Publications by authors named "Ruilan Ma"
Members from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog. However, relative to RAS subfamily members KRAS, NRAS, and HRAS, our characterization of RIT1 oncogenic properties remains incomplete.
View Article and Find Full Text PDFOvarian cancer is a frequently observed type of gynaecologic malignancy generally associated with poor prognosis around the world. Ubiquitin-specific proteases (USPs) form the largest subfamily of deubiquitylating enzymes and have emerged as potential therapeutic targets against human cancers. Through a systematic analysis of the prognostic significance of USP expression, USP2 was found to be inversely correlated with patient survival in ovarian cancer.
View Article and Find Full Text PDFArticle Synopsis
- Human papillomaviruses (HPVs) are prevalent sexually transmitted viruses that can lead to genital warts and cancers, with China being a major contributor to global HPV cases and deaths.
- The study analyzed HPV genome sequences from China, identifying common types like HPV-16 and notable novel strains, and categorized them into alpha- and gamma-papillomaviruses.
- A phylogeographic analysis revealed genetic similarities and the presence of recombination events among HPV types, providing insights that could inform effective HPV prevention strategies in China and beyond.
Background: Osteosarcoma (OS) is the most prevalent orthopedic malignancy with a dismal prognosis. Disulfidptosis-related lncRNAs (DRLncs) may be related to the progression of OS, but their potential molecular regulatory role is still unclear.
Methods: Based on the data collected from The Cancer Genome Atlas (TCGA), we conducted correlation analysis and the univariate Cox analysis to screen prognosis-related DRLncs, followed by developing genotyping patterns and corresponding classifier.
Article Synopsis
- - The study compared the effects of immediate implant-based breast reconstruction (IBBR) on radiation therapy for breast cancer patients who had modified radical mastectomy, analyzing dosimetry, complications, and quality of life.
- - Results showed that patients in the IBBR group had different dosimetric outcomes, such as higher planning target volume (PTV) but lower doses to critical organs like the heart and lung, with no significant difference in complications like radiation pneumonia or dermatitis.
- - Additionally, patients who underwent IBBR reported higher quality of life scores 6 months post-radiotherapy compared to those who did not have reconstruction, suggesting that IBBR may be beneficial in radiation therapy contexts.
Dinaciclib is a selective cyclin-dependent kinase inhibitor, but its radiosensitizing effect remains unclear. The aim of this study is to investigate the radiosensitizing effect of Dinaciclib on cervical cancer cells. Two cervical cancer cell lines, Hela and Siha, were selected, and the IC50 was determined by CCK8.
View Article and Find Full Text PDFAt present, the mechanism for clopidogrel resistance (CR) is incompletely understood. Here, we aimed to analyze of the association of plasma concentration of clopidogrel active metabolites (CAM) and CYP2C19 genetic polymorphism with CR. We assigned 77 patients to receive CLP at a loading dose of 300mg on day 1, followed by 75mg per day from day 2 to day 6.
View Article and Find Full Text PDFObjective: To evaluate the outcomes and prognostic factors of distant metastasis in patients with advanced cervical squamous cell carcinoma treated with concurrent chemoradiotherapy (CCRT).
Methods: A total of 118 patients with International Federation of Gynecology and Obstetrics (FIGO, 2009 version) stage II b-IVa cervical squamous cell carcinoma treated with CCRT between 2006 and 2010 in the Second Affiliated Hospital of Dalian Medical University were analyzed. Their median age was 48 years (range, 23-70 years).
Flavopiridol is a cyclin-dependent kinase inhibitor. It has shown an antitumor effect against several cancers. In the present study, the radiation-sensitizing effect of flavopiridol was investigated in an esophageal squamous carcinoma cell line, Eca109.
View Article and Find Full Text PDF[Present situation of congenital defects in five counties (cities) of Gansu province in 2009 - 2010].
Zhonghua Liu Xing Bing Xue Za Zhi
February 2013
Objective: To understand the situation of congenital defects' in five counties/cities in Gansu province so as to provide scientific evidence for the development of effective interventions.
Methods: General information was collected on all the neonates who were born in Dunhuang city, Jingchuan county, Hui county, Weiyuan county and Yongjing county in Gansu province between Oct. 1(st), 2009 to Sep.