Aggregation-induced emission (AIE) of Au(I)-GSH complexes activated by cationic polymer for sensitive foodborne pathogens detection and inactivation.

Aggregation-induced emission (AIE) is a novel signal output method but is limited in pathogen sensing. Herein, a multifunctional biosensor based on the AIE properties of Au(I)-GSH complexes as signal conversion tags was firstly constructed for rapid and sensitive total bacteria. Bacteria were captured by the boronic acid group of MNPs@Au@4-MPBA (MAu@MPBA) through recognition of peptidoglycan on their surface.

A programmable sensitive platform for pathogen detection based on CRISPR/Cas12a -hybridization chain reaction-poly T-Cu.

Rapid and sensitive detection of pathogenic bacteria is crucial for disease prevention and control. The CRISPR/Cas12a system with the DNA cleavage capability holds promise in pathogenic bacteria diagnosis. However, the sensitivity of CRISPR-based assays remains a challenge.

Effect of doramectin on programmed cell death pathway in glioma cells.

Purpose: Doramectin (DRM) is a kind of avermectin drugs, and it has been shown that DRM has anti-cancer effects. However, the molecular mechanism of DRM in programmed cell death (PCD) aspects is still unclear. The objective of this study was to confirm whether DRM induced PCD in glioma cells.

Colorimetric sensing of glucose and GSH using core-shell Cu/Au nanoparticles with peroxidase mimicking activity.

The catalytic properties of bimetallic nanoparticles have been widely studied by researchers in many fields. In this paper, core-shell Cu/Au nanoparticles (Cu/Au NPs) were synthesized by a simple and mild one-pot method, and their peroxidase activity was proved by catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) with color change to blue. The change of solution color and absorbance strongly depends on the concentration of HO, so it can be used for direct detection of HO and indirect detection of glucose.

Cu modified Zr-based metal organic framework-CTAB-graphene for sensitive electrochemical detection of sunset yellow.

A sensitive electrochemical sensor for sunset yellow (SY) was constructed based on cetyltrimethylammonium bromide (CTAB) functionalized graphene (Gr) and Cu/Zr-MOF electrode modified materials. The CTAB-Gr-Cu/Zr-MOF composites were synthesized by using a mild method and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and EDX spectrum. The combination of Cu/Zr-MOF and graphene exhibited synergetic effect of the strong accumulation efficiency, fast electron transfer rate and more sensing sites towards the oxidation of SY.

Polyoxometalates-graphene nanocomposites modified electrode for electro-sensing detection of Sudan I in food.

Sudan I, a lipophilic azo dye -dye, is desirable and urgent to be accurate detected due to its increasing levels and high toxicity in food and environmental monitoring and analysis. Herein, a sensitive electrochemical sensor for Sudan I was established based on a new KPWFe(HO)O functionalized carbon nanomaterials (FePW-GNPS). The electrode modified nanocomposite, FePW-GNPS, was successfully fabricated and characterized by FTIR, SEM and UV-vis.

Recent Advances in Polyoxometalates with Enzyme-like Characteristics for Analytical Applications.

Artificial enzymes based on inorganic solids with both enzyme-mimetic activities and the special material features has been a promising candidate to overcome many deleterious effects of native enzymes in analytical applications. Polyoxometalates (POMs) are an importance class of molecular metal-oxygen anionic clusters. Their outstanding physicochemical properties, versatility and potential applications in energy conversion, magnetism, catalysis, molecular electronics and biomedicine have long been studied.

A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing.

Wound healing greatly affects patients' health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant (MRSA), drain excessive biofluid to promote wound healing, and simultaneously monitor wound pH level. The polyoxometalate (α-KPWO·14HO, PW) and oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) nanofiber to synergistically inhibit MRSA.

Multienzymatic Antioxidant Activity of Manganese-Based Nanoparticles for Protection against Oxidative Cell Damage.

Oxidative stress is related to many diseases, but available clinical treatment methods are currently limited. Exploitation of enzyme-mimicking nanomaterials (nanozymes) is a promising way for scavenging reactive oxygen species (ROS) and treatment of ROS-related diseases. Herein, the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GP) mimicking activities are expressed by MnO nanoparticles (MnOBSA NPs) coated with BSA.

A GdW@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy.

Anticancer treatment is largely affected by the hypoxic tumor microenvironment (TME), which causes the resistance of the tumor to radiotherapy. Combining radiosensitizer compounds and O self-enriched moieties is an emerging strategy in hypoxic-tumor treatments. Herein, we engineered GdW@PDA-CAT (KNaHGdWO·2HO, GdW, polydopamine, PDA, catalase, CAT) composites as a radiosensitizer for the TME-manipulated enhancement of radiotherapy.

Vancomycin recognition and induced-aggregation of the Au nanoparticles through freeze-thaw for foodborne pathogen Staphylococcus aureus detection.

Infectious diseases caused by foodborne pathogens have become a serious public health problem. It is urgent to develop simple, rapid, and visual methods for pathogen detection. Herein, gold nanoparticles (AuNPs), aptamer and vancomycin (Van) based dual-recognition molecules and magnetic enrichment were combined to realize visual detection of Staphylococcus aureus (S.

In Vitro Antifungal Activity and Mechanism of AgPWO Composites against Species.

Fungal infections pose a serious threat to human health. Polyoxometalates (POMs) are metal-oxygen clusters with potential application in the control of microbial infections. Herein, the AgPWO composites have been synthesized and verified by Fourier transform infrared (FT-IR) spectrum, transmission electron microscopy (TEM), scanning electron microscope (SEM), elemental analysis, and X-ray diffraction (XRD).

Anisotropic active ligandations in siRNA-Loaded hybrid nanodiscs lead to distinct carcinostatic outcomes by regulating nano-bio interactions.

Active targeting modification is one of the foremost nanomedicine strategies for the efficacy improvement. Compared to the homogeneous ligandation on spherical nanocarriers, non-spherical nanomedicines usually make the ligand modification more complicated. The modified ligands always exhibit anisotropy and heterogeneity.