Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.

To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).

Salvia miltiorrhiza adjuvant therapy facilitates cardiac function recovery in patients with myocardial infarction.

Myocardial infarction (MI), a leading cause of global mortality, often leads to heart failure and impaired quality of life. This randomized controlled trial evaluated Salvia miltiorrhiza (SM), a traditional Chinese herb containing bioactive compounds like tanshinone IIA and salvianolic acid A, as an adjunct therapy for acute MI. SM is known for anti-inflammatory, antioxidant, anticoagulant and microcirculatory benefits.

Analysis of the effectiveness of aspirin in preventing preeclampsia in high-risk pregnant women and the influencing factors of preeclampsia.

This study explores the effect of aspirin on preeclampsia (PE) and analyzes the influencing factors of PE in high-risk pregnant women. We encompassed 110 high-risk pregnant women receiving prenatal examination at Maternal and Child Health Hospital of Yichang City between January 2022 and December 2023, categorized them into the intervention group (n=58,received aspirin therapy), and the control group (n=52, didn't receive pharmaceutical prophylaxis). Clinical and laboratory parameters were compared between groups, with logistic regression performed.

Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water.

A novel molecularly imprinted polymer (MIP) against gatifloxacin based on a hybrid monomer (3-triethoxysilylpropyl methacrylic amide, APTES-MAA) was reported. In this study, the imprinted monolith was synthesized with gatifloxacin as template, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and APTES-MAA as functional monomer in a mixture of acetonitrile and isooctane as porogen via an optimization based on density functional theory (DFT). The polymers were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and mercury porosimetry.

The DnaJ1 heat shock protein interacts with the flavanone 3-hydroxylase-like protein F3HL to synergistically enhance drought tolerance by scavenging reactive oxygen species in tomato.

The widely distributed heat shock protein DnaJ is renowned for its pivotal role in enhancing thermal tolerance in plants; however, its involvement in drought tolerance remains elusive. In this study, genes encoding DnaJ1 were cloned from drought-resistant wild tomato (Solanum pennellii) and drought-sensitive cultivated tomato (Solanum lycopersicum). SpDnaJ1 and SlDnaJ1 from both tomato species were localized in the chloroplast, and their gene expression was induced by various abiotic stresses.

Right Atrial Function and Right Ventricular Diastolic Function and Their Relation With Exercise Capacity in OSAS.

Background: Right ventricular (RV) diastolic function and right atrial (RA) function are poorly characterized in patients with obstructive sleep apnea syndrome (OSAS), but may influence exercise capacity. We aimed to evaluate RA function and RV diastolic function in OSAS and study their relationship with exercise capacity.

Methods: Fifty-three patients with OSAS and thirty age- and gender-matched controls prospectively underwent echocardiography and cardiopulmonary exercise testing to investigate RV diastolic function, RA function, and exercise capacity.

Integration of Circulating Tumor DNA and Metabolic Parameters on F-Fludeoxyglucose Positron Emission Tomography for Outcome Prediction in Unresectable Locally Advanced Non-Small Cell Lung Cancer.

This prospective study explores the prognostic value of circulating tumor DNA (ctDNA) and positron emission tomography/computed tomograpy (PET/CT) in unresectable locally advanced non-small cell lung cancer (LA-NSCLC) treated with definitive chemoradiotherapy (CRT). The discovery set includes 62 patients, with 62 baseline and 53 post-CRT plasma samples. PET/CT is performed at baseline, and 33 patients undergo mid-treatment scans after 40 Gy.

Gram-Scale Preparation of Tri-Coordinated Single-Atom Catalysts for CO Electrolysis in Large-Scale Membrane Electrode Assembly.

Accelerating the commercialization of CO electroreduction is essential for carbon utilization, yet it faces challenges of precious metal catalysts cost and scaling-up of the corresponding devices. In this study, a low-cost and tri-coordinated single-atom catalyst (SAC) with Ni-N3 center is fabricated in gram-scale using metal ionic liquids as precursor. The gram-scale Ni-N3 SAC (g-NiN3) achieves efficient electroreduction of CO to CO (eCO-to-CO) with a maximum Faradaic efficiency of 98.

Selective Sorting of Semiconducting C@Single-Walled Carbon Nanotube Heterostructures with Narrow Diameter Distribution.

Consistently arranging molecules within single-walled carbon nanotube (SWCNT) templates shows promise for creating advanced 1D heterostructures, but diameter variations in raw SWCNTs pose a significant challenge. In this work, a precise synthesis of C fullerene-filled SWCNTs (C@SWCNTs) is achieved through vapor-phase filling followed by polymer sorting. As the SWCNT diameter increases, C molecules first stack in a single chain, then form unusual configurations, including staggered double chains and double helices-configurations not observed in bulk C crystals.

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.

Myocardial ischemia/reperfusion (I/R) injury is a major contributor to myocardial damage, leading to adverse cardiac remodeling and dysfunction. Recent studies have highlighted the potential of gut microbiota-derived metabolites in modulating cardiac outcomes. Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii (F.

Antagonist Targeting the Species-Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti-H. pylori Infection.

Helicobacter pylori (H. pylori) is a group-1 definite pathogenic carcinogen that infects approximately half of the global population, yet no species-specific chemotherapy has yet been developed. It is previously discovered that H.

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.

