Publications by authors named "Ruiqin Cheng"
Article Synopsis
- The study focuses on how the sugar metabolite fructose-1,6-bisphosphate (FBP) interacts with proteins and its implications for sugar metabolism in human health and disease.*
-
- Researchers used thermal proteome profiling to show that FBP serves as a phosphate donor, activating the enzyme phosphoglycerate mutase 1 (PGAM1) and influencing glycolysis, which is critical for cell growth.*
-
- Findings reveal a novel role for FBP in cancer biology by promoting histidine phosphorylation of PGAM1, leading to the potential development of inhibitors that could slow cancer cell proliferation by targeting sugar metabolic pathways.*
Article Synopsis
- The intestinal epithelial barrier is crucial in the progression of HIV disease, but its damage in different patient groups is not well understood.
- A study compared intestinal damage and related markers among immunological responders (IRs), immunological non-responders (INRs), and healthy controls.
- It found that both IRs and INRs had persistent intestinal damage, with INRs showing more severe damage, which was linked to higher HIV DNA levels and lower CD4 T cell counts.
