Scleral Contact Lens Benefits for Myopic Patients With Regular Corneas: A Prospective Randomized Study.

Objectives: To evaluate the impact of scleral contact lens (SL) wear on the visual quality and the ocular surface wettability in myopic patients with regular corneas.

Methods: This prospective, randomized, controlled study enrolled a total of 80 myopes with regular corneas. Subjects were randomly allocated to wear SL or rigid corneal lens (RCL) for 3 months.

Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires.

Purpose: This prospective study aimed to validate the translated Chinese versions of the Ocular Surface Disease Index (OSDI), 5-Item Dry Eye (DEQ-5), and Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) questionnaires and test their repeatability.

Methods: From August 2022 to July 2023, online (qualtrics.com) English and Chinese versions of OSDI, DEQ-5, and CLDEQ-8 questionnaires were distributed to residents of Hong Kong, mainland China, Taiwan, and Singapore ≥ 18 years old who could understand both written Chinese and English.

Kirigami Design Smart Contact Lens for Highly Sensitive Eyelid Pressure Measurement.

Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures.

Effects and Related Factors of Short-time Accommodation Training on Measuring Consistency of InnovEyes Sitemap, Autorefraction, and Subjective Refraction.

Purpose: To evaluate effects and related factors of short-time accommodation training on measuring consistency of InnovEyes Sitemap (Alcon/WaveLight; Alcon Laboratories, Inc), NIDEK ARK-1 autorefractor (Nidek Corporation), and subjective refraction (SR).

Methods: One hundred adults (100 eyes) with myopia aged 17 to 40 years were enrolled. Refraction was obtained by InnovEyes Sitemap, autorefraction, and SR in a randomized order.

Causal association between glaucoma and risk of retinal vascular occlusion: a Mendelian randomization study.

Objective: Retinal vein occlusion (RVO) leads to visual impairment, and risk factors may include glaucoma. Although some studies suggest a relationship between glaucoma and RVO, it is unknown whether this association is causal. We performed Mendelian randomization (MR) analyses to evaluate the causal contribution to RVO of five genetically predicted glaucoma conditions.

Unveiling the Mysteries of the Chinese lens zonule balance tension: A statistical analysis.

Background: This study aims to provide an estimated dataset of lens zonule balance tension (LZBT) measurements in cataractous lenses among Chinese patients and to conduct a statistical analysis of anterior segment parameters.

Methods: This is a cross-sectional study. We included a total of 833 eyes from 833 Chinese participants aged 23-91 years who underwent cataract surgery.

Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.

Background: To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.

Methods: This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis.

Comparison of therapeutic effects of 0.05% Cyclosporine A versus 0.1% Fluorometholone in Chinese patients with mild dry eye unresponsive to artificial tears: a randomized control study.

Background: To assess and compare the therapeutic outcomes of 0.05% Cyclosporine A (CsA) ophthalmic solution versus 0.1% Fluorometholone (FML) eyedrops in Chinese patients with mild dry eye disease (DED) unresponsive to conventional artificial tears (AT).

Impact of Astigmatism on Axial Elongation in School-Age Children: A Five-Year Population-Based Study in Tianjin, China.

Purpose: To investigate the progression rates of axial length (AXL) among school-age children with baseline astigmatism and spherical ametropia.

Methods: Annual vision screenings were conducted at seven schools in Tianjin, China, from 2018 to 2022. Ocular biometry and non-cycloplegic autorefraction were collected.

IMPACTS OF POSTERIOR STAPHYLOMA ON PARAPAPILLARY MICROVASCULATURE AND ATROPHY IN HIGH MYOPIC EYES: A Matched Cohort Study With Optical Coherence Tomography Angiography.

Purpose: To evaluate the impacts of the different types of posterior staphyloma (PS) in high myopia on parapapillary microvasculature and parapapillary atrophy (PPA, i.e., γ-zone and δ-zone) with optical coherence tomography angiography.

Association of serum 25-hydroxyvitamin D concentrations and myopia in the U.S. Population - Results from the NHANES 2001-2008.

Background: myopia is associated with sight-threatening potential complications, and it becoming increasingly common globally. However, the association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and myopia remains unclear and the evidence is controversial. Thus, this study aimed to investigate the association between serum 25(OH)D concentrations and myopia in the U.

