Quantitative features of osteo-bioactive Ti surfaces at the atomic/molecular level.

The osteo-bioactive potential of biomaterials can be modulated by altering material properties such as chemical composition, surface topography, and geometry. The correlation between the physicochemical properties of biomaterials and their osteo-bioactivity is highly complex. As a material widely used in bone repair, the structure-activity/dose-effect relationship between titanium (Ti) surface features and osteo-bioactivity remains unclear.

Echinocystic acid inhibits sepsis-associated renal inflammation and apoptosis by targeting protein tyrosine phosphatase 1B.

Thefruits of Gleditsia sinensis Lam. have been utilized to treat inflammatory diseases in China. Echinocystic acid (EA), one pentacyclic triterpenoid isolated from thefruits of G.

Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1.

Background: Dysregulation of vascular homeostasis can induce cardiovascular diseases and increase global mortality rates. Although lineage tracing studies have confirmed the pivotal role of modulated vascular smooth muscle cells (VSMCs) in the progression of pathological vascular remodeling, the underlying mechanisms are still unclear.

Methods: The expression of Tudor-SN was determined in VSMCs of artery stenosis, PDGF-BB-treated VSMCs and atherosclerotic plaque.

Multifunctional Glycopeptide-Based Hydrogel via Dual-Modulation for the Prevention and Repair of Radiation-Induced Skin Injury.

The radiation-induced skin injury (RISI) remains a great challenge for clinical wound management and care after radiotherapy, as patients will suffer from the acute radiation injury and long-term chronic inflammatory damage during the treatment. The excessive ROS in the early acute stage and prolonged inflammatory response in the late healing process always hinder therapeutic efficiency. Herein, we developed an extracellular matrix (ECM)-mimetic multifunctional glycopeptide hydrogel (oCP@As) to promote and accelerate RISI repair via a dual-modulation strategy in different healing stages.

Glucopeptide Superstructure Hydrogel Promotes Surgical Wound Healing Following Neoadjuvant Radiotherapy by Producing NO and Anticellular Senescence.

Neoadjuvant radiotherapy, a preoperative intervention regimen for reducing the stage of primary tumors and surgical margins, has gained increasing attention in the past decade. However, radiation-induced skin damage during neoadjuvant radiotherapy exacerbates surgical injury, remarkably increasing the risk of refractory wounds and compromising the therapeutic effects. Radiation impedes wound healing by increasing the production of reactive oxygen species and inducing cell apoptosis and senescence.

Hierarchical Scaffold with Directional Microchannels Promotes Cell Ingrowth for Bone Regeneration.

Bone regenerative scaffolds with a bionic natural bone hierarchical porous structure provide a suitable microenvironment for cell migration and proliferation. Here, a bionic scaffold (DP-PLGA/HAp) with directional microchannels is prepared by combining 3D printing and directional freezing technology. The 3D printed framework provides structural support for new bone tissue growth, while the directional pore embedded in the scaffolds provides an express lane for cell migration and nutrition transport, facilitating cell growth and differentiation.

Toward the Commercialization of Perovskite Solar Modules.

Perovskite (PVSK) photovoltaic (PV) devices are undergoing rapid development and have reached a certified power conversion efficiency (PCE) of 26.1% at the cell level. Tremendous efforts in material and device engineering have also increased moisture, heat, and light-related stability.

Efficient Osteogenic Activity of PEEK Surfaces Achieved by Femtosecond Laser-Hydroxylation.

Poly(etheretherketone) (PEEK) is regarded as an attractive orthopedic material because of its good biocompatibility and mechanical properties similar to natural bone. The efficient activation methods for the surfaces of PEEK matrix materials have become a hot research topic. In this study, a method using a femtosecond laser (FSL) followed by hydroxylation was developed to achieve efficient bioactivity.

Combination Therapies for Advanced Biliary Tract Cancer.

