Generation of the broadband indistinguishable two-photon state in the telecom band.

The indistinguishable photon-pair sources are valuable in many quantum information applications, such as quantum microscopy, quantum synchronization, and quantum metrology. Based on cascaded sum-frequency generation (SFG) and spontaneous parametric downconversion (SPDC) processes, we propose and demonstrate a scheme for the generation of spatially separated broadband indistinguishable photon pairs in the telecom band by using only one piece of a fiber-pigtailed periodically poled lithium niobate waveguide in a modified Sagnac loop. The measured joint spectral intensity of the generated entangled photon pairs is 7.

A motor bearing fault diagnosis model based on multi-adversarial domain adaptation.

In response to the weakened capability of feature transfer and parameter distribution alignment across domains due to significant differences in data distribution collected by different devices, this paper constructs a motor bearing fault diagnosis model based on multi-adversarial domain adaptation. Initially, an improved residual network is employed as the feature extraction module to enhance feature extraction capabilities. It then incorporates a Selective Kernel Network (SKNet) to implement attention mechanisms on convolutional kernels, and a Global Context Network (GCNet) to effectively utilize global contextual information for re-weighting across different channels.

A health index-based approach for fuel cell lifetime estimation.

Efficient health indicators (HI) and prediction methods are crucial for assessing the remaining useful life (RUL) of fuel cells. However, obtaining HI under dynamic conditions with frequently changing loads is highly challenging. Therefore, this study proposes a prediction framework based on dynamic conditions.

Flexible self-standing amidoxime-functionalized MXene membrane for electrochemical uranium extraction.

The presence of radioactive U(VI) ions in sewage poses a significant threat to both the ecological environment and human health. In recent years, an electricity-driven remediation strategy has emerged as aprominent technique for the elimination of radionuclides. Specifically, the square wave transformation method is an emerging technology for electrochemical separation and enrichment of uranium.

Identification and detection of the V1848I indoxacarb resistance mutation in the beet armyworm, Spodoptera exigua.

Indoxacarb is a pivotal insecticide used worldwide to manage Spodoptera exigua, a devastating agricultural pest. This active compound plays a crucial role in resistance management strategies due to its distinctive mode of action. A field population of S.

Metabolome profiling and transcriptome analysis unveiling the crucial role of magnesium transport system for magnesium homeostasis in tea plants.

Magnesium (Mg) is a crucial nutrient for the growth and development of and is closely related to the quality of tea. However, the underlying mechanisms responding to low-Mg stress in tea plants remain largely unknown. In this study, photosynthetic parameters, metabolomics, and transcriptomics were utilized to explore the potential effects of low Mg on the growth and metabolism of .

MoRgs3 functions in intracellular reactive oxygen species perception-integrated cAMP signaling to promote appressorium formation in .

Unlabelled: Regulator of G-protein signaling (RGS) proteins exhibit GTPase-accelerating protein activities to govern G-protein function. In the rice blast fungus , there is a family of at least eight RGS and RGS-like proteins (MoRgs1 to MoRgs8), each exhibiting distinct or shared functions in the growth, appressorium formation, and pathogenicity. MoRgs3 recently emerged as one of the crucial regulators that senses intracellular oxidation during appressorium formation.

Selective degradation of hyperphosphorylated tau by proteolysis-targeting chimeras ameliorates cognitive function in Alzheimer's disease model mice.

Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases. Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic damage in AD. Proteolysis-targeting chimeras (PROTACs) are a novel type of chimeric molecule that can degrade target proteins by inducing their polyubiquitination.

Research on S-type fiber Bragg grating acceleration sensor for low-frequency vibration monitoring.

The acquisition of low-frequency vibration signals in earthquake exploration is a crucial aspect of seismic exploration technology. Addressing the difficulty current fiber optic sensors face in monitoring low-frequency vibrations, this paper proposes an acceleration sensor based on S-type Fiber Bragg Grating (FBG). First, an FBG acceleration sensor model is established and theoretically analyzed.

Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.

Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). However, extensive phase II metabolism and poor aqueous solubility led to a decrease in the chrysin concentration in the blood after oral administration, limiting its pharmacological development . In the present study, we synthesized a novel chrysin derivative prodrug (C-1) to address this issue.

Computational study on the endocrine-disrupting metabolic activation of Benzophenone-3 catalyzed by cytochrome P450 1A1: A QM/MM approach.

Predicting the metabolic activation mechanism and potential hazardous metabolites of environmental endocrine-disruptors is a challenging and significant task in risk assessment. Here the metabolic activation mechanism of benzophenone-3 catalyzed by P450 1A1 was investigated by using Molecular Dynamics, Quantum Mechanics/Molecular Mechanics and Density Functional Theory approaches. Two elementary reactions involved in the metabolic activation of BP-3 with P450 1A1: electrophilic addition and hydrogen abstraction reactions were both discussed.

Potassium-Hydrogen Hybrid Ion Alkaline Battery: A New Rechargeable Aqueous Battery Combined a K Storage Cathode and an Electrochemical Hydrogen Storage Anode.