Changes in anterior segment after short-term scleral lens wear in healthy Chinese population.

Purpose: To evaluate the impact of short-term scleral lens (SL) wear on anterior chamber (AC) dimension and central corneal thickness (CCT) in healthy Chinese people.

Methods: This is a prospective, daily wear study. Eligible participants were dispensed SLs to correct refractive errors.

Socioeconomic disparities and green space associated with myopia among Chinese school-aged students: A population-based cohort study.

Background: There is increasing evidence on the link between environmental factors and myopia in children and adolescents, yet with inconsistent conclusions. We investigated the associations between socioeconomic inequalities and green space with myopia in school-aged students participating in the Tianjin Child and Adolescent Research of Eye (TCARE) study.

Methods: We obtained data from a population-based dynamic cohort study conducted in Tianjin, China, in 2021 and followed up in 2022.

Ocular biometric characteristics of Han ethnicity in Tianjin and Uyghur ethnicity in Xinjiang undergoing cataract surgery.

Aim: To analyze and compare the differences among ocular biometric parameters in Han and Uyghur populations undergoing cataract surgery.

Methods: In this hospital-based prospective study, 410 patients undergoing cataract surgery (226 Han patients in Tianjin and 184 Uyghur patients in Xinjiang) were enrolled. The differences in axial length (AL), anterior chamber depth (ACD), keratometry [steep K (Ks) and flat K (Kf)], and corneal astigmatism (CA) measured using IOL Master 700 were compared between Han and Uyghur patients.

The Myopia Prevalence and Association With Physical Activity Among Primary School Students Aged 6-12 Years: A Cross-Sectional Study in Tianjin, China.

Purpose: This study aimed to investigate the prevalence of myopia and determine the association between physical activity and risk of myopia among primary school students in Tianjin, China.

Methods: A cross-sectional study was conducted among subjects from nine primary schools. All of the subjects underwent visual acuity and spherical equivalent (SE) with noncycloplegic autorefraction measurement.

AS101 regulates the Teff/Treg balance to alleviate rabbit autoimmune dacryoadenitis through modulating NFATc2.

Sjögren's syndrome (SS) dry eye can cause ocular surface inflammation and lacrimal gland (LG) damage, leading to discomfort and potential vision problems. The existing treatment options for SS dry eye are currently constrained. We investigated the possible therapeutic effect and the underlying mechanism of AS101 in autoimmune dry eye.

Myopia Control Effect of Repeated Low-Level Red-Light Therapy Combined with Orthokeratology: A Multicenter Randomized Controlled Trial.

Purpose: To investigate the efficacy and safety of repeated low-level red-light (RLRL) therapy combined with orthokeratology among children who, despite undergoing orthokeratology, exhibited an axial elongation of at least 0.50 mm over 1 year.

Design: Multicenter, randomized, parallel-group, single-blind clinical trial (ClinicaTrials.

Evaluating the microcirculation of the dome-shaped macula and its complications in adults with highly myopic eyes by swept-source optical coherence tomography angiography.

Purpose: The aim of this study was to investigate the microcirculatory characteristics of the dome-shaped macula (DSM), its complications in highly myopic eyes and to explore the factors associated with a DSM.

Methods: This cross-sectional case-control study included a total of 98 subjects (98 eyes): 49 eyes with DSM and 49 eyes without DSM. The axial length (AL) of the myopic eyes was matched 1:1 to eliminate the effect of AL differences on the results.

INOS ablation promotes corneal wound healing via activation of Akt signaling.

Corneal injury leads to impaired normal structure of the cornea. Improving the wound healing process in epithelial cells significantly contributes to ocular damage treatments. Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), in the process of corneal wound healing.

Dimethyl itaconate inhibits antigen-specific Th17 cell responses and autoimmune inflammation via modulating NRF2/STAT3 signaling.

Pathogenic Th17 cells play a crucial role in autoimmune diseases like uveitis and its animal model, experimental autoimmune uveitis (EAU). Dimethyl itaconate (DMI) possesses potent anti-inflammatory effects. However, there is still a lack of knowledge about the role of DMI in regulating pathogenic Th17 cells and EAU.