Evolution of dissolved organic nitrogen (DON) during sludge reject water treatment revealed by FTICR-MS.

This study evaluated the ability to remove dissolved organic matter (DOM), particularly dissolved organic nitrogen (DON), at a molecular level using Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) in a full-scale reject water treatment project comprising three steps of short-cut nitrification and denitrification, two-stage AO, and ultrafiltration membrane system. The results indicated that short-cut nitrification and denitrification were effective in reducing the DON concentration from an average of about 180 mg/L to 43 mg/L. The average molecular weight of DOM showed a decreasing trend from 238 Da to 160 Da.

Enhanced sludge settlement of two stage PN/Anammox for reject water treatment with respective diatomite addition.

The present study investigated the potential of diatomite addition in enhancing sludge settlement of two-stage PN/Anammox for real reject water treatment, with a focus on sludge settling velocity, nitrogen removal capacity, sludge morphological features, and microbial community changes. The study found that diatomite addition significantly improved the sludge settleability of the two-stage PN/A process, resulting in a decrease in sludge volume index (SVI) from 70 to 80 mL/g to about 20-30 mL/g for both PN and Anammox sludge, although the sludge-diatomite interaction differed between the two types of sludge. In the PN sludge, diatomite acted as a carrier, while in the Anammox sludge, it acted as micro-nuclei.

AF-SSD: An Accurate and Fast Single Shot Detector for High Spatial Remote Sensing Imagery.

There are a large number of studies on geospatial object detection. However, many existing methods only focus on either accuracy or speed. Methods with both fast speed and high accuracy are of great importance in some scenes, like search and rescue, and military information acquisition.

lncRNA VIM‑AS1 promotes cell proliferation, metastasis and epithelial‑mesenchymal transition by activating the Wnt/β‑catenin pathway in gastric cancer.

The present study aimed to explore the biological functions and molecular mechanisms of the long non‑coding RNA VIM antisense RNA 1 (VIM‑AS1) in gastric cancer (GC). The expression of VIM‑AS1 was analyzed in tissues from patients with GC and GC cell lines by reverse transcription‑quantitative (RT‑q)PCR. The relationship between VIM‑AS1 expression and overall survival time of patients with GC was also assessed.

[Significance of peripheral perfusion index in early diagnosis and goal-directed therapy of septic shock patients: a prospective single-blind randomized controlled trial].

Objective: To investigate the application of peripheral perfusion index (PPI) in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock.

Methods: A prospective single-blind randomized controlled trial (RCT) was conducted. Adult patients with sepsis admitted to emergency medical department and intensive care unit (ICU) of the First People's Hospital of Lianyungang City in Jiangsu Province from January 2013 to December 2016 were enrolled.

Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway.

C-C chemokine receptor type 7 (CCR7) has been implicated in lymph node metastasis of various cancers. Previous studies have revealed that epithelial‑mesenchymal transition (EMT) is involved in the chemotactic process mediated by CCR7 and its ligands in various types of carcinoma. However, the underlying mechanism of this process remains to be fully elucidated.

Efficacy and safety of proprotein convertase subtilisin/kexin type 9 monoclonal antibody in adults with familial hypercholesterolemia.

Proprotein convertase-subtilisin/kexin type 9 (PCSK9) monoclonal antibody is a new therapy to reduce low-density lipoprotein cholesterol (LDL-C) level in patients with familial hypercholesterolemia (FH). This pooled analysis aimed to estimate the efficacy and safety of PCSK9 antibody therapy in FH. Reports of randomized controlled trials (RCTs) comparing PCSK9 antibody to placebo were retrieved by a search of MEDLINE via PubMed, EMBASE, the Cochrane Library databases, ClinicalTrials.

Inhibitory effects of short hairpin RNA against caspase-8 on apoptosis of murine hepatoma Hepa1-6 cells.

Caspase-8 plays an important role in death-receptor-mediated apoptosis of hepatocytes. We constructed short hairpin RNAs (shRNAs) against caspase-8 and investigated the effects of caspase-8 targeting shRNAs on apoptosis of Hepa1-6 cells induced by TNF-alpha. Oligonucleotides coding for four shRNAs against caspase-8 were cloned into mammalian expression vector Pgenesil-1 containing U6 promoter, which were then introduced into Hepa1-6 cells using liposome-mediated transfection.