Biliary tract cancers (BTCs) are a group of malignant neoplasms that have recently increased in incidence and have a poor prognosis. Surgery is the only curative therapy. However, most patients are only indicated for palliative therapy because of advanced-stage disease at diagnosis and rapid progression.

Femtosecond laser optimization of PEEK: efficient bioactivity achieved by synergistic surface chemistry and structures.

Poly-ether-ether-ketone (PEEK) is considered a potential orthopedic material due to the excellent mechanical properties and chemical resistance, but its biological inertness hampers its further clinical application. In this study, advanced femtosecond laser microfabrication technology was utilized to induce the change of the surface characteristics of PEEK to improve its bioactivity. Meanwhile, the mechanism of surface reaction and improved bioactivity was interpreted in detail from the perspective of material science.

Tailorable 3DP Flexible Scaffolds with Porosification of Filaments Facilitate Cell Ingrowth and Biomineralized Deposition.

Facilitating cell ingrowth and biomineralized deposition inside filaments of 3DP scaffolds are an ideal bone repair strategy. Here, 3D printed PLGA/HA scaffolds with hydroxyapatite content of 50% (P5H5) and 70% (P3H7) were prepared by optimizing 3D printing inks, which exhibited good tailorability and foldability to meet clinical maneuverability. The supercritical CO foaming technology further endowed the filaments of P5H5 with a richer interconnected pore structure (P5H5-C).

Equilibrium of Tiered Healthcare Resources during the COVID-19 Pandemic in China: A Case Study of Taiyuan, Shanxi Province.

COVID-19 has caused more than 500 million infections and 6 million deaths. Due to a continuous shortage of medical resources, COVID-19 has raised alarm about medical and health resource allocation in China. A balanced spatial distribution of medical and health resources is a key livelihood issue in promoting the equalization of health services.

Constant polarization generation metasurface for arbitrarily polarized light.

State of polarization (SoP) of light is one of the fundamental characteristics of light and has great significance to optical communication, imaging, quantum optics and medical facilities. The generation and maintenance of polarized light have always been research concerns in polarization optics. Polarization-maintaining fibers are frequently used to transmit polarized light without changing its polarization in optical systems, but the high cost and coupling efficiency problems hinder their usage in large-scale light paths.

Expanding the Immunophenotype Spectrum of SMARCA4-Deficient Non-Small Cell Lung Carcinomas: A Case Series with Neuroendocrine Markers Expression.

In recent years, SMARCA4-deficient nonsmall cell lung cancer (NSCLC) has been recognized as a distinct new subtype of lung cancer, which is characterized by loss of SMARCA4 (Brahma-related gene-1 [BRG1]) protein expression. Only a limited number of SMARCA4-deficient NSCLC case series have been reported, and their clinicopathological features have not yet been fully elucidated. Our main aim was to analyze the clinical history, histology, immunohistochemistry, and molecular pathology of 5 SMARCA4-deficient NSCLC patients with poorly differentiated or undifferentiated histology and neuroendocrine markers expression.

Ultra-light planar meta-absorber with wideband and full-polarization properties.

Absorbers have high potential application values in the military field, such as electronic screening, radar cross-section reduction and invisible cloaking. However, most methods have the defects of narrow bandwidth, low absorptivity, complex three-dimensional structure and fixed polarizations. In this paper, we realize an ultra-broadband and full-polarization planar metamaterial absorber (PMA) with a three-layer composite structure, which exhibits multi-resonant and impedance matching properties by combining the ultra-light foams and indium tin oxide (ITO) films.

Detection of epidermal growth factor receptor mutations in non-small cell lung cancer by immunohistochemistry.

Objectives: To evaluate the sensitivity and specificity of immunohistochemistry (IHC) for detecting common epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) and to estimate the cost-effectiveness of IHC testing.

Methods: A total of 208 NSCLC patients were included in the trial, and the EGFR mutation status in the patients were detected by PCR and IHC. Two mutation-specific antibodies against the most common exon 19 deletion (clone SP111) and exon 21 L858R mutation (clone SP125) were tested by using automated immunostainer.

