeutic interventions for treating idiopathic pulmonary fibrosis (IPF). A wide variety of therapeutic strategies have been employed in clinic to treat PF, but limited success has been obtained. Apigenin (4, 5, 7-trihydroxyflavone) is a member of flavonoid family that exerts anti-inflammatory and anti-fibrosis effects.

Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP.

The aim of this study was to examine the role played by substance P and calcitonin gene-related peptide (CGRP) within the dorsal horn of the spinal cord in engagement of antinociception evoked by dexmedetomidine (DEX). Paw withdrawal threshold (PWT) to mechanical stimulation was determined after chronic intrathecal infusion of DEX and enzyme-linked immunosorbent assay (ELISA) was employed to examine the levels of spinal substance P and CGRP. Our results show that PWT was significantly increased by intrathecal administration of DEX in rats ( < 0.

IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection.

In the present study, the aim was to reveal the relationship of serum IL-6, IL-10 and IL-13 levels in patient with Enterovirus 71 (EV71) infection. To elucidate the role of immune mechanisms in the pathogenesis of Hand, foot, and mouth disease (HFMD), we analyzed the cytokine of 112 EV71-infected patients. A significant elevation of serum (interleukin) IL-6, IL-10 and IL-13 levels in patients with EV71 infection compare with Un-EV71 infection HFMD patient and Healthy individuals.

[Preparation and up-conversion luminescence properties of Yb3+/Tm3+ co-doped Sb2O4 powder].

The Sb2O4:Yb3+, Tm3+ up-conversion luminescence powder with excellent physical, chemical stability and relative low phonon energy was synthesized by the high temperature solid-state reaction and its up-conversion luminescence property was investigated. Under the 980 nm excitation, infrared and blue up-conversion emissions centered at 800 and 480 nm were observed, which were assigned to the 1G4-->3H6 and 3H4-->3 He transitions of Tm2+, respectively. The influence of Yb3+ and Tm3+ concentration on the up-conversion emission property was also obtained.

Poly[[diaqua-tris(μ2-4,4'-bi-pyridine)-bis[μ2-2-(carb-oxylato-methyl-sulfan-yl)nicotinato]dicobalt(II)] 1.3-hydrate].

The title complex, [Co2(C8H5NO4S)2(C10H8N2)3(H2O)2]·1.3H2O, was synthesized under hydro-thermal conditions. The Co(II) ion is six-coordinated in a slightly distorted octa-hedral environment resulting from two carboxyl-ate O atoms of two 2-carb-oxy-methyl-sulfanyl nicotinate (2-CMSN(2-)) anions, one water mol-ecule and three N atoms of three 4,4'-bi-pyridine ligands, with one 4,4'-bi-pyridine ligand situated on a centre of inversion.

Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.

It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (TTX) sensitive sodium channels. Recently, many groups have used models of neurological disorder to explore the mechanism of GBP in neuropathic pain.