The Impact of Plan Complexity on Dose Delivery Deviations Resulting from MLC Positioning Errors in Volumetric Modulated Arc Therapy.

Objectives: To assess the effect of plan complexity on dosimetric alterations induced by multi-leaf collimator (MLC) misplacements in volumetric modulated arc therapy (VMAT).

Methods: VMAT plans for 14 cervical and 10 lung cancer cases were reoptimized utilizing three distinct Aperture Shape Controller settings (none, very high, very low), resulting in three plan groups: ASC-none, ASC-vh, and ASC-vl. Four types of MLC position errors were simulated: total shifts (Type 1), open/closed (Type 2), right-side shifts (Type 3), and left-side shifts (Type 4).

1064 nm InGaAs metamorphic laser power converts with over 44% efficiency.

InGaAs metamorphic laser power converters (LPCs) have the potential to deliver electrical energy over distances of several kilometers. In this study, metalorganic chemical vapor deposition (MOCVD) was used to grow InGaAs-based LPCs with an absorption wavelength of 1064 nm. At step thicknesses of 2800 nm, overshoot thicknesses of 6000 nm, reverse component and thicknesses of 2.

High-performance laser power converts for direct-energy applications.

Six-junction GaAs laser power converts (LPCs) were designed and fabricated. Each subcell is vertically connected by p++-AlGaAs: C/n++-AlGaAs: Si: Te (1:2) tunnel junction with good thermal stability and a record peak tunneling current density of 1867 A/cm. The I-V characteristics of LPCs with an aperture of 10×10 mm were investigated as a function of laser power and temperature.

An updated network meta-analysis of EGFR-TKIs and combination therapy in the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer.

Objectives: Tyrosine kinase inhibitors (TKIs) are a standard care option in patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation. TKI-based combination treatment modes show encouraging outcomes. However, it remains unknown which is the optimal treatment as the first-line regimen for these patients on overall survival (OS).

Validation and testing of a novel pencil-beam model derived from Monte Carlo simulations in carbon-ion treatment planning for different scenarios.

Purpose: The calculation ability of the newly-proposed accurate beam model, the double Gaussian-logistic (DG-L) model, was validated in both homogeneous and heterogeneous phantoms to provide helpful information for its future application in clinical carbon-ion treatment planning system (TPS).

Methods: MatRad was used as the new algorithm test platform. Based on Monte Carlo (MC) method, the basic database in matRad was generated, then comparative dosimetric analyses between the single Gaussian (SG), double Gaussian (DG) and DG-L models against the MC recalculations were performed on the treatment plans of a cubic water phantom, a TG119 phantom and a liver patient scenario.