Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.

Objective: Human immunodeficiency virus (HIV)-infected individuals who abuse methamphetamine (METH) exhibit more severe neurotoxicity and cognitive impairment. Pyroptosis, a programmed cell death pathway mediated by the inflammasome, has been implicated in various neurological diseases. This study aimed to elucidate the role of the AIM2 inflammasome in METH- and HIV-1 Tat-induced pyroptosis in human brain tissue and in vitro models.

America and the special relationship: the impact of the Trump administration on relations with the UK.

The article seeks to assess to what extent the Trump presidency damaged the Anglo-American special relationship. By drawing on a theoretical framework that is broader than much of the existing literature, this article argues that the Trump presidency inflicted largely short-term damage on the special relationship. Though common interests, common sentiments and mutual utility between the US and the UK were weakened in the Trump era, the institutionalized underpinnings of the special relationship were sufficiently robust to withstand the corrosive effects of the 'Trump doctrine'.