Comparison of Different Types of Poly-L-Lactic Acid Microspheres In Vitro and In Vivo Studies.

Background: Biodegradable polymers are commonly used as dermal fillers in plastic surgery. Among these, poly-L-lactic acid (PLLA) distinguishes itself owing to its good biocompatibility, degradability, and ability to act as a collagen stimulator.

Objectives: In this study, the differential behavior of PLLA microspheres with varying microscopic morphology and surface hydrophilicity was investigated both in vitro and in vivo.

Identification of new antigenic epitopes of porcine reproductive and respiratory syndrome virus nsp12 protein using monoclonal antibodies.

Porcine reproductive and respiratory syndrome virus (PRRSV), a member of the arteritis virus family, significantly impacts the swine industry due to its high infectiousness. nsp12, the nonstructural protein encoded by PRRSV, is a membrane-associated protein, with limited knowledge about its antigenic properties and functions. In this study, we used the expressed and purified nsp12 protein as antigen to immunize mice, and successfully screened five positive hybridoma cell lines that stably secrete anti-nsp12 monoclonal antibodies using immunological assays such as indirect ELISA and IFA.

Study of two-dimensional information writing, reading and error correction at micro/nanoscale based on gold nanosphere arrays.

Surface plasmon driven photocatalytic reactions have great potential for information encryption as well as information security. In this paper, explored the detection concentrations of dye molecule Rhodamine6G (R6G) on three substrates, where complete original Raman spectra signals were still obtained at a concentration of 10 M. Utilized photosensitive molecules to investigate the photocatalytic characteristics of 4-nitrobenzenethiol (4-NBT) on three substrates.

AgCNER, the First Large-Scale Chinese Named Entity Recognition Dataset for Agricultural Diseases and Pests.

Named entity recognition is a fundamental subtask for knowledge graph construction and question-answering in the agricultural diseases and pests field. Although several works have been done, the scarcity of the Chinese annotated dataset has restricted the development of agricultural diseases and pests named entity recognition(ADP-NER). To address the issues, a large-scale corpus for the Chinese ADP-NER task named AgCNER was first annotated.

A Novel Approach to Surface Roughness Virtual Sample Generation to Address the Small Sample Size Problem in Ultra-Precision Machining.

Surface roughness is one of the main bases for measuring the surface quality of machined parts. A large amount of training data can effectively improve model prediction accuracy. However, obtaining a large and complete surface roughness sample dataset during the ultra-precision machining process is a challenging task.

Spatially confined CuFeO nanosphere in N/O-codoped porous carbon mimetics for triple-mode sensing of antibiotics and visual detection of neurotransmitters in biofluids.

Background: Carbon-based nanozymes have recently received enormous concern, however, there is still a huge challenge for inexpensive and large-scale synthesis of magnetic carbon-based "Two-in-One" mimics with both peroxidase (POD)-like and laccase-like activities, especially their potential applications in multi-mode sensing of antibiotics and neurotransmitters in biofluids. Although some progresses have been made in this field, the feasibility of biomass-derived carbon materials with both POD-like and laccase-like activities by polyatomic doping strategy is still unclear. In addition, multi-mode sensing platform can provide a more reliable result because of the self-validation, self-correction and mutual agreement.

In Situ Loading of NiZnC Nanoparticles with Carbon Nanotubes to 3D Melamine Sponge Derived Hollow Carbon Skeleton toward Superior Microwave Absorption and Thermal Resistance.

The simple and low-cost construction of a 3D network structure is an ideal way to prepare high-performance electromagnetic wave (EMW) absorption materials. Herein, a series of carbon skeleton/carbon nanotubes/NiZnC composites (CS/CNTs/NiZnC) are successfully prepared by in situ growth of NiZnC and CNTs on 3D melamine sponge carbon. With the increase of precursor, NiZnC nanoparticles nucleate and catalyze the generation of CNTs on the surface of the carbon skeleton.

Biotemplated fabrication of N/O co-doped porous carbon confined spinel NiFeO heterostructured mimetics for triple-mode sensing of antioxidants and ameliorating packaging properties.

In this work, shrimp shell-derived magnetic NiFeO/N, O co-doped porous carbon nanozyme with superior oxidase (OXD)-like activity was prepared and used for colorimetric/photothermal/smartphone dual-signal triple-mode detection of antioxidants in fruits and beverages. The magnetic NiFeO/N, O co-doped porous carbon (MNPC) material was triumphantly fabricated using a combined in-situ surface chelation and pyrolysis method. The resultant MNPC composite exhibits a superior OXD-like activity, which can effectively oxidize 3,3',5,5'-tetramethylbenzidine (TMB) for yielding colorimetric/temperature dual-signal (CTDS) in absence of HO.

Education counteracts the genetic risk of Alzheimer's disease without an interaction effect.

Background: Alzheimer's disease (AD) is a major cause of disability and mortality in older adults. This study aimed to investigate the association of AD with education and genetic factors.

Methods: We conducted a prospective cohort study using data from the UK Biobank.

