Publications by authors named "Ruimei Jiang"
Article Synopsis
- IL-10-producing B cells (B10 cells) are important for suppressing autoimmune responses and reducing inflammation, but their exact role in type 1 diabetes is not well understood.
- In a study using NOD mice, it was found that B10 cells increased in number during the development of diabetes, especially in the pancreas-draining lymph nodes, but their ability to regulate T cell responses was diminished.
- The findings suggest that a decrease in both the quantity and function of B10 cells might contribute to the onset and progression of type 1 diabetes.
Recently, pancreatic islet transplantation has been shown to be a viable option for the treatment of type 1 diabetes mellitus. However, immune destruction becomes the major impediment to the clinical application of islet transplantation. Here, we evaluated changes affecting multiple types of immune cells and cytokines in allogeneic islet transplantation immunity after the administration of B10 cells alone and explored the regulatory mechanisms of B10 cells in T cell-mediated allograft rejection.
View Article and Find Full Text PDFIslet autotransplantation (IAT) is a viable treatment for patients with severe chronic pancreatitis, this modality may prevent brittle diabetes mellitus after pancreatectomy. This systematic review and meta-analysis was performed to evaluated the outcomes of IAT after TP and discuss the factors that may affect the efficacy of this procedure. MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1977 to 30 April 2014.
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