Broad Learning With Reinforcement Learning Signal Feedback: Theory and Applications.

Broad learning systems (BLSs) have attracted considerable attention due to their powerful ability in efficient discriminative learning. In this article, a modified BLS with reinforcement learning signal feedback (BLRLF) is proposed as an efficient method for improving the performance of standard BLS. The main differences between our research and BLS are as follows.

Ultra-thin and high-efficiency full-space Pancharatnam-Berry metasurface.

Full-space metasurfaces (MSs) attract significant attention in the field of electromagnetic (EM) wave manipulation due to their advantages of functionality integration, spatial integration and wide applications in modern communication systems. However, almost all reported full-space metasurfaces are realized by multilayer dielectric cascaded structures, which not only has the disadvantages of high cost and complex fabrication but also is inconvenient to device integration. Thus, it is of great interest to achieve high-efficiency full-space metasurfaces through simple design and easy fabrication procedures.

Anaplastic thyroid carcinoma combined with sclerosing mucoepidermoid carcinoma with eosinophilia: A case report.

Rationale: Anaplastic thyroid carcinoma (ATC) is a rare highly aggressive thyroid malignancy. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia is also a rare low grade malignant thyroid neoplasm. To date, comorbidity of these 2 tumors in the thyroid gland has not been reported in the English literature.

Overexpression of ODF1 in Gastrointestinal Tract Neuroendocrine Neoplasms: a Novel Potential Immunohistochemical Biomarker for Well-differentiated Neuroendocrine Tumors.

Gastrointestinal tract neuroendocrine neoplasms (NENs) are a group of rare heterogeneous tumors with different prognoses. The 2019 WHO classification of digestive system tumors defines the classification of NENs as neuroendocrine tumors (NETs G1-G3) and neuroendocrine carcinomas (NECs). We investigated outer dense fiber of sperm tails 1 (ODF1) expression in 137 gastrointestinal tract NENs including 53 NETs G1, 29 NETs G2, 3 NETs G3, and 52 NECs.

[Role of tumor necrosis factor-alpha in spinal cord injury of rabbits with decompression sickness].

Objective: To observe the pathological changes in rabbits with spinal cord injury induced by decompression sickness (DCS), and to investigate the role of tumor necrosis factor-alpha (TNF-α) in spinal cord injury induced by DCS.

Methods: Rabbits were randomly divided into normal control group, DCS group, and safe decompression group. The rabbit model of DCS was established.

Oncocytic carcinoma of the salivary gland with thymoma: A case report and review of the literature.

Oncocytic carcinoma (OC) arising in the salivary gland is a very rare tumor with only 32 previously reported cases. In this report, we describe a novel case of oncocytic carcinoma with associated thymoma, which arose in the left parotid gland of a 66-year-old male with a history of a painless left parotid mass for 1 year. Oncocytes are large, polygonal cells that are characterized by marked cellular atypia, frequent mitoses, wide eosinophilic granular cytoplasm, a central nucleus and a prominent nucleolus.

[Changes in levels of TNF-α and GFAP in brain and spinal cord of rabbits with decompression disease].

Objective: To investigate the changes in expression of tumor necrosis factor-alpha (TNF-α) and glial fibrillary acidic protein (GFAP) in rabbits with decompression disease (DCS), and to investigate the functioning mechanism.

Methods: A total of 21 healthy adult rabbits were randomly divided into 3 groups: normal control group, DCS group, and safe relief group, with 7 rabbits in each group. A rabbit DCS model was established by quick decompression.

Wnt5a involved in regulation of the biological behavior of hepatocellular carcinoma.

Objective: Wnt5a has been shown to be involved in cancer progression in a variety of tumor types. Previous experimental studies have indicated that it has been shown to be down-regulated in hepatocellular carcinoma (HCC). The goal of this study was to explore the effect of Wnt5a overexpression in an HCC cell line.