Summary of Turbocharging as a Waste Heat Recovery System for a Variable Altitude Internal Combustion Engine.

The increase in altitude causes the decrease in internal combustion engine power and the increase in pollutant emission. Converting waste heat into more useful forms of energy through the recovery of waste heat from internal combustion engines is the most promising mechanism for improving both of these goals. This paper comprehensively reviews the development and research of waste heat recovery technology of an internal combustion engine in a variable altitude environment.

Influence of InP/ZnS Quantum Dots on Thermodynamic Properties and Morphology of the DPPC/DPPG Monolayers at Different Temperatures.

In this work, the effects of InP/ZnS quantum dots modified with amino or carboxyl group on the characteristic parameters in phase behavior, elastic modulus, relaxation time of the DPPC/DPPG mixed monolayers are studied by the Langmuir technology at the temperature of 37, 40 and 45 °C. Additionally, the information on the morphology and height of monolayers are obtained by the Langmuir-Bloggett technique and atomic force microscope technique. The results suggest that the modification of the groups can reduce the compressibility of monolayers at a higher temperature, and the most significant effect is the role of the amino group.

Spatiotemporal Evolution and Driving Forces of PM in Urban Agglomerations in China.

With the rapid development of China's economy, the process of industrialization and urbanization is accelerating, and environmental pollution is becoming more and more serious. The urban agglomerations (UAs) are the fastest growing economy and are also areas with serious air pollution. Based on the monthly mean PM concentration data of 20 UAs in China from 2015 to 2019, the spatiotemporal distribution characteristics of PM were analyzed in UAs.

Gene therapy targeting miR‑212‑3p exerts therapeutic effects on MAFLD similar to those of exercise.

Exercise is the main treatment for patients with metabolic‑associated fatty liver disease (MAFLD); however, it may be difficult for some patients to adhere to or tolerate an exercise regime. Thus, finding a treatment alternative to exercise is of particular importance. The authors have previously demonstrated that the high expression of microRNA (miRNA/miR)‑212 promotes lipogenesis .

Digital Quantum Simulation and Circuit Learning for the Generation of Coherent States.

Coherent states, known as displaced vacuum states, play an important role in quantum information processing, quantum machine learning, and quantum optics. In this article, two ways to digitally prepare coherent states in quantum circuits are introduced. First, we construct the displacement operator by decomposing it into Pauli matrices via ladder operators, i.

The effects of aerobic exercise on body composition in overweight and obese patients with gout: a randomized, open-labeled, controlled trial.

Background: Overweight and obesity are typical risk factors for the increased prevalence and incidence of gout. The existing guidelines unequivocally indicated that exercise is highly advantageous for patients with gout. Nevertheless, there is still a lack of specific guidance and clinical evidence.

[Comparison of wall filter algorithms for ultrasonic microvascular imaging].

The design of wall filter in ultrasonic microvascular imaging directly affects the resolution of blood flow imaging. We compared the traditional polynomial regression wall filter algorithm and two algorithms based on singular value decomposition (SVD), Full-SVD algorithm and RS-RSVD algorithm (random sampling based on random singular value decomposition) through experiments with simulated data and human renal entity data imaging experiments. The experimental results showed that the filtering effect of the traditional polynomial regression wall filter algorithm was limited, however, Full-SVD algorithm and RS-RSVD algorithm could better extract the micro blood flow signal from the tissue or noise signal.

Porcine epidemic diarrhea virus strain FJzz1 infection induces type I/III IFNs production through RLRs and TLRs-mediated signaling.

Interferons (IFNs) including type I/III IFNs are the major components of the host innate immune response against porcine epidemic diarrhea virus (PEDV) infection, and several viral proteins have been identified to antagonize type I/III IFNs productions through diverse strategies. However, the modulation of PEDV infection upon the activation of the host's innate immune response has not been fully characterized. In this study, we observed that various IFN-stimulated genes (ISGs) were upregulated significantly in a time- and dose-dependent manner in LLC-PK1 cells infected with the PEDV G2 strain FJzz1.

Tetrandrine-induced downregulation of lncRNA NEAT1 inhibits rheumatoid arthritis progression through the STAT3/miR-17-5p pathway.

Background: The inhibitory effect of Tetrandrine (Tet) on rheumatoid arthritis (RA) is well established. However, its exact molecular mechanism remains unknown.

Methods: RT-qPCR coupled with western blotting was employed to analyze the expression of NEAT1, miR-17-5p, and STAT3 in RA tissues and/or RA-fibroblast-like synoviocytes (RA-FLS) treated with 3 μmol/L of Tet for 48 h.

Whole-Exome Sequencing Identifies a Novel Variant (c.1538T > C) of in Arrhythmogenic Right Ventricular Cardiomyopathy.

Backgrounds: Arrhythmic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy with a genetic predisposition that can lead to a sudden cardiac death and heart failure. According to the 2010 Task Force Criteria, genetic diagnosis is one of the most important methods, but, so far, only a few genes related to ARVC have been identified.

Methods: In this study, the pathogenic gene of a patient with ARVC was examined using whole-exome sequencing.