Publications by authors named "Ruiqi Tong"
Triple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer, has a poor prognosis and lacks effective treatment strategies. Here, the study discovered that TNBC shows a decreased expression of epithelial transcription factor ovo-like 2 (OVOL2). The loss of OVOL2 promotes fatty acid oxidation (FAO), providing additional energy and NADPH to sustain stemness characteristics, including sphere-forming capacity and tumor initiation.
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- A new chemical reaction has been created that expands a specific type of ring structure, called 3-silaazetidine, using internal alkynes.
- This reaction is facilitated by a catalyst made from palladium (Pd) that activates the bond between silicon and carbon (Si-C).
- The result of this reaction produces unique bicyclic structures known as 6,5- and 6,6-fused 1,3-azasilines, with the silicon atom positioned strategically at the joining point of the rings.
A nonracemic 3-silyl-3-borylhex-4-enoate reagent has been developed. Its asymmetric crotylboration of aldehydes provides --homoallylic alcohols possessing a trisubstituted vinylsilane in high yields with excellent stereo- and enantioselectivity. Diverse decoration of vinylsilane and ester groups, as well as formation of functionalized THF rings, showcase the potential of the approach in the synthesis of polyketide natural products.
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