Publications by authors named "Ruiqin Gu"
Article Synopsis
- Protein binders are being explored as cost-effective and specific alternatives to traditional antibodies, and a new electrochemical biosensor chip has been developed using lead sulfide quantum dots and a synthetic SARS-CoV-2 receptor.
- This biosensor achieves a wide linear response and high sensitivity for detecting spike proteins, with limits of detection as low as 3.31 pg mL.
- Furthermore, this is the first report of using a computationally designed miniprotein receptor for electrochemical biosensing, allowing for efficient and large-scale production of biochips.
Electrochemical sensors that incorporate immunoassay principles have the ability to monitor dynamic processes of antigen-antibody interactions in real time. In this study, a gold electrode was modified with tin dioxide colloidal quantum wire (SnO QWs) and then coated with the leucine/arginine subtype microcystin (MC-LR) antibody. The active site of SnO QWs that was not bound by MC-LR antibody was then passivated with bovine serum protein (BSA).
View Article and Find Full Text PDF