Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies.

Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement activation in DKD is of particular interest. In this study, the glomerular proteome, especially the profiles of the complement proteins, was analyzed in kidney biopsies from 40 DKD patients and 10 normal controls using laser microdissection-assisted liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS).

Clinicopathological characteristics of light chain proximal tubulopathy: a multicentre case series.

Aims: Light chain proximal tubulopathy (LCPT) is a rare complication of paraprotein-related diseases. We report a case series to present the clinicopathological characteristics and outcomes of LCPT.

Methods: A multicentre retrospective case series of 47 patients with LCPT, consisting of 36 crystalline, three non-crystalline, and eight mixed LCPTs, was studied between January 2007 and December 2023.

Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation.

Increased proinflammatory cytokines and infiltration of inflammatory cells in the stroma are important pathological features of type IIIA chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS-A), and the interaction between stromal cells and other cells in the inflammatory microenvironment is closely related to the inflammatory process of CP/CPPS-A. However, the interaction between stromal and epithelial cells remains unclear. In this study, inflammatory prostate epithelial cells (PECs) released miR-203a-3p-rich exosomes and facilitated prostate stromal cells (PSCs) inflammation by upregulating MCP-1 expression.

Clinicopathological characteristics and prognosis in patients with monoclonal gammopathy and renal damage in central China: a multicenter retrospective cohort study.

Renal involvement is common in monoclonal gammopathy (MG); however, the same patient may have both MG and non-paraprotein-associated renal damage. Accordingly, distinguishing the cause of renal damage is necessary because of the different clinical characteristics and associated treatments. In this multicenter retrospective cohort study, we described the clinicopathological characteristics and prognosis of 703 patients with MG and renal damage in central China.

Nanotherapeutics for prostate cancer treatment: A comprehensive review.

Prostate cancer (PCa) is the most prevalent solid organ malignancy and seriously affects male health. The adverse effects of prostate cancer therapeutics can cause secondary damage to patients. Nanotherapeutics, which have special targeting abilities and controlled therapeutic release profiles, may serve as alternative agents for PCa treatment.

Beyond the individual: An improved telecom fraud detection approach based on latent synergy graph learning.

The development of telecom technology not only facilitates social interactions but also inevitably provides the breeding ground for telecom fraud crimes. However, telecom fraud detection is a challenging task as fraudsters tend to commit co-fraud and disguise themselves within the mass of benign ones. Previous approaches work by unearthing differences in calling sequential patterns between independent fraudsters, but they may ignore synergic fraud patterns and oversimplify fraudulent behaviors.

Novel mutations in in Chinese patients with Wilson's disease and identification of kidney disorder of thinning of the glomerular basement membrane.

Introduction: Wilson's disease is an autosomal recessive disorder caused by pathogenic mutations. The hallmark of this disorder mainly consists of liver involvement, neurologic dysfunction and psychiatric features. In addition, the kidneys can also be affected by excessive copper deposition.

Prognostic prediction by F-FDG-PET/CT parameters in patients with neuroblastoma: a systematic review and meta-analysis.

Purpose: Neuroblastoma is a solid malignant tumor with high malignancy and high risk for metastasis. The prognosis of neuroblastoma ranges from spontaneous regression to insensitivity to therapies and widespread metastasis. There is a non-invasive, panoramic imaging technique called F-fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT), which can provide both complete anatomical information CT and extent of FDG uptake value in tumors positron emission detection.

CycMuNet+: Cycle-Projected Mutual Learning for Spatial-Temporal Video Super-Resolution.

Spatial-Temporal Video Super-Resolution (ST-VSR) aims to generate high-quality videos with higher resolution (HR) and higher frame rate (HFR). Quite intuitively, pioneering two-stage based methods complete ST-VSR by directly combining two sub-tasks: Spatial Video Super-Resolution (S-VSR) and Temporal Video Super-Resolution (T-VSR) but ignore the reciprocal relations among them. 1) T-VSR to S-VSR: temporal correlations help accurate spatial detail representation; 2) S-VSR to T-VSR: abundant spatial information contributes to the refinement of temporal prediction.

Glucocorticoid nanoformulations relieve chronic pelvic pain syndrome and may alleviate depression in mice.

Background: Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is no effective treatment for CPPS due to its recurrence and intractability. For synergistic CPPS therapy, we developed pH/reactive oxygen species (ROS) dual-responsive dexamethasone (Dex) nanoformulations using a ROS-responsive moiety and phytochemical modified α-cyclodextrin (α-CD) as the carrier.

Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics.

Background: Early diagnosis and typing are crucial for improving the prognosis of patients with renal amyloidosis. Currently, Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. Although untargeted proteomics achieve ultra-high-throughput by selecting the most abundant eluting cationic peptide precursors in series for tandem MS events, it lacks in sensitivity and reproducibility, which may not be suitable for early-stage renal amyloidosis with minor damages.

Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma.

Osteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO@PA NPs) for osteosarcoma treatment.

Established the first clinical prediction model regarding the risk of hyperuricemia in adult IgA nephropathy.

Objective: To construct a novel nomogram model that predicts the risk of hyperuricemia incidence in IgA nephropathy (IgAN).

