Basal cell carcinoma with perineural invasion: A prospective study examining subtype, tumor surface diameter, invasion depth, and anatomic site in 3005 consecutive cases.

Background: Basal cell carcinoma (BCC) may present with or without perineural invasion (PNI). We reviewed BCC for PNI by subtype, microscopic tumor surface diameter, invasion depth, and anatomic site.

Method: Consecutive excisions were prospectively collected in an Australian center 2016-2018.

Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases.

Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI).

Objective: To investigate the characteristics of early invasive SCC with or without PNI.

Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018.

Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases.

Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies.

Objective: To investigate BCC invasion depth variation by subtype and anatomic site.

Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic.

Early invasive squamous cell carcinoma recurrence rates: A study examining surgical margins, tumor surface diameter, invasion depth, and grade of differentiation in 1296 cases over 9 years.

Background: Invasive squamous cell carcinoma (SCC) is typically treated by surgical excision.

Methods: Consecutive SCC excisions were reviewed prospectively in a single Australian center from 2009 to 2017. Cases were examined for recurrence by histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation, and anatomic site.

Superficial basal cell carcinoma: A comparison of superficial only subtype with superficial combined with other subtypes by age, sex and anatomic site in 3150 cases.

Background: Basal cell carcinoma (BCC) may present as superficial subtype alone (sBCC) or superficial combined with other subtypes. The objective of this study was to compare sBCC without or with other BCC subtypes by age, sex and anatomic site.

Methods: We retrospectively collected superficial BCC with the above characteristics from an Australian center during 2009 to 2014.

Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats.

Dysfunction of energy metabolism can be a significant and fundamental pathophysiological basis for strokes. In studies of both humans and rodents, resveratrol, a natural polyphenol, has been reported to provide protection from cerebral ischemic injury by regulating expression of silent mating type information regulation 2 homolog 1 (SIRT1). However, direct evidence demonstrating that resveratrol exerts neuroprotection from cerebral ischemia injury by decreasing energy consumption is still lacking.