Publications by authors named "Ruifeng Ray Guo"
Article Synopsis
- Acral fibrochondromyxoid tumor (AFCMT) is a recently identified, likely benign tumor found in the hands and feet, characterized by distinct histological features and a specific genetic fusion (THBS1::ADGRF5).
- In a study of 37 cases, the tumors predominantly affected middle-aged individuals (median age 47) and displayed well-defined structures with vascularity and chondrocyte-like cells in a chondromyxoid environment.
- Immunohistochemical tests showed most tumors positive for CD34 and ERG but negative for S100 protein, indicating that AFCMT is a unique entity distinct from other similar tumors.
Article Synopsis
- - Sweat gland neoplasms are complex and rare skin tumors, making them a tricky area for doctors who study skin diseases (dermatopathology) and recent research has revealed different biological markers for several types of these tumors.
- - A study evaluated various sweat gland tumors in patients, using techniques like immunohistochemistry and RNA sequencing to help identify specific tumor types based on their unique features.
- - Findings showed that specific tests, such as p63 IHC, BRAF V600E IHC, and MAML2 FISH, can effectively assist in accurately diagnosing sweat gland tumors, offering valuable tools for pathologists when the usual assessment is unclear.
Am J Dermatopathol
April 2024
Article Synopsis
- Cutaneous malignant mixed tumor (MMT) is a rare type of tumor originating from sweat glands, noted for having both malignant epithelial cells and a specific stroma, with only about 50 cases reported so far.
- A 70-year-old woman had a mass on her eyebrow that was diagnosed as cutaneous MMT, which later spread to her lungs, confirmed through biopsy.
- This case adds to the limited literature on cutaneous MMT with lung metastasis, highlighting the rarity of such occurrences and aiming to raise awareness among medical professionals.
Pathol Res Pract
January 2024
Article Synopsis
- Primary melanoma of the nipple (PMN) is extremely rare, with only a few documented cases, and this study identified 10 patients diagnosed with it.
- The patients included 5 females and 5 males, with a median age of 55.5 years, and follow-up showed that 9 were disease-free, although 1 patient died due to nodal metastasis.
- An interesting case involved a pigmented lesion that had features of both melanoma in situ and Paget disease, highlighting challenges in accurate diagnosis and the need for awareness of these unusual conditions.