Methods: Demographic and clinicopathological characteristics of 1184 IgAN patients in the First Affiliated Hospital of Zhengzhou University Hospital were collected. Univariate analysis and multivariate logistic regression were used to screen out hyperuricemia risk factors.

targeting capacities of different nanoparticles to prostate tissues based on a mouse model of chronic bacterial prostatitis.

Chronic bacterial prostatitis usually occurs in men and seriously affects the quality of life of patients. The efficacy of chronic bacterial prostatitis treatment is limited by the difficulty for free drugs (e.g.

Application of Artificial Neural Network Algorithm in Facial Biological Image Information Scanning and Recognition.

In order to solve the problem that the accuracy of face recognition is not good due to the influence of jitter and environmental factors in the mobile shooting environment, this paper proposes the application of an artificial neural network algorithm in the information scanning and recognition of face biological images. The spatial neighborhood information is integrated into the amplitude detection of multipose face images, and the dynamic corner features of multipose face images are extracted. The structural texture information of multipose face images is compared to a global moving RGB three-dimensional bit plane random field, and the multipose face images are detected and fused.

COVID-19 contact tracking by group activity trajectory recovery over camera networks.

Contact tracking plays an important role in the epidemiological investigation of COVID-19, which can effectively reduce the spread of the epidemic. As an excellent alternative method for contact tracking, mobile phone location-based methods are widely used for locating and tracking contacts. However, current inaccurate positioning algorithms that are widely used in contact tracking lead to the inaccurate follow-up of contacts.

Mechanisms of Senescence-Related NKG2D Ligands Release and Immune Escape Induced by Chemotherapy in Neuroblastoma Cells.

Chemotherapy-induced senescence promotes immunocyte aggregation in the tumor microenvironment by upregulating the surface expression of activating ligands in cancer cells. However, these senescent tumor cells cannot be completely cleared and can induce tumor recurrence. Previous studiesshowed that soluble natural killer (NK) group 2D (NKG2D) ligands impair the recognition of multiple immune cells.

Antibiotic-loaded reactive oxygen species-responsive nanomedicine for effective management of chronic bacterial prostatitis.

Chronic bacterial prostatitis (CBP) occurs frequently in the male population and significantly influences quality of life. Antibiotics are the main strategy for managing chronic bacterial prostatitis; however, most antibiotics have low efficacy due to their poor penetration of prostate tissues. To overcome this challenge, we fabricated cefpodoxime proxetil (CPD)-loaded reactive oxygen species (ROS)-responsive nanoparticles (NPs) for targeted treatment of CBP.

Hyperuricemia aggravates the progression of IgA nephropathy.

Objective: The relationship between hyperuricemia and IgA nephropathy (IgAN) was evaluated systematically in this research.

Methods: The Preferred Reporting Items for Systematic Review and Meta-analysis statement was employed to design and report the study.

Results: Twenty-five studies were included in this meta-analysis with a total of 6048 IgAN patients.

MicroRNA-137 targets EZH2 to exert suppressive functions in uveal melanoma via regulation of Wnt/β-catenin signaling and epithelial-to-mesenchymal transition.

Purpose: Uveal melanoma (UM) is one of the primary intraocular malignancies. Emerging studies have confirmed dysregulation of microRNA (miRNA/miR) in UM. The present study focused on the biofunctions of miR-137 in UM.

Association between thrombotic microangiopathy and activated alternative complement pathway in malignant nephrosclerosis.

Background: Malignant nephrosclerosis, defined as renal microangiopathy in the setting of severe hypertension, remains a critical renal emergency leading to end-stage renal disease despite aggressive anti-hypertensive treatment. Recently, activation of the complement alternative pathway (AP) has been reported to play a prominent role in the pathogenesis of malignant nephrosclerosis. However, subsequent study failed to recapitulate the findings of genetic complement abnormalities in the disease.

Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases.

Chronic kidney diseases have become a major issue worldwide. The spectrum of biopsy proven renal diseases differs between locations and changes over time. It is therefore essential to describe the local epidemiological trends and the prevalence of renal biopsy in various regions to shine new light on the pathogenesis of various renal diseases and provide a basis for further hypothesis-driven research.

Ultrasound assisted surface micro-dissolution to embed nano TiO on cotton fabrics in ZnCl aqueous solution.

In this paper, a simple and environment friendly approach was used to prepare the multifunctional composite fabrics via coating commercial TiO nanoparticles (NPs) on the surface of cotton fibers by surface micro-dissolution process in 55%wt ZnCl aqueous solution under the aid of ultrasound without any adhesive. The TiO/cotton composite fabrics were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and thermal gravity (TG) methods. The treated fabric had photocatalytic property in Rhodamine B (RhB) degradation, and had good antibacterial activity against Escherichia coli (E.

Ensemble Super-Resolution With a Reference Dataset.

By developing sophisticated image priors or designing deep(er) architectures, a variety of image super-resolution (SR) approaches have been proposed recently and achieved very promising performance. A natural question that arises is whether these methods can be reformulated into a unifying framework and whether this framework assists in SR reconstruction? In this paper, we present a simple but effective single image SR method based on ensemble learning, which can produce a better performance than that could be obtained from any of SR methods to be ensembled (or called component super-resolvers). Based on the assumption that better component super-resolver should have larger ensemble weight when performing SR reconstruction, we present a maximum a posteriori (MAP) estimation framework for the inference of optimal ensemble weights.