Previous studies have established a possible link between hyperhomocysteinemia (HHcy) and dyslipidemia. Circular RNAs (circRNAs) play important regulatory roles in the development of atherosclerosis. However, the biological functions and potential molecular mechanisms of circRNAs in HHcy-induced lipid accumulation leading to atherosclerosis are still unclear.

Biomineralization-Inspired Membranization Toward Structural Enhancement of Coacervate Community.

The design and assembly of protocell models that can mimic the features and functions of life present a significant research challenge with the potential for far-reaching impact. Inspired by the natural phenomenon of microbe-induced mineralization, a way is developed to induce the spontaneous formation of mineralized membrane on the surface of coacervate droplets utilizing Fe ions. In particular, the effect of Fe ions on the microstructure of droplets at the molecular level is dissected by combining theoretical and experimental approaches.

Replicating PET Hydrolytic Activity by Positioning Active Sites with Smaller Synthetic Protein Scaffolds.

Evolutionary constraints significantly limit the diversity of naturally occurring enzymes, thereby reducing the sequence repertoire available for enzyme discovery and engineering. Recent breakthroughs in protein structure prediction and de novo design, powered by artificial intelligence, now enable to create enzymes with desired functions without solely relying on traditional genome mining. Here, a computational strategy is demonstrated for creating new-to-nature polyethylene terephthalate hydrolases (PET hydrolases) by leveraging the known catalytic mechanisms and implementing multiple deep learning algorithms and molecular computations.

The ABF4-bHLH28-COMT5 module regulates melatonin synthesis and root development for drought tolerance in citrus.

Melatonin significantly influences the regulation of plant growth, development, and stress tolerance. However, the regulatory mechanisms underlying melatonin accumulation for drought tolerance in citrus are not fully understood. In this study, we first demonstrated that application of exogenous melatonin resulted in better drought tolerance by reducing water loss and maintaining redox homeostasis.

Formation of an outer glassy shell hinders the drying of trehalose droplets.

Background: Airflow drying of mammalian cells has not been successful yet, with one obstacle being the improper drying time of cells-laden trehalose droplets.

Objective: To evaluate the major factors affecting the drying kinetics of aqueous trehalose droplets.

Materials And Methods: A numerical analysis was applied to the evaporation behavior of aqueous trehalose droplets for the preservation of biomaterials.

Cloning, expression, purification and enzymatic characterization of low-temperature cholesterol esterase from marine Panthenia agglutinosa.

Background: The low-temperature cholesterol esterase is primarily used in industries such as papermaking and healthcare.

Objective: To discover a microorganism with high cholesterol esterase activity and tolerance to low temperatures, leading to the promotion of the sustainable utilization of marine cold-adapted microbial resources and fostering industrial development.

Materials And Methods: This study isolated a strain producing low-temperature cholesterol esterase from marine samples in the China Bohai Sea.

Natural variation and CRISPR/Cas9 gene editing demonstrate the potential for a group VII ethylene response factor HvERF62 in regulating barley (Hordeum vulgare L.) waterlogging tolerance.

Waterlogging stress is a serious problem all over the world, which inhibits plant growth and development, and even leads to plant death in severe circumstances. Ethylene-responsive VII transcription factor (ERFVII) is a key factor regulating plant waterlogging tolerance. In this study, a major QTL conferring chlorophyll content under waterlogging stress was detected on chromosome 4H through GWAS using a natural population.

CPA4 overexpression correlates with poor prognosis and tumor progression in endometrial cancer.

Background: The rise in endometrial cancer rates globally calls for advanced diagnostic methods and new biomarkers. CPA4, known for its role in cancer development, has not yet been studied in relation to endometrial cancer, making it a promising research avenue.

Methods: We analyzed CPA4's mRNA expression using data from TCGA and GEO databases and validated these findings with 116 clinical samples through immunohistochemical analysis.

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model.

The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in the literature. Numerous studies have demonstrated that the activation of the epidermal growth factor receptor 4 (ErbB4) is crucial in neuronal injury and regeneration processes. This study investigated the role of targeted activation of ErbB4 receptor through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), in mitigating PS-MPs-induced neuronal injury.

CT-Based radiomics nomogram of lung and mediastinal features to identify cardiovascular disease in chronic obstructive pulmonary disease: a multicenter study.

Rationale And Objectives: To investigate the performance of two diagnostic models based on CT-derived lung and mediastinum radiomics nomograms for identifying cardiovascular disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD) patients.

Materials And Methods: Hospitalized participants with COPD were retrospectively recruited between September 2015 and April 2023. Clinical data and visual coronary artery calcium score (CACS) were collected.

NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC). However, patients inevitably develop acquired drug resistance, resulting in recurrence or metastasis. It is important to identify novel effective therapeutic targets to reverse acquired TKI resistance.

PLZF-expressing CD4 T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling.

Background: Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4 tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of asthma. Furthermore, promyelocytic leukemia zinc finger (PLZF) is an essential transcription factor involved in asthmatic tolerance and has been implicated in the regulation of CD4CD44 memory T cells.

cfDNA hydroxymethylcytosine profiling for detection metastasis and recurrence of Esophageal Squamous Cell Carcinoma.

Background: A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC.

Methods: The 5hmC-Seal technique was employed to generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) of 122 ESCC patients, classified into 72 with metastasis, 50 without metastasis, 30 with recurrence, and 92 without recurrence.