A rechargeable aqueous hybrid ion alkaline battery, using a proton and a potassium ion as charge carriers for the anode and cathode, respectively, is proposed in this study by using well-developed potassium nickel hexacyanoferrate as the cathode material and mesoporous carbon sheets as the anode material, respectively. The constructed battery operates in a concentrated KOH solution, in which the energy storage mechanism for potassium nickel hexacyanoferrate involves the redox reaction of Fe/Fe associated with potassium ion insertion/extraction and the redox reaction of Ni(OH)/NiOOH. The mechanism for the carbon anode is electrochemical hydrogen storage.

Phenazine biosynthesis protein MoPhzF regulates appressorium formation and host infection through canonical metabolic and noncanonical signaling function in Magnaporthe oryzae.

Microbe-produced secondary metabolite phenazine-1-carboxylic acid (PCA) facilitates pathogen virulence and defense mechanisms against competitors. Magnaporthe oryzae, a causal agent of the devastating rice blast disease, needs to compete with other phyllosphere microbes and overcome host immunity for successful colonization and infection. However, whether M.

The knockout of the nicotinic acetylcholine receptor subunit gene α1 (nAChR α1) through CRISPR/Cas9 technology exposes its involvement in the resistance of Spodoptera exigua to insecticides.

Insect nicotinic acetylcholine receptors (nAChRs) are the directed targets of many insecticides. However, there have been no reports on the molecular characterization of the nAChR gene family or the causal association between nAChR α1 and resistance to insecticides in S. exigua, which is a significant agricultural pest.

Anti-cervical cancer mechanism of bioactive compounds from based on the 'compound-target-disease' network.

In this study, we analyzed the chemical compositions of (Sieb. et Zucc.) Harms (AP) using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) non-targeted plant metabolomics integration MolNetEnhancer strategy.

Miniaturized fiber Bragg grating accelerator sensors for low-frequency vibration monitoring.

Acceleration monitoring is an important technical means of seismic monitoring, oil exploration, deep well observation, etc. A miniaturized fiber Bragg grating (FBG) acceleration sensor with three cantilever beams is proposed against the fact that it is difficult for fiber-optic sensors to meet the requirements for low-frequency vibration monitoring. First, the model of the FBG acceleration sensor was built and theoretically analyzed; second, the effect of structural parameters on sensor sensitivity and natural frequency was analyzed, and the sensors were subjected to static stress analysis and modal simulation analysis through the ANSYS finite element analysis software; finally, the real sensors were developed and subjected to performance tests with a low-frequency vibration test system.

MicroRNA-989 targets 5-hydroxytryptamine receptor1 to regulate ovarian development and eggs production in Culex pipiens pallens.

Background: Female mosquitoes need a blood meal after mating for their eggs to develop, and this behavior leads to the spread of pathogens. Therefore, understanding the molecular regulation of reproduction in female mosquitoes is essential to control mosquito vector populations. In this study, we reported that microRNA-989 (miR-989), which targets 5-HTR1 (encoding secreted 5-hydroxytryptamine receptor1), is essential for mosquito reproduction.

Discrete frequency-bin entanglement generation via cascaded second-order nonlinear processes in Sagnac interferometer.

Discrete frequency-bin entanglement is an essential resource for applications in quantum information processing. In this Letter, we propose and demonstrate a scheme to generate discrete frequency-bin entanglement with a single piece of periodically poled lithium niobate waveguide in a modified Sagnac interferometer. Correlated two-photon states in both directions of the Sagnac interferometer are generated through cascaded second-order optical nonlinear processes.

GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer.

Background: Glucosamine 6-phosphate N-acetyltransferase (GNPNAT1) is a crucial enzyme involving hexosamine biosynthesis pathway and is upregulated in breast cancer (BRCA). However, its biological function and mechanism on patients in BRCA have not been investigated.

Methods: In this study, the differential expression of GNPNAT1 was analyzed between BRCA tissues and normal breast tissues using the Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database, which was validated by quantitative real-time polymerase chain reaction, Western blot and immunohistochemistry.

Hertz-rate metropolitan quantum teleportation.

Quantum teleportation can transfer an unknown quantum state between distant quantum nodes, which holds great promise in enabling large-scale quantum networks. To advance the full potential of quantum teleportation, quantum states must be faithfully transferred at a high rate over long distance. Despite recent impressive advances, a high-rate quantum teleportation system across metropolitan fiber networks is extremely desired.

Gender-specific data-driven adiposity subtypes using deep-learning-based abdominal CT segmentation.

Objective: The aim of this study was to quantify abdominal adiposity and generate data-driven adiposity subtypes with different diabetes risks.

Methods: A total of 3817 participants from the Pinggu Metabolic Disease Study were recruited. A deep-learning-based recognition model on abdominal computed tomography (CT) images (A-CT model) was developed and validated in 100 randomly selected cases.

Mechanistic insights into Cr(VI) removal by a combination of zero-valent iron and pyrite.

Recent studies have revealed that a combination of zero-valent iron (ZVI) and pyrite (FeS) can effectively remove (Cr(VI)) from water, but the reasons behind this synergistic effect are still unclear. Our batch experiments showed that dissolved oxygen (DO) is a critical factor in the improved removal of Cr(VI) by ZVI and pyrite. When 0.