Quaternity method for integrated screening, separation, extraction optimization, and bioactivity evaluation of acetylcholinesterase inhibitors from Sophora flavescens Aiton.

Introduction: Sophora flavescens Aiton (Fabaceae), a ubiquitous plant species in Asia, contains a wide range of pharmacologically active compounds, such as flavonoids, with potential anti-Alzheimer's disease (anti-AD) effects.

Objectives: The objective of the study is to develop a quaternity method for the screening, isolation, extraction optimization, and activity evaluation of acetylcholinesterase (AChE)-inhibiting compounds from S. flavescens to realize high-throughput screening of active substances in traditional Chinese medicine and to provide experimental data for the development of anti-AD drugs.

Catalytic conversion of carbohydrates into 5-ethoxymethylfurfural using γ-AlOOH and CeO@BO catalyst synergistic effect.

Selective catalytic conversion of carbohydrates to 5-ethoxymethylfurfural (EMF) is a critical approach to the biorefinery. In this work, solid acid catalysts of γ-AlOOH and CeO@BO were used to convert carbohydrates to EMF in a one-pot process, performed in an ethanol/DMSO solvent system. The synergistic effect of γ-AlOOH and CeO@BO was studied.

Sulfonic acid-functionalized PCP(Cr) catalysts with Cr and -SOH sites for 5-ethoxymethylfurfural production from glucose.

5-Ethoxymethylfurfural (EMF) has been identified as a potential biofuel and fuel additive, for which the production from glucose (the most abundant and inexpensive monosaccharide) in a one-step process would be highly desirable. Here, the synthesis of sulfonic acid-functionalized porous coordination polymers (PCPs) and their application as catalysts for EMF synthesis are reported. PCP(Cr)-BA (PCP material with Cr ions and HBDC-SOH linkers) and PCP(Cr)-NA (PCP material with Cr ions and HNDC(SOH) linkers) materials containing both Cr sites and Brønsted-acidic -SOH sites were prepared.

Adsorption of copper(II) and lead(II) from seawater using hydrothermal biochar derived from Enteromorpha.

The objective of this research was to evaluate the capacity of Enteromorpha derived biochar to adsorb heavy metals from seawater. The biochar characteristics were determined, and isothermal and kinetic data were obtained using batch experiments. Copper [Cu(II)] and lead [Pb(II)] adsorption by the biochar was favored by high pH conditions, while elevated salinity had a relatively weak negative effect on adsorption.

Transformation of corncob into furfural by a bifunctional solid acid catalyst.

A transformation route was developed for the conversion of raw corncob into furfural by a Clbearing solid acid catalyst (HSCSOH) prepared by the hydrothermal carbonization and sulfonation of sucralose. The catalytic performances of HSCSOH in selected solvents were demonstrated and optimized, where a furfural yield of 90.8 mol% (20.

Distribution, bioaccumulation and trophic transfer of chlorinated polyfluoroalkyl ether sulfonic acids in the marine food web of Bohai, China.

Chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) caused great concerns recently as novel fluorinated alternatives. However, information on their bioconcentration, bioaccumulation and biomagnification in marine ecosystems is limited. In this study, 152 biological samples including invertebrates, fishes, seabirds and mammals collected from Bohai Sea of China were analyzed to investigate the residual level, spatial distribution, bioaccumulation and biomagnification of Cl-PFESAs.

Occurrence and seasonal variations of per- and polyfluoroalkyl substances (PFASs) including fluorinated alternatives in rivers, drain outlets and the receiving Bohai Sea of China.

A simultaneous sampling campaign was undertaken to study the pollution by 21 per- and polyfluoroalkyl substances (PFASs) in rivers, drain outlets and their receiving Bohai Sea of China. Chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) are being used as fluorinated alternatives and they were included in this study. In comparison with other regions and countries, high concentrations of ∑PFASs in seawater samples from the Bohai Sea, ranging from 5.

Occurrence and inputs of perfluoroalkyl substances (PFASs) from rivers and drain outlets to the Bohai Sea, China.

Concentrations of 19 PFASs in riverwater, coastal wastewater and effluents from WWTPs which were directly discharged into the Bohai Sea of China were measured and their inputs to this sea area were calculated accordingly. For riverwater samples, the total PFAS concentrations ranged from 13.1 to 69 238 ng/L.

Occurrence, spatial and temporal distributions of perfluoroalkyl substances in wastewater, seawater and sediment from Bohai Sea, China.

In this study, surface seawater and sediment samples were collected from Bohai Sea, China, to investigate the temporal and spatial distributions of perfluoroalkyl substances (PFASs) in that area. The total concentrations of PFASs in seawater and sediment samples ranged from below method limit of quantification ( View Article and Find Full Text PDF

Levels and spatial distribution of perfluoroalkyl substances in China Liaodong Bay basin with concentrated fluorine industry parks.

Eighteen different perfluoroalkyl substances (PFASs) were investigated in 35 river water samples and 34 sediment samples collected from rivers in the Liaodong Bay basin containing two fluorine industry parks. Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were the predominant PFASs in freshwater, with median concentrations of 26.5 ng/L and 1.

[Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].

Objective: To screen the differentially expressing genes between silicotic lung tissue and normal lung tissue, to identify the differentially expressing genes of matrix metalloproteinase-12 (MMP-12) and Cathepsin E and to explore the roles of those genes in silicosis development.

Methods: Thirty male SD rats were divided randomly into two groups: control group (6 rats) and exposure group (24 rats) which was exposed to SiO2 by intra-tracheal perfusion. On the 30 th, 60 th and 90 th days after exposure, 8 rats in model group and 2 rats in control group were executed and the lung tissues were obtained.

[Expression of vascular endothelial growth factor and microvessel density in rabbit radius defects repaired with allogeneic and autogenic bone].

Objective: To investigate the expression levels and significance of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in rabbit radius defects repaired with allogeneic and autogenic bone.

Methods: Forty adult New Zealand rabbits were chosen, and 10 mm bone defect model was created in the bilateral radii of 28 experimental rabbits. The other 12 rabbits provided allogeneic bone under the standard of American Association of Tissue Bank.

[Experimental study on adhesiveness of osteoblasts and vascular endothelial cells from rat BMSCs co-cultured on allogeneic freeze-dried partially bone in vitro].

Objective: To investigate the adhesiveness of osteoblasts and vascular endothelial cells from rat BMSCs.

Methods: The BMSCs were isolated from 4-week-old SD co-cultured on allogeneic freeze-dried partially bone in vitro. rats (weighing 100-110 g) and cultured in vitro.